Kristina A Finn

US Patent:

20100143464, Jun 10, 2010

Filed:

Dec 8, 2009

Appl. No.:

12/633270

Inventors:

Cherie Stabler - Coral Gables FL, US
Kristina Finn - Gainesville FL, US
Camillo Ricordi - Miami FL, US
Hernan R. Rengifo - Deerfield Beach FL, US

International Classification:

A61K 9/48
A61K 35/00
A61K 31/7088

US Classification:

424463, 424451, 424 931, 514 44 R

Abstract:

A biocompatible capsule comprising a biological material encapsulated by a covalently stabilized coating and a method of making the same are disclosed. The biological material can be a material selected from the group consisting of cells, such as islets of Langerhans, pharmaceuticals, and biological agents. The coating can be formed by reacting an alginate-[polyalkylene glycol (PAG)-X], and a multi-functional PAG-X, to form covalent bonds, wherein n is an integer greater than 0, a first one of Xand Xis N, and a second one of Xand Xis selected from the group consisting of:wherein R=CH, CHCH, CH(CH),