Kenneth W Ryan

US Patent:

6784170, Aug 31, 2004

Filed:

Feb 9, 2001

Appl. No.:

09/780990

Inventors:

Richard H. Peters - San Jose CA
Jyanwei Liu - Sunnyvale CA
John G. Johansson - Menlo Park CA
Kenneth J. Ryan - Sunnyvale CA
Masato Tanabe - Palo Alto CA

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 3156

US Classification:

514182, 514176, 540112, 552558, 552600

Abstract:

Syntheses of steroids such as 3-hydroxy-7-methyl-21-[2â-methoxy-4â-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (âSR 16234â) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.

US Patent:

7772218, Aug 10, 2010

Filed:

Aug 9, 2004

Appl. No.:

10/915302

Inventors:

Richard H. Peters - San Jose CA, US
Jyanwei Liu - Sunnyvale CA, US
John G. Johansson - Menlo Park CA, US
Kenneth J. Ryan - Sunnyvale CA, US
Masato Tanabe - Palo Alto CA, US

Assignee:

SRI International - Menlo Park CA

International Classification:

C07J 41/00
C07J 43/00

US Classification:

514169, 514174, 514178, 552526, 552530, 552531

Abstract:

Syntheses of steroids such as 3-hydroxy-7α-methyl-21-[2′-methoxy-4′-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or intermediate. The latter compound may be readily prepared from estrone-3-methyl ether. Certain intermediates in these syntheses also have value as therapeutic agents, for example in the treatment of prostate disorders such as prostatic cancer.

US Patent:

20130150369, Jun 13, 2013

Filed:

Dec 23, 2012

Appl. No.:

13/726135

Inventors:

Peter Madrid - Saratoga CA, US
Sidharth Chopra - Mountain View CA, US
Kenneth Ryan - Sunnyvale CA, US
Gary Koolpe - Tracy CA, US

Assignee:

SRI INTERNATIONAL - Menlo Park CA

International Classification:

C07D 253/10
C07D 417/04
C07D 403/04
A61K 31/541
A61K 45/06
A61K 31/53
A61K 31/5377
C07D 413/04
C07D 401/04

US Classification:

514243, 544183, 544112, 544 582

Abstract:

Benzotriazine doxides are disclosed as drugs targeting , including novel compounds of formula I:

US Patent:

54280214, Jun 27, 1995

Filed:

Jan 27, 1994

Appl. No.:

8/188579

Inventors:

Charles K. Hiebert - Mountain View CA
Alan Laibelman - Menlo Park CA
Kenneth J. Ryan - Sunnyvale CA

Assignee:

SRI International - Menlo Park CA

International Classification:

A61K 3805
A61K 3806
A61K 31535
C07D26524

US Classification:

514 18

Abstract:

Novel therapeutic agents useful as inhibitors of HLE are provided. The compounds have the structural formula (I) ##STR1## wherein R. sup. 1 through R. sup. 9, m, n and p are as defined herein. Methods of using the compounds of formula (I) to inhibit serine proteases and to treat physiological conditions and disease states associated with elevated HLE levels are also provided, as are pharmaceutical compositions containing the compounds.

US Patent:

40864162, Apr 25, 1978

Filed:

May 17, 1977

Appl. No.:

5/797591

Inventors:

Edward M. Acton - Menlo Park CA
Kenneth J. Ryan - Sunnyvale CA

Assignee:

Stanford Research Institute - Menlo Park CA

International Classification:

C07H 1916

US Classification:

536 24

Abstract:

Septacidin analogs, useful as antitumor agents, having the structure ##STR1## where R is a branched or straight chain alkanoyl group of from 12 to 16 carbon atoms. A preferred compound is 6-[4,6-dideoxy-4-(isopalmitoylglycyl)-amino-. beta. -L-glucopyranosylamino]- 9H-purine.

US Patent:

47058501, Nov 10, 1987

Filed:

Nov 23, 1984

Appl. No.:

6/674175

Inventors:

Edward M. Acton - Menlo Park CA
Kenneth J. Ryan - Sunnyvale CA
Michael Tracy - Menlo Park CA

Assignee:

SRI International - Menlo Park CA

International Classification:

C07H 702
C07H 1524

US Classification:

536 11

Abstract:

Disclosed herein is a new procedure for preparing the C. 1-2,4-pentadienyl derivatives of 2-deoxyhexopyranoses, as well as a new procedure for allylation of daunosamine. These methods are particularly useful for the preparation of intermediates in the synthesis of adriamycin C-glycosidic analogs which are useful anti-tumor agents. These methods provide the first enabling disclosure of methods to prepare these desired adriamycin and anthrocyclinone C-glycosidic analogs.

US Patent:

20170217908, Aug 3, 2017

Filed:

Apr 11, 2017

Appl. No.:

15/484136

Inventors:

Peter Madrid - Saratoga CA, US
Sidharth Chopra - Mountain View CA, US
Kenneth Ryan - Sunnyvale CA, US
Gary Koolpe - Tracy CA, US

Assignee:

SRI INTERNATIONAL - Menlo Park CA

International Classification:

C07D 253/10
A61K 45/06
C07D 403/04
C07D 401/12
C07D 417/04
A61K 31/541
A61K 31/5377
C07D 403/12
A61K 31/53
C07D 401/04

Abstract:

Benzotriazine doxides are disclosed as drugs targeting , including novel compounds of formula I: