Kevin M Chapman

US Patent:

8155127, Apr 10, 2012

Filed:

Nov 10, 2006

Appl. No.:

11/595719

Inventors:

Scott Y. Seidel - Fairfax VA, US
Roberto Berezdivin - Great Falls VA, US
Jay N. Livingston - Oakton VA, US
Robert J. Breinig - Warrenton VA, US
Gary A. Luethke - Oakton VA, US
Darrell L. Young - Falls Church VA, US
Timothy C. Brannan - Chantilly VA, US
Tin T Ho - Springfield VA, US
Kevin L. Chapman - Vienna VA, US
Stephen P. Hershey - Sarasota FL, US

Assignee:

Powerwave Cognition, Inc. - Santa Ana CA

International Classification:

H04L 12/28
H04L 12/56
H04W 4/00

US Classification:

370400, 370254, 370338, 370343, 455522

Abstract:

Communicating between a plurality of nodes includes: at one or more of the plurality of nodes, sensing spectrum activity on at least one channel; creating and maintaining at least one spectrum awareness table based at least in part on the sensed spectrum activity, determining at least one selected bearer based on the at least one spectrum awareness table; performing an adaptive control channel initialization operation to detect zero or more neighbor nodes.

US Patent:

20210270817, Sep 2, 2021

Filed:

Mar 11, 2021

Appl. No.:

17/198833

Inventors:

- Emeryville CA, US
Troy A. Lionberger - San Francisco CA, US
Kevin T. Chapman - Emeryville CA, US

Assignee:

Berkeley Lights, Inc. - Emeryville CA

International Classification:

G01N 33/53
B01L 3/00

Abstract:

Disclosed herein is a method for assaying binding affinity between a first molecule and a second molecule in a micro-fluidic device.

US Patent:

20210087252, Mar 25, 2021

Filed:

Aug 7, 2020

Appl. No.:

16/987835

Inventors:

- Emeryville CA, US
- Oakland CA, US
Payal Watchmaker - San Francisco CA, US
Yelena Bronevetsky - Alameda CA, US
Ryosuke Naka - San Francisco CA, US
Guido K. Stadler - San Francisco CA, US
Xiaohua Wang - Pomona NY, US
Kevin T. Chapman - Emeryville CA, US

Assignee:

Berkeley Lights, Inc. - Emeryville CA
The Regents of the University of California - Oakland CA

International Classification:

C07K 14/725
C12N 5/0783
C12N 15/63

Abstract:

This disclosure relates to the production and use of an isolated, purified and/or recombinant T cell receptor (TCR) that specifically binds to a mutant IDH1 protein, or a fragment thereof, wherein the mutant IDH1 protein or fragment thereof comprises an R132H mutation.

US Patent:

20210069698, Mar 11, 2021

Filed:

Jul 14, 2020

Appl. No.:

16/928225

Inventors:

- Emeryville CA, US
Mark P. White - San Francisco CA, US
Jason M. McEwen - El Cerrito CA, US
Gang F. Wang - Mountain View CA, US
Kevin T. Chapman - Santa Monica CA, US
Xiaohua Wang - Albany CA, US
Christine E. Sun - Emeryville CA, US

International Classification:

B01L 3/00
C12M 1/02
C12M 1/34
C12M 1/36
C12M 1/00
C12M 3/06
C12Q 1/02
G01N 33/50

Abstract:

Functional assays using reporter cell assays are described which probe the activity of at least one cell of interest. The ability to probe at least one cell is provided by using the microfluidic methods, devices and kits described herein. Assays combining both reporter cell signaling as well as binding assay signaling for at least one cell is also described herein.

US Patent:

20210071124, Mar 11, 2021

Filed:

Jul 2, 2020

Appl. No.:

16/920365

Inventors:

- Emeryville CA, US
Kristin G. BEAUMONT - Oakland CA, US
Aathavan KARUNAKARAN - Berkeley CA, US
Natalie C. MARKS - Albany CA, US
Jason M. MCEWEN - El Cerrito CA, US
Mark P. WHITE - San Francisco CA, US
J. Tanner NEVILL - El Cerrito CA, US
Gang F. WANG - Mountain View CA, US
Andrew W. MCFARLAND - Berkeley CA, US
Daniele Malleo - San Jose CA, US
Keith J. BREINLINGER - San Rafael CA, US
Xiao GUAN - San Rafael CA, US
Kevin T. CHAPMAN - Santa Monica CA, US

International Classification:

C12M 3/06
C12M 1/00

Abstract:

Systems, methods and kits are described for culturing one or more biological cells in a microfluidic device, including provision of nutrients and gaseous components configured to enhance cell growth, viability, portability, or any combination thereof. In some embodiments, culturing a single cell may produce a clonal population in the microfluidic device.

