David Nilson - Walnut Creek CA, US Michael D. Cable - Danville CA, US Bradley W. Rice - Danville CA, US Kevin Kearney - Fairport NY, US
Assignee:
Xenogen Corporation - Alameda CA
International Classification:
H04N 5/222 A61B 6/00
US Classification:
348370, 600476
Abstract:
The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.
3-D In-Vivo Imaging And Topography Using Structured Light
Bradley W. Rice - Danville CA, US Michael D. Cable - Danville CA, US Kevin Kearney - Fairport NY, US
Assignee:
Xenogen Corporation - Alameda CA
International Classification:
A61B 6/03 A61B 6/12
US Classification:
600473, 600425, 600476, 25036301, 2503171, 382128
Abstract:
The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.
David Nilson - Walnut Creek CA, US Michael D. Cable - Danville CA, US Bradley W. Rice - Danville CA, US Kevin Kearney - Fairport NY, US
Assignee:
Xenogen Corporation - Alameda CA
International Classification:
H04N 5/225 A61B 6/00
US Classification:
348374, 600476
Abstract:
The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.
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