Larry A Couture

US Patent:

7318919, Jan 15, 2008

Filed:

Jun 3, 2002

Appl. No.:

10/161539

Inventors:

Richard Gregory - Westford MA, US
Donna Armentano - Belmont MA, US
Larry A. Couture - Louisville CO, US
Alan E. Smith - Dover MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 48/00
C12N 15/861

US Classification:

424 932, 4353201, 435455, 435456

Abstract:

Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.

US Patent:

20020164782, Nov 7, 2002

Filed:

May 11, 2000

Appl. No.:

09/568756

Inventors:

Richard Gregory - Westford MA, US
Donna Armentano - Belmont MA, US
Larry Couture - Louisville CO, US
Alan Smith - Dover MA, US

International Classification:

A61K048/00
C12N015/74
C12N005/06

US Classification:

435/320100, 435/325000, 424/093200

Abstract:

Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.

US Patent:

60935677, Jul 25, 2000

Filed:

Feb 10, 1999

Appl. No.:

9/248026

Inventors:

Richard J. Gregory - Westford MA
Donna Armentano - Belmont MA
Larry A. Couture - Louisville CO
Alan E. Smith - Dover MA

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 4800

US Classification:

4353201

Abstract:

Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.

US Patent:

58828770, Mar 16, 1999

Filed:

Jul 16, 1997

Appl. No.:

8/895194

Inventors:

Richard J. Gregory - Westford MA
Donna Armentano - Belmont MA
Larry A. Couture - Louisville CO
Alan E. Smith - Dover MA

Assignee:

Genzyme Corporation - Framingham MA

International Classification:

C12N 1500
C12N 1586

US Classification:

4353201

Abstract:

Adenoviral vectors which contain deletions of the early regions and/or late genes provide efficient delivery and expression of foreign nucleic acids of interest to patients. These vectors have a particular use in the treatment of cystic fibrosis patients. Furthermore, PAV vectors provide for a second generation of adenoviral vectors that contain the 5' ITR's, the packaging signal and the E1A enhancer. Other adenoviral vectors contain a deletion of the E1 region or a deletion of E4 but retain orf3 or orf6, and can either retain or delete the E3 region.

US Patent:

56704887, Sep 23, 1997

Filed:

Oct 13, 1993

Appl. No.:

8/136742

Inventors:

Richard J. Gregory - Carlsbad CA
Donna Armentano - Watertown MA
Larry A. Couture - Framingham MA
Alan E. Smith - Wellesley MA

Assignee:

Genzyme Corporation - Framingham MA

International Classification:

A61K 4800
C12N 1500

US Classification:

514 44

Abstract:

Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed.

US Patent:

57053880, Jan 6, 1998

Filed:

Dec 23, 1994

Appl. No.:

8/363240

Inventors:

Larry Couture - Louisville CO
Dan Stinchcomb - Boulder CO
James McSwiggen - Boulder CO
Charles Bisgaier - Ann Arbor MI
Michael Pape - Ann Arbor MI

Assignee:

Ribozyme Pharmaceuticals, Inc. - Boulder CO
Warner-Lambert Company - Ann Arbor MI

International Classification:

C12N 1585
C12Q 168

US Classification:

435366

Abstract:

A nucleic acid molecule which blocks synthesis and/or expression of mRNAs associated with initial development, progression or regression of vascular disease.

US Patent:

20220228122, Jul 21, 2022

Filed:

Jan 28, 2022

Appl. No.:

17/587911

Inventors:

- Galway, IE
Jack KAVANAUGH - Los Angeles CA, US
Larry A. COUTURE - Claremont CA, US
Lisa O'FLYNN - Galway, IE

International Classification:

C12N 5/0775
A61P 25/28
A61P 1/16
A61P 37/06
A61P 19/02
A61P 13/12
A61P 17/02
A61P 11/00
A61P 29/00
A61K 9/00
A61K 9/06
A61K 35/35
G01N 33/543

Abstract:

Disclosed herein are methods of isolating SDC2+ stromal stem cells and exosomes from SDC2+ stromal stem cells by expression of surface marker CD39. Also disclosed herein are stromal stem cells and exosomes isolated by said methods.

US Patent:

20190015331, Jan 17, 2019

Filed:

Jan 13, 2017

Appl. No.:

16/070202

Inventors:

- galway, IE
Jack Kavanaugh - Los Angeles CA, US
Larry COUTURE - Claremont CA, US

International Classification:

A61K 9/127
A61P 29/00
A61P 3/00
A61K 38/17
A61K 35/12

Abstract:

Disclosed herein are compositions comprising isolated exosomes, for instance exosomes wherein at least 20% of the exosomes comprise SDC2, methods of isolation, and methods of use.