Kimberly Gaye Lane

US Patent:

7747308, Jun 29, 2010

Filed:

Feb 2, 2006

Appl. No.:

11/346527

Inventors:

William Gregory Hundley - Winston-Salem NC, US
Craig A. Hamilton - Lewisville NC, US
Kimberly Lane - Advance NC, US
Tim Morgan - Palmyra VA, US
Frank Torti - Winston-Salem NC, US
Ralph B. D'Agostino - Winston-Salem NC, US

Assignee:

Wake Forest University Health Sciences - Winston-Salem NC

International Classification:

A61B 5/05
G06K 9/00

US Classification:

600414, 382131

Abstract:

Methods, systems and circuits predict cardiotoxicity induced cardiac injury prior to an irreversible state by electronically generating at least one histogram of mean intensities of voxels/pixels in an MRI image of a left ventricle myocardium and electronically determining a likelihood of cardiac injury due to cardiotoxicity based on data from the at least one histogram.

US Patent:

8532739, Sep 10, 2013

Filed:

Jan 24, 2008

Appl. No.:

12/019457

Inventors:

William Gregory Hundley - Winston-Salem NC, US
Craig A. Hamilton - Lewisville NC, US
Kimberly Lane - Advance NC, US
Tim Morgan - Clemmons NC, US
Frank Torti - Winston-Salem NC, US

Assignee:

Wake Forest University Health Sciences - Winston-Salem NC

International Classification:

A61B 5/05

US Classification:

600411, 600407, 600420, 600431, 382170

Abstract:

Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.

US Patent:

20050215883, Sep 29, 2005

Filed:

Feb 4, 2005

Appl. No.:

11/051304

Inventors:

William Hundley - Winston-Salem NC, US
Craig Hamilton - Lewisville NC, US
Kimberly Lane - Advance NC, US
Tim Morgan - Clemmons NC, US
Frank Torti - Winston-Salem NC, US

International Classification:

A61B005/05

US Classification:

600410000, 600411000

Abstract:

Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, for example, after administration of a contrast agent to the patient, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition, for example, after administration of a contrast agent to the patient. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. The region of interest may include heart, blood, muscle, brain, nerve, skeletal, skeletal muscle, liver, kidney, lung, pancreas, endocrine, gastrointestinal and/or genitourinary tissue. A global characteristic of the region of interest of the first image and of the second image is determined to allow a comparison of the global characteristic of the first image and the second image to determine a potential for a change in global tissue characteristics. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.

US Patent:

20130324831, Dec 5, 2013

Filed:

Aug 7, 2013

Appl. No.:

13/961581

Inventors:

Craig A. Hamilton - Lewisville NC, US
Kimberly Lane - Advance NC, US
Tim Morgan - Clemmons NC, US
Frank Torti - Winston-Salem NC, US

International Classification:

A61B 5/00

US Classification:

600407

Abstract:

Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.