Kimberly Sue Hamad

US Patent:

20020061588, May 23, 2002

Filed:

Jul 13, 2001

Appl. No.:

09/905832

Inventors:

Joseph Jacobson - Newton MA, US
John Schwartz - Newtonville MA, US
Kimberly Hamad - Cambridge MA, US
Shuguang Zhang - Lexington MA, US

International Classification:

C12N015/01
C12P019/34

US Classification:

435/446000

Abstract:

Methods and compositions for rendering nucleic acids directly responsive to an external signal utilizing modulators that themselves respond to the external signal and are associated with the nucleic acid. In response to the external signal, the modulator alters physical properties of the specific nucleic acid molecule(s) with which it is associated, thereby altering the structural and functional properties thereof. The modulator may, for example, transfer applied energy to a nucleic acid, or to a portion of the nucleic acid, thereby changing the nucleic acid structure.

US Patent:

20020119572, Aug 29, 2002

Filed:

Jul 13, 2001

Appl. No.:

09/905831

Inventors:

Joseph Jacobson - Newton MA, US
John Schwartz - Newtonville MA, US
Kimberly Hamad - Cambridge MA, US
Shuguang Zhang - Lexington MA, US

International Classification:

C12N015/87

US Classification:

435/466000

Abstract:

Methods and compositions for rendering proteins directly responsive to an external signal utilizing modulators that themselves respond to the external signal and are associated with the proteins. In response to the external signal, the modulator alters physical properties of the specific protein molecule(s) with which it is associated, thereby altering the structural and functional properties thereof. The modulator may, for example, transfer applied energy to a protein, or to a portion of the protein, thereby changing the protein structure and function.