Kenneth M Starks

US Patent:

57146152, Feb 3, 1998

Filed:

Feb 8, 1994

Appl. No.:

8/193217

Inventors:

James C. Powers - Atlanta GA
Jerry J. Buccafusco - Evans GA
Kenneth M. Starks - Atlanta GA

Assignee:

Georgia Tech Research Corporation - Atlanta GA

International Classification:

C07D21375
C07D21377
C07D21353
C07D21346

US Classification:

546291

Abstract:

Methods for using novel quaternary pyridinium compounds in inhibiting acetylcholinesterase in mammals, specifically using the quaternary pyridinium compounds in the prophylaxis and treatment of organophosphate poisoning and mammalian dementia by mimicking or opposing the actions of the natural neurotransmitter acetylcholine.

US Patent:

57263140, Mar 10, 1998

Filed:

Sep 30, 1996

Appl. No.:

8/723293

Inventors:

James C. Powers - Atlanta GA
Jerry J. Buccafusco - Evans GA
Kenneth M. Starks - Atlanta GA

Assignee:

Georgia Tech Research Corp. - Atlanta GA

International Classification:

C07D21375
C07D21365
C07D21372

US Classification:

546292

Abstract:

Novel quaternary pyridinium compounds useful in inhibiting acetylcholinesterase in mammals of the general structure: ##STR1## or pharmaceutically acceptable salts thereof, where R. sub. 5 is pentafluorophenyl, phenyl monosubstituted with K, phenyl disubstituted with K, phenyl trisubstituted with K, or naphthyl; R. sub. 6 is H, C. sub. 1-6 alkyl, phenyl, pentafluorophenyl, phenyl mono, di, or trisubstituted with K, C. sub. 1-6 alkyl with an attached phenyl group, C. sub. 1-6 alkyl with an attached phenyl group mono, di, or trisubstituted with K; K is halogen, COOH, OH, CN, NO. sub. 2, NH. sub. 2, C. sub. 1-6 alkyl, C. sub. 1-6 fluorinated alkyl, C. sub. 1-6 alkoxy, C. sub. 1-6 alkylamine, C. sub. 1-6 alkyl--O--CO--, C. sub. 1-6 alkyl--CO--NH--, C. sub.