US Patent:

20200392567, Dec 17, 2020

Filed:

Jun 24, 2020

Appl. No.:

16/910682

Inventors:

- Emeryville CA, US
Ravi K. Ramenani - Livermore CA, US
Debjit Ray - Santa Clara CA, US
Thomas M. Vetterli - Berkeley CA, US
Annamaria Mocciaro - San Francisco CA, US
Magali Soumillon - Boston MA, US
Mark P. White - Orinda CA, US
Troy A. Lionberger - Berkeley CA, US
Kevin T. Chapman - Emeryville CA, US
Po-Yuan Tung - South San Francisco CA, US

Assignee:

Berkeley Lights, Inc. - Emeryville CA

International Classification:

C12Q 1/6809
B01J 19/00
B01L 3/00
C12Q 1/6806
C12Q 1/6841

Abstract:

Disclosed herein are methods for performing assays, including general functional assays, on a biological cell. The methods can include contacting a biological cell with a test agent for a period of time; lysing the biological cell while the biological cell is disposed within a sequestration pen located within an enclosure of a microfluidic device; and allowing RNA molecules released from the lysed biological cell to be captured by capture oligonucleotides linked to a capture object disposed within the sequestration pen of the microfluidic device. Each capture oligonucleotide can include a priming sequence that binds a primer, and a capture sequence. Each cDNA transcribed from a captured RNA can have an oligonucleotide sequence complementary to the captured RNA molecule, with the complementary oligonucleotide sequence being covalently linked to one of the capture oligonucleotides of the capture object.

US Patent:

20200299351, Sep 24, 2020

Filed:

Jan 15, 2020

Appl. No.:

16/743849

Inventors:

- Emeryville CA, US
Alexander J. Mastroianni - Alameda CA, US
Shao Ning Pei - Albany CA, US
Annamaria Mocciaro - San Francisco CA, US
Kevin D. Loutherback - Rochester MN, US
Yelena Bronevetsky - Alameda CA, US
Guido K. Stadler - San Francisco CA, US
Andrew W. McFarland - Berkeley CA, US
Kevin T. Chapman - Emeryville CA, US
Duane Smith - Berkeley CA, US
Natalie C. Marks - Albany CA, US
Amanda L. Goodsell - Alameda CA, US

Assignee:

Berkeley Lights, Inc. - Emeryville CA

International Classification:

C07K 14/725
C07K 16/28
G01N 33/50
C07K 14/74

Abstract:

In biosciences and related fields, it can be useful to modify surfaces of apparatuses, devices, and materials that contact biomaterials such as biomolecules and biological micro-objects. Described herein are surface modifying and surface functionalizing reagents, preparation thereof, and methods for modifying surfaces to activate T Lymphocytes.

US Patent:

20200139362, May 7, 2020

Filed:

Oct 17, 2019

Appl. No.:

16/656520

Inventors:

- Emeryville CA, US
Alexander J. MASTROIANNI - Alameda CA, US
Shao Ning PEI - Albany CA, US
Annamaria MOCCIARO - San Francisco CA, US
Kevin D. LOUTHERBACK - Berkeley CA, US
Yelena BRONEVETSKY - Alameda CA, US
Guido K. STADLER - San Francisco CA, US
Andrew W. MCFARLAND - Berkeley CA, US
Kevin T. CHAPMAN - Emeryville CA, US
Duane SMITH - Berkeley CA, US
Natalie C. MARKS - Albany CA, US
Amanda L. GOODSELL - Alameda CA, US

Assignee:

Berkeley Lights, Inc. - Emeryville CA

International Classification:

B01L 3/00
C07K 14/74
G01N 33/68
G01N 33/50

Abstract:

Proto-antigen-presenting surfaces and related kits, methods, and uses are provided. The proto-antigen-presenting surface can comprise a plurality of primary activating molecular ligands comprising a major histocompatibility complex (MHC) molecule configured to bind to a T cell receptor (TCR) of a T cell and a plurality of of co-activating molecular ligands each including a TCR co-activating molecule or an adjunct TCR activating molecule, wherein an exchange factor is bound to the MHC molecules. Exchange factors include, e.g., dipeptides such as GL, GF, GR, etc. Proto-antigen-presenting surfaces can be used to rapidly prepare antigen-presenting surfaces comprising one or more peptide antigens of interest by contacting the proto-antigen-presenting surface with one or more peptide antigens so as to displace the exchange factor. As such, the disclosure facilitates rapid evaluation of the immunogenicity of peptide antigens for activating T lymphocytes.