Kurt Lawrence Berens

US Patent:

20020132220, Sep 19, 2002

Filed:

Dec 17, 2001

Appl. No.:

10/024081

Inventors:

Kurt Berens - Houston TX, US
Richard Dixon - Houston TX, US
Brian Dupre - Houston TX, US

International Classification:

A01N001/00
A01N001/02

US Classification:

435/001100

Abstract:

A method for protecting a mammalian organ, tissue or cell from damage during isolation from the circulatory system by contacting a mammalian organ, tissue or cell with a solution containing at least one selectin antagonist in an amount sufficient to inhibit selectin binding and/or cell signaling is disclosed. The selectin antagonist is a small molecule inhibitor of the selectin family of adhesion molecules. A composition for preservation or maintenance of a mammalian organ, tissue or cell containing such selectin antagonists is also disclosed. A presently preferred selectin antagonist is bimosiamose disodium.