Kevin R Quick

US Patent:

20030162837, Aug 28, 2003

Filed:

Feb 23, 2002

Appl. No.:

10/083283

Inventors:

Laura Dugan - St. Louis MO, US
Eva Lovett - University City MO, US
Kevin Quick - Florissant MO, US
Joshua Hardt - Belleville IL, US

International Classification:

A61K031/19

US Classification:

514/574000

Abstract:

The instant invention is a method for increasing a metazoan's lifespan, comprising administering a carboxylated derivative of a Cfullerene. The instant invention further is a process for extending a metazoan's lifespan by administering a superoxide dismutase-mimetic as well as a composition comprising a superoxide dismutase-mimetic. Further, the instant invention comprises a pharmaceutical composition comprising carboxyfullerenes having x pairs of adjacent carbon atoms bonded to two carbons of the Csphere wherein said adjacent carbon atom is further bonded to two groups of the general formula —COOH and —R, wherein R is independently selected from the group consisting of —COOH and —H, and wherein x is at least 1. A further embodiment is a non-metal containing composition which can catalytically eliminate two biologically reactive species. Another embodiment is a method of enhancing elimination of reactive oxygen species in eukaryotic cells by contacting cells with a superoxide dismutase mimetic.

US Patent:

20040034100, Feb 19, 2004

Filed:

Feb 24, 2003

Appl. No.:

10/373425

Inventors:

Laura Dugan - St.Louis MO, US
Eva Lovett - University City MO, US
Kevin Quick - Florissant MO, US
Joshua Hardt - Belleville IL, US

International Classification:

A61K031/192
C07C063/48

US Classification:

514/569000, 562/488000

Abstract:

Disclosed and claimed herein are e,e,e malonic acid/acetic acid tri-adduct of buckminsterfullerene of the general formula CR, wherein each R is independently selected from groups of the formula —CRRwherein each Rand Ris independently selected from the group consisting of —H and —COOH, provided, however, that at least one of the R's and R's is a hydrogen. Processes for preparing and uses of the same for treating neuronal injury and for life-extension are also disclosed and claimed herein.