Kristine E Yoder

US Patent:

20050158724, Jul 21, 2005

Filed:

Apr 4, 2003

Appl. No.:

10/510363

Inventors:

Richard Fishel - Penn Valley PA, US
Kristine Yoder - Penn Valley PA, US

International Classification:

C12Q001/68
C12N015/867

US Classification:

435006000, 435456000

Abstract:

Retroviruses are RNA viruses that must insert a DNA copy (cDNA) of their genome into the host genome in order to carryout a productive infection. One host cellular pathway that defends against retroviral cDNA integration involves highly conserved proteins of a host DNA repair pathway. These proteins represent novel targets for anti-retroviral drugs. The invention presented herein provides, inter alia, methods of identifying compounds that induce a DNA repair pathway and/or inhibit retroviral cDNA integration into a host genome, compounds thus identified, uses of such compounds, and kits for identifying and testing of the efficacy of compounds in inducing a DNA repair pathway, inhibiting retroviral cDNA integration, and inhibiting retroviral infection.