Kristen L Kozielski

US Patent:

20120114759, May 10, 2012

Filed:

Oct 12, 2011

Appl. No.:

13/272042

Inventors:

Jordan Jamieson Green - Nottingham MD, US
Aleksander S. Popel - Lutherville MD, US
Joel Chaim Sunshine - Pikesville MD, US
Ron B. Shmueli - Baltimore MD, US
Stephany Yi Tzeng - Baltimore MD, US
Kristen Lynn Kozielski - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 9/14
A61K 31/713
A61K 48/00
A61K 31/7105
A61K 31/711
A61K 47/34
A61P 35/00
A61K 38/10
A61K 38/08
A61K 38/20
A61K 38/39
C12N 5/071
C12N 15/85
A61P 27/02
C08G 75/00
C08L 5/00
A61K 38/02
B82Y 30/00

US Classification:

424491, 514 11, 514 44 A, 514 44 R, 5147723, 514 133, 514 192, 514 214, 514 216, 514 215, 514 217, 514 218, 424 852, 514 51, 424499, 435375, 435455, 528360, 524 56, 428402, 977773

Abstract:

Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.

US Patent:

20210220287, Jul 22, 2021

Filed:

Jan 14, 2021

Appl. No.:

17/149583

Inventors:

- Baltimore MD, US
Aleksander S. Popel - Lutherville MD, US
Joel Chaim Sunshine - Pikesville MD, US
Ron B. Shmueli - Baltimore MD, US
Stephany Yi Tzeng - Baltimroe MD, US
Kristen Lynn Kozielski - Baltimore MD, US

International Classification:

A61K 9/50
A61K 9/00
A61K 47/34
A61K 31/7105
C12N 15/88
A61K 9/19
A61K 31/711
A61K 31/713
B82Y 5/00
C12N 15/11
A61K 9/51
A61K 38/39
A61K 9/06

Abstract:

Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.

US Patent:

20190209690, Jul 11, 2019

Filed:

Oct 25, 2013

Appl. No.:

14/438353

Inventors:

- Baltimore MD, US
Kristen Kozielski - Baltimore MD, US
Stephany Yi Tzeng - Baltimore MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - BALTIMORE MD

International Classification:

A61K 47/32
A61K 31/713
C08F 222/24
C08F 222/14

Abstract:

Degradable polymers were synthesized that self-assemble with nucleic acids, proteins, hydrophobic drugs, and other small molecules to form particles that are effective for delivery into a cell, tissue and/or organism either in vitro or in vivo. The presently disclosed polymers demonstrate differential cell-type specificity, an ability to promote endosomal escape to protect the cargos from degradation and enhance delivery to the cytoplasm, and/or bioreducibility, which enables triggered intracellular drug release to be tuned to promote optimal delivery to the target cell type. The presently disclosed materials may be used to treat a wide variety of conditions or diseases, such as cancer, cardiovascular diseases, infectious diseases, and ophthalmic diseases.

US Patent:

20180028455, Feb 1, 2018

Filed:

Jul 10, 2017

Appl. No.:

15/645337

Inventors:

- Baltimore MD, US
Aleksander S. Popel - Lutherville MD, US
Joel Chaim Sunshine - Pikesville MD, US
Ron B. Shmueli - Baltimore MD, US
Stephany Yi Tzeng - Baltimore MD, US
Kristen Lynn Kozielski - Baltimore MD, US

International Classification:

A61K 9/50
C12N 15/88
B82Y 5/00
A61K 47/34
A61K 38/39
A61K 9/00
A61K 31/711
A61K 31/7105
A61K 9/51
A61K 9/19
A61K 9/06
C12N 15/11
A61K 31/713

Abstract:

Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.