Kenneth M Kaye

US Patent:

6756203, Jun 29, 2004

Filed:

Jun 28, 2001

Appl. No.:

09/894273

Inventors:

Elliott D. Kieff - Brookline MA 02445
Mary E. Ballestas - Beverly MA
Kenneth M. Kaye - Weston MA

Assignee:

Elliott D. Kieff - Brookline MA

International Classification:

C12Q 168

US Classification:

435 6, 435 691, 435975, 536 2372

Abstract:

Primary effusion lymphoma (PEL) cells harbor Kaposis sarcoma-associated herpesvirus (KSHV) episomes and express a KSHV encoded latency-associated nuclear antigen (LANA). In PEL cells, LANA and KSHV DNA co-localized in dots in interphase nuclei and along mitotic chromosomes. In the absence of KSHV DNA, LANA was diffusely distributed in the nucleus or on mitotic chromosomes. In lymphoblasts, LANA was necessary and sufficient for the persistence of episomes containing a specific KSHV DNA fragment. Furthermore, LANA co-localized with the artificial KSHV DNA episomes in nuclei and along mitotic chromosomes. The KSHV DNA segment that provides for efficient persistence in LANA positive cells has been identified as the rhodino virus cis-acting element (RVCAE). These results support a model in which LANA tethers episomes containing the KSHV RVCAE DNA to chromosomes during mitosis to enable efficient segregation to progeny cells. The products and methods of the invention are useful in identifying compounds for modulating (especially including interfering with) the persistance of rhodino virus DNA in mammalian cells, and disease states associated therewith, as well as such compounds themselves.

US Patent:

63227924, Nov 27, 2001

Filed:

Apr 21, 1999

Appl. No.:

9/298568

Inventors:

Elliott D. Kieff - Brookline MA
Mary E. Ballestas - Beverly MA
Kenneth M. Kaye - Weston MA

International Classification:

A61K 3912
A61K 39245
C17N 1500

US Classification:

4241991

Abstract:

Primary effusion lymphoma (PEL) cells harbor Kaposi's sarcoma-associated herpesvirus (KSHV) episomes and express a KSHV encoded latency-associated nuclear antigen (LANA). In PEL cells, LANA and KSHV DNA co-localized in dots in interphase nuclei and along mitotic chromosomes. In the absence of KSHV DNA, LANA was diffusely distributed in the nucleus or on mitotic chromosomes. In lymphoblasts, LANA was necessary and sufficient for the persistence of episomes containing a specific KSHV DNA fragment. Furthermore, LANA co-localized with the artificial KSHV DNA episomes in nuclei and along mitotic chromosomes. The KSHV DNA segment that provides for efficient persistence in LANA positive cells has been identified as the rhodino virus cis-acting element (RVCAE). These results support a model in which LANA tethers episomes containing the KSHV RVCAE DNA to chromosomes during mitosis to enable efficient segregation to progeny cells. The products and methods of the invention are useful in identifying compounds for modulating (especially including interfering with) the persistance of rhodino virus DNA in mammalian cells, and disease states associated therewith, as well as such compounds themselves.

US Patent:

50167499, May 21, 1991

Filed:

May 29, 1990

Appl. No.:

7/529604

Inventors:

Kenneth Kaye - Cranford NJ
Barbara Kaye - Cranford NJ

International Classification:

B65D 8538

US Classification:

206 51

Abstract:

A device for simultaneously carrying spectacles and contact lenses which includes a hollow open base for containing the spectacles, the base further containing a contact lens case secured to an interior surface thereof for containing a pair of contact lenses. A lid is hingedly connected to the base for covering the opening therein and may support a mirror affixed thereto to assist in installing or removing the contact lenses.