Kevin M Daly

US Patent:

20090270450, Oct 29, 2009

Filed:

May 5, 2009

Appl. No.:

12/435856

Inventors:

Leslie Dakin - Waltham MA, US
Kevin Daly - Waltham MA, US
David Del Valle - Austin TX, US
Thomas Gero - Waltham MA, US
Claude Afona Ogoe - Waltham MA, US
David Scott - Waltham MA, US
Xiaolan Zheng - Waltham MA, US

Assignee:

ASTRAZENECA AB - Sodertalje

International Classification:

A61K 31/47
C07D 215/44

US Classification:

514313, 546160

Abstract:

The invention relates to chemical compounds of formula (I):or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

US Patent:

20090275570, Nov 5, 2009

Filed:

Apr 5, 2006

Appl. No.:

11/910358

Inventors:

Kevin Daly - Waltham MA, US
Nicola Heron - Macclesfield, GB
Alexander Hird - Waltham MA, US
Stephanos Ioannidis - Waltham MA, US
James Janetka - Waltham MA, US
Paul Lyne - Waltham MA, US
Jaime Scott - Macclesfield, GB
Dorin Toader - Waltham MA, US
Melissa Vasbinder - Waltham MA, US
Dingwei Yu - Waltham MA, US
Yan Yu - Waltham MA, US

Assignee:

ASTRAZENECA AB - Sodertalje

International Classification:

A61K 31/538
C07D 495/04
A61K 31/4365
A61K 31/5377
A61P 35/00
A61K 31/454
C07D 401/12

US Classification:

5142305, 546114, 514301, 5142338, 544127, 544105, 514323, 546201

Abstract:

The invention relates to novel compounds of Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds possess CHK1 kinase inhibitory activity, PDK1 inhibitory activity and Pak kinase inhibitory activity and are accordingly useful in the treatment and/or prophylaxis of cancer.

US Patent:

20110190272, Aug 4, 2011

Filed:

May 6, 2009

Appl. No.:

12/990711

Inventors:

Kevin Daly - Waltham MA, US
Del Valle David - Waltham MA, US
David Scott - Waltham MA, US
Qing Ye - Waltham MA, US

Assignee:

ASTRAZENECA AB - Sodertalje

International Classification:

A61K 31/551
C07D 237/28
A61K 31/502
C07D 403/12
C07D 401/12
C07D 413/12
A61K 31/5377
A61P 35/00

US Classification:

514218, 544235, 514248, 540575, 544119, 5142345

Abstract:

The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof which possess CSF-IR kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm-blooded animal such as man.

US Patent:

54558700, Oct 3, 1995

Filed:

Jun 24, 1994

Appl. No.:

8/265567

Inventors:

Dinyar Sepai - Framingham MA
Kevin R. Daly - Stow MA
Brian L. Whalen - Grafton MA
Khanh Hong - Ashland MA
George B. Jones - Stow MA

Assignee:

Raytheon Company - Lexington MA

International Classification:

G06K 900
G01N 2132

US Classification:

382147

Abstract:

An automated electronic module inspection system having illumination sources that produce digitized gray scale images that are then analyzed by a computer. The inspection system illuminates the module including solder joints, components and printed circuit board using a sequence of illumination that produce visual images which are used to identify defects. The inspection system inspects for all defects as specified in MIL-STD-2000A (Section 4. 4) by using both surface reflectance properties as well as topological properties of objects. The system comprises two video cameras. A positioning table aligns a module-under-test with the optical axis of each camera thereby enabling the same field-of-view to be observed under different lighting conditions. A dark field illumination associated with a first camera preferentially illuminates non-flat surfaces, but not vertical surfaces. A bright field illumination associated with a second camera preferentially illuminates relatively flat surfaces.

US Patent:

43272770, Apr 27, 1982

Filed:

May 19, 1980

Appl. No.:

6/150768

Inventors:

Kevin R. Daly - Stow MA

Assignee:

Raytheon Company - Lexington MA

International Classification:

B23K 2600
B23K 112

US Classification:

219121LD

Abstract:

A method for simultaneously soldering the two solder covered ends of an electronic chip component to respective conductor pads. Pulsed coherent laser radiation having a predetermined energy profile is separated into two spacially separate beams and they are respectively directed toward the opposing ends of the chip to reflow the solder.

US Patent:

20140199781, Jul 17, 2014

Filed:

Mar 8, 2012

Appl. No.:

14/003313

Inventors:

David M. Briscoe - Sharon MA, US
Kevin P. Daly - Needham MA, US
Ananth Karumanchi - Chestnut Hill MA, US
Michael Seifert - Clayton MO, US

Assignee:

Beth Israel Deaconess Medical Center, Inc. - Boston MA
Children's Medical Center Corporation - Boston MA

International Classification:

G01N 33/536

US Classification:

436501

Abstract:

Presented herein are methods of diagnosing or assessing an individual at increased risk of developing chronic rejection, or chronic allograft vasculopathy, based on analysis the individual's biomarker profile.