Krishna C Agrawal

US Patent:

44629923, Jul 31, 1984

Filed:

Feb 8, 1982

Appl. No.:

6/346914

Inventors:

Krishna C. Agrawal - New Orleans LA
Masakazu Sakaguchi - New Orleans LA

Assignee:

Research Corporation - New York NY

International Classification:

A61K 3170
C07H 1908

US Classification:

424180

Abstract:

Compounds of the formula: ##STR1## wherein W is selected from the group consisting of ##STR2## Wherein Q is hydrogen or --CH. sub. 2 OR. sup. 1 ; Z is hydrogen or --OR. sup. 1 ; n is 1 or 2; wherein R. sup. 1 are the same or different radicals selected from the group consisting of hydrogen, and ##STR3## where R. sup. 2 is lower alkyl, aryl, or aralkyl; wherein the bond at positions 2' and 3' of structure I may be single or double; or it may be a C-nucleoside attached at 3' position of the sugar; X and Y are the same or different selected from the group consisting of hydrogen, an electron withdrawing group, and a group wherein X and Y taken together form a 6-membered carbocylic aromatic ring, are useful as radiosensitizing agents during x-ray radiotherapy of tumor cells.

US Patent:

50266888, Jun 25, 1991

Filed:

Oct 31, 1988

Appl. No.:

7/265201

Inventors:

Krishna Agrawal - New Orleans LA

Assignee:

Administrators of the Tulane Educational Fund - New Orleans LA

International Classification:

A61K 3170

US Classification:

514 50

Abstract:

The present invention relates to novel ester derivatives of the anti-retroviral compound AZT, and compositions containing same. It also relates to methods of treatment of retroviral infections comprising administration of said compounds to individuals in need of such treatment.

US Patent:

42822327, Aug 4, 1981

Filed:

Apr 26, 1979

Appl. No.:

6/033513

Inventors:

Krishna C. Agrawal - New Orleans LA

Assignee:

Research Corporation - New York NY

International Classification:

A61K 31415
A61K 31445
C07D40106
C07D40306

US Classification:

424267

Abstract:

Biologically active hypoxic cell radiosensitizers of the formula ##STR1## wherein Z is a C. sub. 2 -C. sub. 4 alkylene group which may be substituted by OH; wherein R. sup. 1 and R. sup. 2 are same or different substituted or unsubstituted C. sub. 1 -C. sub. 4 alkyl groups, or R. sup. 1 and R. sup. 2 taken together with the nitrogen atom form a heterocyclic ring of the formula ##STR2## wherein n=0 or 1, with the condition that when n=0, m=2 or 3 and when n=1, m=1 or 2; X and Y are hydrogen, an electron withdrawing group or X and Y taken together form a six-membered carboxylic aromatic ring.