Kenneth Richardson

US Patent:

50632370, Nov 5, 1991

Filed:

May 1, 1990

Appl. No.:

7/517116

Inventors:

Kelvin Cooper - New York NY
Michael J. Fray - New York NY
Kenneth Richardson - New York NY
John Steele - New York NY

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D40110
A61K 31415

US Classification:

514338

Abstract:

Platelet activating factor antagonists of formula (I): ##STR1## wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C. sub. 1 -C. sub. 4 alkyl, C. sub. 1 -C. sub. 4 alkoxy, aryl(C. sub. 1 -C. sub. 4)alkoxy, fluoro(C. sub. 1 -C. sub. 4)alkoxy, C. sub. 1 -C. sub. 4 alkylthio, C. sub. 1 -C. sub. 4 alkylsulphonyl, hydroxy, trifluoromethyl and cyano, or is phenyl fused to a dioxole ring; R. sup. 1 and R. sup. 2 are each independently H or C. sub. 1 -C. sub. 6 alkyl, or R. sup. 1 and R. sup. 2 together complete a pyrrolidinyl, piperidino, morpholino, piperazinyl, N-(C. sub. 1 -C. sub. 4 alkyl)piperazinyl or N-(C. sub. 2 -C. sub. 4 alkanoyl)-piperazinyl group; R. sup. 2 is H or C. sub. 1 -C. sub. 4 alkyl and R. sup.

US Patent:

46380078, Jan 20, 1987

Filed:

Aug 20, 1984

Appl. No.:

6/642301

Inventors:

Kenneth Richardson - New York NY
Peter J. Whittle - New York NY

Assignee:

Pfizer Inc. - New York NY

International Classification:

A61K 3141
C07D40112
C07D24908

US Classification:

514340

Abstract:

Antifungal 1-[3-(substituted)-2-hydroxy-2-(perfluoroalkyl)-propyl]triazole derivatives wherein the 3-propyl substituent represents optionally substituted phenoxy, heteroaryloxy, alkylthio, alkylsulfinyl, alkylsulfonyl or optionally substituted carbamoyl.