Kristyn E Greco

US Patent:

20080138261, Jun 12, 2008

Filed:

Dec 7, 2006

Appl. No.:

11/635312

Inventors:

Robin H. Bogner - Hampton CT, US
Theodore L. Bergman - Storrs CT, US
Kristyn Greco - Mansfield Center CT, US
Derek J. Michaels - Windham NH, US
Szymon J. Chawarski - New Haven CT, US

International Classification:

B01D 11/02

US Classification:

422266, 422255

Abstract:

The present disclosure is directed to an apparatus and method for studying dissolution of a compact sample. The compact sample is typically a pharmaceutical drug sample. A flow-through apparatus includes a frame defining a flow-through channel, a removable insert having a drug sample, the insert positioned within the frame such that a fluid interacts with the sample when the fluid passes through the flow channel. The frame has an opening on the top side to allow a glass plate, typically a microscope cover slip to be positioned within the frame and allow viewing of the fluid flow and interaction with the drug sample. The hydrodynamics of the fluid flow are either known or computed. Thus, dissolution can be studied and observed in view of hydrodynamic characteristics. Typically, only a small amount of sample is necessary for a study. The flow-through apparatus is designed to fit on a microscopy stage and allow visual observation of the fluid/sample interaction.

US Patent:

20060040922, Feb 23, 2006

Filed:

Oct 18, 2005

Appl. No.:

11/252862

Inventors:

Kristyn Greco - N. Quincy MA, US
James Wright - Lexington MA, US

International Classification:

A61K 31/551
A61K 31/496
A61K 31/445

US Classification:

514220000, 514253010, 514317000

Abstract:

The invention relates to the discovery that pamoate salts of haloperidol and aripiprazole result in a good to superior long acting and/or extended release profile. Thus, in one aspect of the invention, the invention includes pamoate salts of haloperidol or aripiprazole. Preferably, the pamoate salt is characterized by a ratio of haloperidol to pamoate of 1:1 or 2:1. The pamoate salt can be crystalline, such as a needle or a dense crystal, such as described in the Figures. The invention further relates to methods of treating an individual in need thereof comprising administering a pharmaceutical composition comprising a pamoate salt of haloperidol and aripiprazole.