Kevin R Mccarthy

US Patent:

6635098, Oct 21, 2003

Filed:

Feb 12, 2002

Appl. No.:

10/072875

Inventors:

Stanley Abkowitz - Lexington MA
Susan M. Abkowitz - Winchester MA
Harold L. Heussi - Essex MA
Kevin M. McCarthy - Billerica MA

Assignee:

Dynamet Technology, Inc. - Burlington MA

International Classification:

B22F 315

US Classification:

75245, 75235, 75236, 75244, 419 12, 419 13, 419 14, 419 19, 419 28, 419 42, 419 48

Abstract:

A low cost titanium, titanium alloy material, or Ti matrix composite comprising clean and divided titanium turnings that are blended with titanium, titanium alloy powder, and/or ceramic powder and consolidated is provided. A method of making the material is also provided. The low cost material is formed into preshapes, such as a billet, which is subsequently used as feedstock for extrusion, forging, casting, or rolling.

US Patent:

20080070268, Mar 20, 2008

Filed:

Apr 21, 2007

Appl. No.:

11/788872

Inventors:

Karin Anderson - Georgetown MA, US
Niall Barron - Shankill, IE
Timothy Charlebois - Andover MA, US
Martin Clynes - Clontarf, IE
Dana Di Nino - North Andover MA, US
Padraig Doolan - Swords, IE
Patrick Gammell - Naas, IE
Kathleen Kopycinski - Somerville MA, US
Mark Leonard - Manchester NH, US
Kevin McCarthy - North Andover MA, US
Paula Meleady - Ratoath, IE
Mark Melville - Melrose MA, US
Martin Sinacore - Andover MA, US

Assignee:

Wyeth - Madison NJ
Dublin City University - Dublin

International Classification:

C07H 21/04
C07K 16/00
C12N 5/04
C12Q 1/20

US Classification:

435029000, 435325000, 435375000, 530350000, 536022100

Abstract:

The present invention provides methods for systematically identifying genes and proteins and related pathways that maximize protein expression and secretion by expression profiling analysis. The present invention further provides methods for manipulating the identified genes and proteins to engineer improved cell lines.

US Patent:

20090017460, Jan 15, 2009

Filed:

Jun 13, 2008

Appl. No.:

12/139294

Inventors:

Karin Anderson - Georgetown MA, US
Niall Barron - Shankill, IE
Martin Clynes - Clontarf, IE
Dana L. Di Nino - North Andover MA, US
Padraig Doolan - Swords, IE
Patrick Gammell - Naas, IE
Kathleen Kopycinski - Somerville MA, US
Kevin M. McCarthy - North Andover MA, US
Paula Meleady - Ratoath, IE
Mark Melville - Melrose MA, US
Ryan Nolan - Stoneham MA, US

Assignee:

Wyeth - Madison NJ
Dublin City University - Dublin

International Classification:

C12Q 1/68
C12N 5/10

US Classification:

435 6, 435375, 435325

Abstract:

The present invention provides, among other things, systems and methods for identifying genes and proteins that regulate and/or are indicative of cell phenotypes based on expression profiling analysis. The present invention further provides methods of manipulating identified genes and proteins to engineer improved cell lines.

US Patent:

20090280559, Nov 12, 2009

Filed:

May 1, 2009

Appl. No.:

12/434425

Inventors:

Kevin McCarthy - Plaistow NH, US

Assignee:

KOLLMORGEN CORPORATION - Northampton MA

International Classification:

C12M 1/00
G05B 19/40
G02B 27/10
G03B 13/34

US Classification:

4352872, 318685, 359629, 396133

Abstract:

A fluorescence microscopy sequencer comprises a fluid transport subsystem in which reagents are pumped through a series of multi-port valves to a mixer or one or more flow cells, or directly into the flow cell(s). The one or more multi-port valves can be mounted upon a fluids manifold having syringe tubes mounted on the opposite side. Mounted on a movable support, the manifold may be brought into and out of fluid communication with a storage block comprising the plurality of reagents. In another embodiment, the sequencer comprises a beamsplitter indexer that facilitates the quick and reliable switching of filter cubes through use of a stepper motor. In yet another embodiment, a motion control system is provided in which an inertial reference is interposed between and directly coupled to a first and second axis of control, thereby minimizing any low structural resonant frequencies and enabling high performance (high frequency response) motion control.

US Patent:

20100132059, May 27, 2010

Filed:

Nov 10, 2009

Appl. No.:

12/615710

Inventors:

Kevin Michael MCCARTHY - Haverhill MA, US
Robin Allison Heller-Harrison - Andover MA, US
Mark William Leonard - Manchester NH, US
Timothy Shea Charlebois - Andover MA, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A01K 67/00
C07K 2/00
C12N 5/10
C07H 21/00
C07H 21/04
C12N 15/74

US Classification:

800 13, 530300, 536 231, 435358, 536 245, 536 235, 536 241, 4353201

Abstract:

The present invention is based on the discovery that the transcriptional activity of both hamster mammary tumor 7 (HMT-7) and hamster layilin genes are increased when Chinese Hamster Ovary (CHO) cells are cultured at temperatures lower than 37 C. The present invention provides novel genomic, cDNA, and protein sequences of HMT-7 and a novel genomic sequence for hamster layilin. Included in the genomic sequences are novel temperature-induced promoter sequences for each; two promoter sequences are provided for HMT-7 and one promoter sequence is provided for layilin. The invention additionally provides antisense and siRNA molecules to the nucleic acid molecules of HMT-7. The invention also provides genetically engineered expression vectors comprising the novel temperature-induced promoters of the invention, which are particularly useful as part of a mammalian temperature-inducible expression system. The invention also provides host cells and/or transgenic animals comprising the novel nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention, e.g., for temperature-induced transgene expression.

US Patent:

20110014624, Jan 20, 2011

Filed:

Mar 12, 2009

Appl. No.:

12/921717

Inventors:

Kevin Michael McCarthy - Haverhill MA, US
Megan Jill Hone - Hudson NH, US
Robin Allison Heller-Harrison - Andover MA, US
Mark William Leonard - Manchester NH, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

C12Q 1/68
C12N 5/071

US Classification:

435 6, 435325

Abstract:

The present invention provides methods of identifying a clonal population of cells suitable for large-scale production of a protein of interest. The invention further provides methods for high-throughput screening for genetic rearrangements in the gene encoding the protein of interest, whereby the absence of a deletion in the gene encoding the protein of interest indicates that the cell is suitable for large-scale production of the protein of interest.

US Patent:

20180241325, Aug 23, 2018

Filed:

Feb 21, 2018

Appl. No.:

15/901859

Inventors:

- San Diego CA, US
Kevin McCarthy - Plaistow NH, US

International Classification:

H02P 5/68
H02K 41/035
H02K 5/173
H02K 11/22
H02K 11/33
H02P 7/025

Abstract:

A dual axis linear motion system utilizing one or more printed circuit boards embedded within a stage wherein the system components, including the controller, drive, and controller, may be mounted to a printed circuit board (PCB), and the electrical communications between the system components and the power to the system components are supplied through traces or etchings on the printed circuit board, thereby omitting the need for additional power and communication cables.