Kenneth L Jacobs

US Patent:

48824224, Nov 21, 1989

Filed:

Sep 24, 1987

Appl. No.:

7/100372

Inventors:

H. William Taeusch - Redondo Beach CA
Kenneth A. Jacobs - Newton MA
D. Randall Steinbrink - Melrose MA
Joanna Floros - West Roxbury MA
David S. Phelps - West Roxbury MA
Edward F. Fritsch - Concord MA

Assignee:

Genetics Institute, Inc. - Cambridge MA

International Classification:

C07K 1300
A61K 3702

US Classification:

530350

Abstract:

This invention relates to novel proteins useful for enhancing pulmonary surfactant activity, methods for obtaining said proteins and compositions containing one or more of the proteins. The proteins of this invention include the following: 1. A protein characterized by a molecular weight of about 35 kd and by being encoded for by the DNA sequence depicted in Table 1. 2. A protein characterized by a molecular weight of about 35 kd and by being encoded for by the DNA sequence depicted in Table 2. 3. A protein encoded for by a portion of the DNA sequence depicted in Table 6 and characterized by a molecular weight of about 5. 5-9 kd; and 4. A protein characterized by a molecular weight of about 5. 5-9 kd and an amino acid composition as set forth in Table 4.