Kuldeep K Bhargava

US Patent:

48838624, Nov 28, 1989

Filed:

Apr 13, 1988

Appl. No.:

7/181227

Inventors:

Lakshman R. Chervu - Larchmont NY
Kuldeep K. Bhargava - Bronx NY
M. Donald Blaufox - Rye NY

Assignee:

Albert Einstein College of Medicine - of Yeshiva University - Bronx NY

International Classification:

H61K 3702
C07K 508

US Classification:

530331

Abstract:

The novel compound mercaptosuccinyl glycyl-glycyl-glycine (MSG. sub. 3) and a stable complex thereof with technetium-99m (Tc-99m) having utility as a renal agent. MSG. sub. 3 is made by coupling glycyl-glycyl-glycine with S-acetyl-mercapto succinic anhydride.

US Patent:

48836508, Nov 28, 1989

Filed:

Apr 13, 1988

Appl. No.:

7/181229

Inventors:

Kuldeep K. Bhargava - Bronx NY
Lakshman R. Chervu - Larchmont NY
M. Donald Blaufox - Rye NY

Assignee:

ALbert Einstein College of Medicine - of Yeshiva University - Bronx NY

International Classification:

A61K 4902
A61K 39395
C07D20746

US Classification:

424 11

Abstract:

The novel N-hydroxysuccinimide ester of iodohippuric acid (IH-OSU), capable of forming a stable conjugate with a protein. The iodohippuric acid is preferably orthoiodohippuric acid (OIH) and radiolabeled. A protein compound useful as a radiolable comprises a stable conjugate of a protein and the N-hydroxysuccinimide ester of radiolabeled iodohippuric acid.