Kristen J Hansen

US Patent:

20130123707, May 16, 2013

Filed:

May 26, 2011

Appl. No.:

13/699805

Inventors:

Amy S. Determan - Woodbury MN, US
Peter R. Johnson - Eagan MN, US
Joan T. Moseman - Lake Elmo MN, US
Ryan T. Woldt - Minneapolis MN, US
Kristen J. Hansen - Afton MN, US

Assignee:

3M INNOVATIVE PROPERTIES COMPANY - ST. PAUL MN

International Classification:

A61K 9/00
A61M 37/00

US Classification:

604173, 427 21

Abstract:

Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100 sand a temperature of 25 C.; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50 or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein.

US Patent:

20140066842, Mar 6, 2014

Filed:

Mar 6, 2012

Appl. No.:

14/003663

Inventors:

Ying Zhang - Woodbury MN, US
Kristen J. Hansen - Afton MN, US
Amy S. Determan - Woodbury MN, US

Assignee:

3M INNOVATIVE PROPERTIES COMPANY - ST. PAUL MN

International Classification:

A61K 9/00
A61M 37/00

US Classification:

604 46, 604512, 427 228

Abstract:

A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocalne, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocalne, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.

US Patent:

20140066843, Mar 6, 2014

Filed:

Mar 6, 2012

Appl. No.:

14/003693

Inventors:

Ying Zhang - Woodbury MN, US
Kristen J. Hansen - Afton MN, US
Amy S. Determan - Woodbury MN, US

Assignee:

3M INNOVATIVE PROPERTIES COMPANY - St. Paul MN

International Classification:

A61K 9/00
A61M 37/00

US Classification:

604 46, 604512, 427 21

Abstract:

A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.

US Patent:

20110213335, Sep 1, 2011

Filed:

Nov 17, 2009

Appl. No.:

13/128066

Inventors:

Scott A. Burton - Woodbury MN, US
Franklyn L. Frederickson - Esko MN, US
Kristen J. Hansen - Afton MN, US
Ryan P. Simmers - Cottage Grove MN, US
Percy T. Fenn - St. Paul MN, US
Craig S. Moeckly - White Bear Lake MN, US

International Classification:

A61M 5/00

US Classification:

604506

Abstract:

Rapid, high-volume, intradermal infusion with minimal pain, is achived by applying an array of 10 to 30 hollow microneedles having a length of greater than 100 um to less than 1 mm into the skin of a patient, with a microneedle spacing of no less than 1.5 mm on average between adjacent microneedles, and pumping greater than 200 uL of fluid through the hollow microneedles at a rate of greater than 20 uL/min.

US Patent:

20210355268, Nov 18, 2021

Filed:

Oct 24, 2019

Appl. No.:

17/287435

Inventors:

- St. Paul MN, US
Kristen J. Hansen - Afton MN, US

International Classification:

C08G 59/24
C08G 59/26
C08G 59/32
C08G 59/38
C08G 59/40
C08L 63/00
C08K 3/08
C09J 7/38

Abstract:

A curable composition comprises: 1 to 65 percent by weight of polyepoxide comprising an addition reaction product of phenolphthalein and bisphenol A diglycidyl ether; 5 to 50 percent by weight of liquid polyepoxide; and an effective amount of curative for curing the curable composition. A curable adhesive film comprising the curable composition, and method of bonding are also disclosed.

US Patent:

20180344631, Dec 6, 2018

Filed:

Aug 9, 2018

Appl. No.:

16/059522

Inventors:

- St. Paul MN, US
Kristen J. Hansen - Afton MN, US
Amy S. Determan - Mahtomedi MN, US

International Classification:

A61K 9/00
A61M 37/00

Abstract:

A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.