Kimberly Ann Kelly

US Patent:

7452965, Nov 18, 2008

Filed:

Apr 7, 2003

Appl. No.:

10/510155

Inventors:

Kimberly A. Kelly - Burlington MA, US
David A. Jones - Salt Lake City UT, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

A61K 38/12

US Classification:

530317, 514 12

Abstract:

Phage display was used to screen peptide libraries that distinguish between well-differentiated (HCT116) and poorly-differentiated colon carcinoma cells (HT29). The screening protocol used selection and subtraction on intact, viable cells, resulting in phage libraries exhibiting high binding selectivity for the poorly-differentiated HT29 cells. A nine amino acid, disulfide-constrained peptide (RPM) was identified that selectively bound and was internalized into colon cancer cells. The peptide may be used to detect colon cancer cells and also may be used to selectively deliver therapeutic agents to the cells.

US Patent:

20100233676, Sep 16, 2010

Filed:

Jun 12, 2008

Appl. No.:

12/663370

Inventors:

Kimberly Kelly - Burlington MA, US
Ralph Weissleder - Peabody MA, US

International Classification:

C12Q 1/04
C07K 5/10
C07K 7/06
C07K 7/08
C07K 14/00
C12Q 1/70
C12N 15/63
C12N 15/85
C12N 15/74
C12N 15/82

US Classification:

435 5, 530330, 530329, 530328, 530327, 530326, 530402, 435 34, 435440, 435455, 435471, 435468

Abstract:

The present invention contemplates strategies comprising small molecule, cell permeable probes that allow site-specific protein labeling for visualizing biological processes. In one embodiment, the present invention contemplates a series of short peptide sequences comprising high affinity binding (i.e., for example, subnanomolar affinity (0.53 nM) for indocyanine fluorochromes. In one embodiment, the peptide sequences comprise a 5 pmol detection limit for indocyanine fluorochromes. In one embodiment, the present invention contemplates methods comprising high affinity peptide-fluorochrome binding pairs in biological applications including, but not limited to, enzyme linked immunoabsorbent assay (ELISA), fluorescence activated cell sorting (FACS), microscopy (i.e., for example scanning electromicroscopy), Western Blots, histochemistry, protein and cell based tracking both in vitro and in vivo.

US Patent:

20110182814, Jul 28, 2011

Filed:

Apr 14, 2009

Appl. No.:

12/937777

Inventors:

Kimberly Kelly - Crozet VA, US
Ralph Weissleder - Peabody MA, US
Nabeel Bardeesy - Framingham MA, US

International Classification:

A61K 49/00
C07K 7/06
A61K 38/08
A61P 35/00
C12Q 1/02
G01N 33/574
B82Y 5/00

US Classification:

424 91, 530329, 514 193, 435 29, 435 723, 977773, 977838, 977834, 977832, 977811, 977927

Abstract:

Described herein are compositions and methods for cancer cell biomarkers, such as pancreatic ductal adenocarcinoma (PDAC) cell biomarkers, and binding molecules for diagnosis and treatment of cancer, e.g., PDAC. Methods of identifying “accessible” proteomes are disclosed for identifying cancer biomarkers, such as plectin-1, a PDAC biomarker. Additionally, imaging compositions are provided comprising magnetofluorescent nanoparticles conjugated to peptide ligands for identifying PDACs.

US Patent:

20120219499, Aug 30, 2012

Filed:

Nov 5, 2010

Appl. No.:

13/508120

Inventors:

Kimberly A. Kelly - Crozet VA, US

Assignee:

UNIVERSITY OF VIRGINIA PATENT FOUNDATION - Charlottesville VA

International Classification:

A61K 51/08
G01N 21/64
A61K 49/00
G01N 24/10
G01N 29/00
C07K 19/00
G01N 33/574
G01N 21/76

US Classification:

424 169, 435 723, 530300, 424 91, 530324, 424 96, 424 95

Abstract:

The present invention provides compositions and methods useful for diagnostic and imaging techniques for detecting and localizing the biomarker Plectin-1. The present invention provides multimeric peptide ligand complexes for targeting Plectin-1, such as the multimeric peptide ligand complex having the formula (βAKTLLPTPGGS(PEG5000))4 KKKKDOTAβA-NH, to which imaging agents and/or therapeutic agents can be conjugated.

US Patent:

20130203045, Aug 8, 2013

Filed:

May 26, 2011

Appl. No.:

13/699983

Inventors:

James P. Landers - Charlottesville VA, US
Kimberly A. Kelly - Crozet VA, US
Jingyi Li - Charlottesville VA, US
Daniel C. Leslie - Brookline MA, US

Assignee:

University of Virginia Patent Foundation - Charlottesville VA

International Classification:

C12Q 1/68
C12Q 1/70

US Classification:

435 5, 435 612, 435 61, 435 611

Abstract:

The invention provides methods to detect or determine the presence or amount of a pathogen, such as a virus or bacterium, in a sample or the amount of cells based on the detection of their genomic DNA. The method employs magnetic substrates and subjects the sample and the magnetic substrate to forms of energy so as to induce aggregate formation and detects the aggregates.

US Patent:

20200268900, Aug 27, 2020

Filed:

Apr 10, 2020

Appl. No.:

16/846031

Inventors:

- Charlottesville VA, US
Kimberly A. Kelly - Goochland VA, US

International Classification:

A61K 47/68
A61K 47/65
A61K 31/282
A61K 31/519
C07K 16/30
A61P 35/00

Abstract:

Aspects of the disclosure provide compositions and methods for treating cancer characterized by surface expression of plectin-1. The disclosure relates, in part, to combinations of therapeutic agents (e.g., anti-plectin-1 antibodies and certain small molecules) that function together (e.g., synergistically) to inhibit cancer cell growth. In some embodiments, the disclosure relates to anti-plectin-1 antibody-drug-conjugates (ADCs).

US Patent:

20180360755, Dec 20, 2018

Filed:

Jun 15, 2016

Appl. No.:

15/737047

Inventors:

- Charlottesville VA, US
Brent A. French - Charlottesville VA, US
Kimberly A. Kelly - Crozet VA, US
Siva Sai Krishna Dasa - Charlottesville VA, US

International Classification:

A61K 9/127
A61K 47/69
A61K 47/62
A61K 9/00
A61P 9/00

Abstract:

Isolated peptides targeting cardiovascular disease are described herein or one or more conservative amino acid substitutions, deletions or additions of such peptides and methods of use thereof for delivering payloads to specific cell types or tissues.

US Patent:

20150374862, Dec 31, 2015

Filed:

Mar 27, 2015

Appl. No.:

14/671062

Inventors:

- Charlottesville VA, US
Kimberly A. Kelly - Crozet VA, US

Assignee:

UNIVERSITY OF VIRGINIA PATENT FOUNDATION - Charlottesville VA

International Classification:

A61K 51/08
A61K 51/04
A61K 51/06
C07K 7/06

Abstract:

The present invention provides compositions and methods useful for diagnostic and imaging techniques for detecting and localizing the biomarker Plectin-1. The present invention provides multimeric peptide ligand complexes for targeting Plectin-1, such as the multimeric peptide ligand complex having the formula (βAKTLLPTPGGS(PEG5000))KKKKDOTAβA-NH, to which imaging agents and/or therapeutic agents can be conjugated.

Address:

1076 Autumn Hl Ct, Crozet, VA 22932

Phone:

4348235579

VIN:

KNAFE121975389707

Make:

KIA

Model:

SPECTRA

Year:

2007