Kristen K Briggs

US Patent:

7176349, Feb 13, 2007

Filed:

Sep 29, 2000

Appl. No.:

10/089281

Inventors:

Kanwarpal S. Dhugga - Johnston IA, US
Chun Ping Li - Johnston IA, US
Jian G. Dong - Johnston IA, US
William D. Hitz - Wilmington DE, US
Matthias Liebergesell - West Des Moines IA, US
Scott E. Nichols - Westchester PA, US
Kristen K. Briggs - Del Mar CA, US

Assignee:

Pioneer Hi-Bred International, Inc. - Johnston IA
E.I. du Pont de Nemours and Company - Wilmington DE

International Classification:

C12N 15/29
C12N 15/52
C12N 15/63
C12N 15/82

US Classification:

800281, 800287, 800298, 8003201, 536 232, 536 236, 435419, 4353201

Abstract:

The invention relates to the genetic manipulation of plants to produce polyhydroxyalkanoate, particularly in the peroxisomes. Methods for producing such polymers in plants and host cells are provided. Such methods find use in producing biodegradable thermoplastics in plants and other organisms. Nucleotide molecules, expression cassettes, and genetically manipulated host cells, plants, plant tissues, and seeds are also provided.

US Patent:

7276342, Oct 2, 2007

Filed:

Jul 31, 2002

Appl. No.:

10/485233

Inventors:

John Lucas - Concord MA, US
Deno P. Dialynas - San Diego CA, US
Kristen Briggs - Del Mar CA, US

Assignee:

Serono Genetics Institute S.A. - Evry

International Classification:

G01N 33/53
C07K 14/00
A61K 38/00

US Classification:

435 71, 530350, 514 12

Abstract:

The present invention relates to the field of metabolic research, in particular the discovery of compounds effective for reducing body mass and useful for treating obesity-related diseases and disorders. The obesity-related diseases or disorders envisioned to be treated by the methods of the invention include, but are not limited to, hyperlipidemia, atherosclerosis, insulin resistance, diabetes, and hypertension. In particular, the invention provides for methods of identifying and using AGONISTS and ANTAGONISTS of XOBESIN activity, wherein said activity is selected from the group consisting of lipid partitioning, lipid metabolism, and insulin-like activity.

US Patent:

7341856, Mar 11, 2008

Filed:

Jul 17, 2006

Appl. No.:

11/487811

Inventors:

Kanwarpal S. Dhugga - Johnston IA, US
Chun Ping Li - Johnston IA, US
Jian G. Dong - Johnston IA, US
William D. Hitz - Wilmington DE, US
Matthias Liebergesell - West Des Moines IA, US
Scott E. Nichols - Westchester PA, US
Kristen K. Briggs - Del Mar CA, US

Assignee:

Pioneer Hi-Bred International, Inc. - Johnston IA
E.I. du Pont de Nemours and Company - Wilmington DE

International Classification:

C12N 9/00
C07H 21/04

US Classification:

435183, 536 232

Abstract:

The invention relates to the genetic manipulation of plants to produce polyhydroxyalkanoate, particularly in the peroxisomes. Methods for producing such polymers in plants and host cells are provided. Such methods find use in producing biodegradable thermoplastics in plants and other organisms. Nucleotide molecules, expression cassettes, and genetically manipulated host cell, plants, plant tissues, and seeds are also provided.

US Patent:

7344843, Mar 18, 2008

Filed:

Oct 14, 2002

Appl. No.:

10/496757

Inventors:

John Lucas - Concord MA, US
Deno Dialynas - San Diego CA, US
Kristen Briggs - Del Mar CA, US

Assignee:

Serono Genetics Institute S.A. - Evry

International Classification:

G01N 33/53

US Classification:

435 71, 530350

Abstract:

The present invention relates to the field of metabolic research, in particular the discovery of compounds effective for reducing body mass and useful for treating obesity-related diseases and disorders. The obesity-related diseases or disorders envisioned to be treated by the methods of the invention include, but are not limited to, hyperlipidemia, atherosclerosis, insulin resistance, diabetes, and hypertension. In particular, the invention provides for methods of identifying and using AGONISTS and ANTAGONISTS of PROLIXIN activity, wherein said activity is selected from the group consisting of lipid partitioning, lipid metabolism, and insulin-like activity.

