Kyle J Robinson

US Patent:

20030158218, Aug 21, 2003

Filed:

Dec 6, 2002

Appl. No.:

10/313533

Inventors:

Philippe Nantermet - Lansdale PA, US
Harold Selnick - Ambler PA, US
James Barrow - Harleysville PA, US
Craig Coburn - Royersford PA, US
Christopher Burgey - Philadelphia PA, US
Kyle Robinson - Philadelphia PA, US
Terry Lyle - Lederach PA, US

International Classification:

A61K031/506
A61K031/4745
A61K031/444
C07D471/02
C 07D 4 1/02
C 07D 4 3/02

US Classification:

514/275000, 514/300000, 514/332000, 514/352000, 544/331000, 546/122000, 546/264000, 546/312000

Abstract:

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: wherein Ris, for example, hydrogen, Cl, or cyano, and Ris, for example, hydrogen,

US Patent:

20060024330, Feb 2, 2006

Filed:

Sep 10, 2003

Appl. No.:

10/526275

Inventors:

John Wai - Harleysville PA, US
Boyoung Kim - Lansdale PA, US
Thorsten Fisher - Hatfield PA, US
Linghang Zhuang - Chalfont PA, US
Peter Williams - Harleysville PA, US
Terry Lyle - Lederach PA, US
H. Langford - Lansdale PA, US
Kyle Robinson - Philadelphia PA, US

International Classification:

A61P 31/18
A61K 39/21
C07D 471/00
C07D 487/00

US Classification:

424208100, 544350000, 544349000, 544336000

Abstract:

8,9-Dihydroxydihydropyridopyrazine-1,6-diones and 8,9-dihydroxypyridopyrazine-1,6-diones are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the pyridopyrazinediones are of Formula (I): (I), wherein R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.