Larry John Braga

US Patent:

55501877, Aug 27, 1996

Filed:

Aug 8, 1994

Appl. No.:

8/287549

Inventors:

Woonza M. Rhee - Palo Alto CA
Richard A. Berg - Los Altos CA
Joel S. Rosenblatt - Palo Alto CA
Jacqueline A. Tefft - Redwood City CA
Larry J. Braga - Fremont CA
Thomas L. Smestad - Palo Alto CA

Assignee:

Collagen Corporation - Palo Alto CA

International Classification:

C08G 6349
C08G 6391

US Classification:

525 541

Abstract:

The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention are also disclosed.

US Patent:

56434642, Jul 1, 1997

Filed:

Jun 30, 1995

Appl. No.:

8/497573

Inventors:

Woonza M. Rhee - Palo Alto CA
Richard A. Berg - Los Altos CA
Joel S. Rosenblatt - Palo Alto CA
Jacqueline A. Schroeder - Redwood City CA
Larry J. Braga - Fremont CA
Thomas L. Smestad - Palo Alto CA
Abigail Freeman - Fremont CA

Assignee:

Collagen Corporation - Palo Alto CA

International Classification:

B01J 1908
A01N 102
A61F 200

US Classification:

210748

Abstract:

The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention are also disclosed.

US Patent:

55278566, Jun 18, 1996

Filed:

May 12, 1995

Appl. No.:

8/440274

Inventors:

Woonza M. Rhee - Palo Alto CA
Richard A. Berg - Los Altos CA
Joel S. Rosenblatt - Palo Alto CA
Jacqueline A. Tefft - Redwood City CA
Larry J. Braga - Fremont CA
Thomas L. Smestad - Palo Alto CA

Assignee:

Collagen Corporation - Palo Alto CA

International Classification:

C08G 6348
C08G 6391

US Classification:

525 541

Abstract:

The present invention discloses a novel method for preparing crosslinked biomaterial compositions for use in the augmentation of soft or hard tissue. In general, the method comprises mixing a biocompatible polymer, which is preferably collagen, with a sterile, dry crosslinking agent, which is preferably a synthetic hydrophilic polymer such as a functionally activated polyethylene glycol. Also provided are preferred processes for preparing sterile, dry crosslinking agents contained within syringes for use in the method of the invention. Methods for sterilization of the crosslinking agent include, but are not limited to, sterile filtration, aseptic processing, and e-beam or gamma irradiation. Methods for providing augmentation of soft or hard tissue using crosslinked biomaterial compositions prepared according to the method of the invention am also disclosed.