US Patent:

8106169, Jan 31, 2012

Filed:

Nov 28, 2003

Appl. No.:

10/536875

Inventors:

Kristen Briggs - Del Mar CA, US
Todd Glancy - Fairmont IN, US
Mich B. Hein - Chicago IL, US
Andrew C. Hiatt - San Diego CA, US
Anton S. Karnoup - Midland MI, US
W. H. Kerr Anderson - Midland MI, US
Dayakar Pareddy - Carmel IN, US
Joseph Petolino - Zionsville IN, US
Beth Rubin-Wilson - Indianapolis IN, US
Doug Taylor - San Diego CA, US
Jean L. Roberts - Arcadia IN, US

Assignee:

Phyton Holdings, LLC - San Antonio TX

International Classification:

C07K 16/08
C07K 16/00
C12N 15/82

US Classification:

5303883, 5303881, 5303871, 435 696

Abstract:

This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli; transformed plant tissues (e. g. , leaves, seeds, tubers, etc. ); transformed whole plants used to produce such immunoglobulins; methods of producing the immunoglobulins; the immunoglobulins produced by the disclosed methods; and the use of such immunoglobulins.

US Patent:

20030092620, May 15, 2003

Filed:

Jul 22, 2002

Appl. No.:

10/202676

Inventors:

John Lucas - San Diego CA, US
Kristen Briggs - Del Mar CA, US

Assignee:

GENSET, S.A. - Paris

International Classification:

A61K038/17

US Classification:

514/012000

Abstract:

The present invention relates to the field of metabolic research. Metabolic disorders, such as obesity, are a public health problem that is serious and widespread. Adipsin polypeptides have been identified that are believed to be beneficial in the treatment of metabolic disorders. These compounds should be effective for reducing body mass and for treating metabolic-related diseases and disorders. These metabolic-related diseases and disorders include hyperlipidemias, atherosclerosis, insulin resistance, diabetes, and hypertension.

US Patent:

20050054565, Mar 10, 2005

Filed:

Jul 29, 2002

Appl. No.:

10/485232

Inventors:

John Lucas - Concord MA, US
Deno Dialynas - San Diego CA, US
Kristen Briggs - Del Mar CA, US

International Classification:

G01N033/53
A61K038/17

US Classification:

514012000, 530324000, 435007100

Abstract:

The present invention relates to the field of metabolic research, in particular the discovery of compounds effective for reducing body mass and useful for treating obesity-related diseases and disorders. The obesity-related diseases or disorders envisioned to be treated by the methods of the invention include, but are not limited to, hyperlipidemia, atherosclerosis, insulin resistance, diabetes, and hypertension. In particular, the invention provides for methods of identifying and using AGONISTS and ANTAGONISTS of MOXIFIN activity, wherein said activity is selected from the group consisting of lipid partitioning, lipid metabolism, and insulin-like activity.

US Patent:

20050065079, Mar 24, 2005

Filed:

Oct 3, 2002

Appl. No.:

10/492179

Inventors:

Aaron Scalia - La Jolla CA, US
Deno Dialynas - San Diego CA, US
Kristen Briggs - Del Mar CA, US

International Classification:

C12Q001/68
A61K038/17
C07K014/705

US Classification:

514012000, 530350000, 435006000, 435069100, 435320100, 435325000, 536023500

Abstract:

The present invention relates to the field of metabolic research. Metabolic disorders, such as obesity, are a public health problem that is serious and widespread. NGZIPA, NGZIPD, PGZIPA or PGZIPD polypeptides have been identified that are believed to be beneficial in the treatment of metabolic disorders. These compounds should be effective for reducing body mass and for treating metabolic-related diseases and disorders. These metabolic-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.