Kevin W Roth

US Patent:

20080221150, Sep 11, 2008

Filed:

Aug 14, 2006

Appl. No.:

12/063715

Inventors:

John J. Shacka - Birmingham AL, US
Kevin A. Roth - Birmingham AL, US

International Classification:

A61K 31/335
A61K 31/47
A61K 31/4375
A61P 25/00

US Classification:

514300, 514450, 514313

Abstract:

The present disclosure describes the use of macrolide antibiotics to prevent neurodegeneration and to treat or prevent disease and conditions which involve neurodegeneration. While not being limited to a specific mechanism of action, in one embodiment, the macrolide antibiotics inhibit neurodegeneration caused by lysosomal and/or mitochondrial dysfunction. The present disclosure contemplates the use of any macrolide antibiotic and pharmaceutically acceptable derivatives thereof. In a specific embodiment, the macrolide antibiotics include bafilomycin A1, bafilomycin B1 and concanamycin.

US Patent:

20110064721, Mar 17, 2011

Filed:

Jul 2, 2008

Appl. No.:

12/667832

Inventors:

Jianhua Zhang - Birmingham AL, US
Guy Caldwell - Northport AL, US
Kevin Roth - Birmingham AL, US
David Standaert - Birmingham AL, US
Kim Cladwell - Northport AL, US
Shusei Hamamichi - Tuscaloosa AL, US

Assignee:

THE UAB RESEARCH FOUNDATION - Birmingham AL
THE UNIVERSITY OF ALABAMA - Tuscaloosa AL

International Classification:

A61K 39/395
C12Q 1/37
A61K 38/02
A61P 25/28
A61P 25/16
A61K 31/7088
C12Q 1/68
A61K 38/48

US Classification:

4241301, 435 23, 514 178, 514 44 R, 435 6, 424 9466, 514 177

Abstract:

Provided herein are methods and compositions for promoting neuroprotection in a subject and for treating a neural disorder associated with protein aggregation comprising administering to the subject an agent that increases expression or activity of cathepsin-D. Also provided are methods of screening for agents that increase expression or activity of cathepsin-D and methods of screening for neuroprotective agents.