Kurt H Stenzel

US Patent:

6780643, Aug 24, 2004

Filed:

Dec 12, 2000

Appl. No.:

09/735073

Inventors:

Shirin Asina - New York NY
Kanti Jain - New York NY
Albert L. Rubin - Englewood NJ
Barry Smith - New York NY
Kurt Stenzel - New York NY

Assignee:

The Rogosin Institute - New York NY

International Classification:

C12N 506

US Classification:

435382, 424 937, 424520, 435177, 435178, 435182, 435395

Abstract:

Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

US Patent:

6808705, Oct 26, 2004

Filed:

Jan 3, 2003

Appl. No.:

10/336379

Inventors:

Shirin Asina - New York NY
Kanti Jain - New York NY
Albert L. Rubin - Englewood NJ
Barry Smith - New York NY
Kurt Stenzel - New York NY

Assignee:

The Rogosin Institute - New York NY

International Classification:

A61K 3512

US Classification:

424 937, 424520, 435177, 435178, 435182, 435382, 435395

Abstract:

Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

US Patent:

6818230, Nov 16, 2004

Filed:

Jan 3, 2003

Appl. No.:

10/336313

Inventors:

Shirin Asina - New York NY
Kanti Jain - New York NY
Albert L. Rubin - Englewood NJ
Barry Smith - New York NY
Kurt Stenzel - New York NY

Assignee:

The Rogosin Institute - New York NY

International Classification:

A61K 3512

US Classification:

424520, 424 937, 435177, 435178, 435182, 435382, 435395

Abstract:

Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

US Patent:

7041504, May 9, 2006

Filed:

Dec 12, 2000

Appl. No.:

09/735073

Inventors:

Shirin Asina - New York NY, US
Kanti Jain - New York NY, US
Albert L. Rubin - Englewood NJ, US
Barry Smith - New York NY, US
Kurt Stenzel - New York NY, US

Assignee:

The Rogosin Institute - New York NY

International Classification:

C12N 5/06
C12N 5/08
C12N 11/10
C12N 11/04
A61K 35/12

US Classification:

435382, 424 937, 424520, 435177, 435178, 435182, 435395

Abstract:

Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

US Patent:

7297331, Nov 20, 2007

Filed:

Aug 16, 2004

Appl. No.:

10/919767

Inventors:

Shirin Asina - New York NY, US
Kanti Jain - New York NY, US
Albert L. Rubin - Englewood NJ, US
Barry Smith - New York NY, US
Kurt Stenzel - New York NY, US

Assignee:

The Rogosin Institute - New York NY

International Classification:

A61K 35/12
C12N 11/02
C12N 11/10
C12N 5/00
C12N 5/08

US Classification:

424 937, 435177, 435178, 435182, 435366, 435382, 435395, 435397

Abstract:

Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

US Patent:

7838291, Nov 23, 2010

Filed:

Aug 10, 2007

Appl. No.:

11/891526

Inventors:

Bryan Conn - New York NY, US
Barry Smith - New York NY, US
Albert L. Rubin - Engelwood NJ, US
Kurt Stenzel - New York NY, US

Assignee:

The Rogosin Institute - New York NY

International Classification:

C12N 5/00
C12N 5/02

US Classification:

435374, 435375, 435377, 435382, 435395

Abstract:

The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

US Patent:

20050053586, Mar 10, 2005

Filed:

Sep 4, 2003

Appl. No.:

10/655275

Inventors:

Bryan Conn - New York NY, US
Barry Smith - New York NY, US
Albert Rubin - Engelwood NJ, US
Kurt Stenzel - New York NY, US

International Classification:

A61K048/00
C12N005/08

US Classification:

424093700, 435366000

Abstract:

The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

US Patent:

20060216278, Sep 28, 2006

Filed:

Jun 5, 2006

Appl. No.:

11/447405

Inventors:

Bryan Conn - New York NY, US
Barry Smith - New York NY, US
Albert Rubin - Engelwood NJ, US
Kurt Stenzel - New York NY, US

International Classification:

A61K 48/00
C12N 5/08

US Classification:

424093210, 435366000

Abstract:

The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.