Kimberly J Taylor

US Patent:

7754225, Jul 13, 2010

Filed:

Jul 20, 2006

Appl. No.:

11/490512

Inventors:

Ali Fattom - Rockville MD, US
Jawad Sarwar - Germantown MD, US
Zuzana Kossaczka - Bethesda MD, US
Kimberly L. Taylor - Bethesda MD, US
Sofiane Ennifar - Silver Spring MD, US

Assignee:

Glaxosmithkline Biologicals S.A. - Rixensart

International Classification:

A61K 39/385

US Classification:

4242431, 4241931, 42419711, 4242341

Abstract:

A method of preventing or treating staphylococcal bacterial infection in an individual is disclosed. A vaccine based on a conjugate of PS1 polysaccharide antigen can be used for active protection in individuals who are to be subjected to conditions that place them at immediate risk of developing a bacterial infection, as would be case in the context of a catheterization or a surgical procedure. Alternatively, antibodies raised in response to the antigen can be used to treat or to provide passive protection to individuals. The method can be used in a population of patients at risk for infection by various species of or various types of.

US Patent:

20060228368, Oct 12, 2006

Filed:

Apr 7, 2005

Appl. No.:

11/101386

Inventors:

Ali Fattom - Rockville MD, US
Jawad Sarwar - Germantown MD, US
Zuzana Kossaczka - Bethesda MD, US
Kimberly Taylor - Bethesda MD, US
Sofiane Ennifar - Silver Spring MD, US

Assignee:

Nabi Biopharmaceuticals - Boca Raton FL

International Classification:

A61K 39/40
A61K 39/085

US Classification:

424164100, 424243100

Abstract:

A method of preventing or treating staphylococcal bacterial infection in an individual is disclosed. A vaccine based on a conjugate the 336 polysaccharide antigen can be used for active protection in individuals who are to be subjected to conditions that place them at immediate risk of developing a bacterial infection, as would be case in the context of a catheterization or a surgical procedure. Alternatively, antibodies raised in response to the antigen can be used to treat or to provide passive protection to individuals. The method can be used in a population of patients at risk for infection by various species of or various types of

US Patent:

20080131457, Jun 5, 2008

Filed:

Feb 27, 2007

Appl. No.:

11/711164

Inventors:

Kimberly L. Taylor - Bethesda MD, US
Ali I. Fattom - Rockville MD, US

International Classification:

A61K 39/00

US Classification:

4242031

Abstract:

Vaccines comprising an alpha-toxin antigen and a pharmaceutically acceptable carrier are provided, and are useful for treating and preventing infections. The alpha-toxin antigen may contain at least two alterations that reduce its toxicity and/or may be conjugated to or co-administered with another bacterial antigen. The vaccines may comprise one or more other bacterial antigens. Antibody compositions comprising antibodies to alpha-toxin and optionally one or more other bacterial antigens also are provided, and are useful for treating and preventing infections.

US Patent:

20090053235, Feb 26, 2009

Filed:

Feb 27, 2007

Appl. No.:

11/711165

Inventors:

Kimberly L. Taylor - Bethesda MD, US
Ali I. Fattom - Rockville MD, US

International Classification:

A61K 39/395
A61K 39/085

US Classification:

4241501, 4241651, 4242371

Abstract:

Vaccines comprising an alpha-toxin antigen and a pharmaceutically acceptable carrier are provided, and are useful for treating and preventing infections. The alpha-toxin antigen may contain at least two alterations that reduce its toxicity and/or may be conjugated to or co-administered with another bacterial antigen. The vaccines may comprise one or more other bacterial antigens. Antibody compositions comprising antibodies to alpha-toxin and optionally one or more other bacterial antigens also are provided, and are useful for treating and preventing infections.

US Patent:

20090074755, Mar 19, 2009

Filed:

Jun 13, 2006

Appl. No.:

11/451608

Inventors:

Kimberly Louise Taylor - Bethesda MD, US
Ali Ibrahim Fattom - Rockville MD, US

International Classification:

A61K 39/40
C07K 16/12
G01N 33/53
A61P 31/04
C07K 14/31

US Classification:

4241331, 5303895, 5303884, 5303873, 4241651, 435 71, 4241401, 530350

Abstract:

The present invention relates to compositions and methods for treating () infections. In particular, the present invention provides vaccines comprising a Panton-Valentine Leukocidin (u) antigen, antibodies which bind a PVL antigen and compositions containing the same, methods of making such compositions and methods for treating infections, including those that are community acquired methicillin-resistant infections. The present invention also provides PVL antibodies, including PVL antibodies specific for a single PVL subunit, and PVL antigens, including conjugated and mutated PVL antigens.