Larry E Morrison

US Patent:

5219734, Jun 15, 1993

Filed:

Jan 13, 1988

Appl. No.:

7/143586

Inventors:

Garfield P. Royer - Elburn IL
Larry E. Morrison - Glen Ellyn IL
Kenneth A. Cruickshank - Naperville IL

Assignee:

Amoco Corporation - Chicago IL

International Classification:

C12Q 168
C07H 1512
C07H 1700
C12N 1500

US Classification:

435 6

Abstract:

Methods, apparatus and compositions are presented for ligating ligands together which bind to a common target. One embodiment includes polynucleotide probes having photoreactive functional groups. The probes are capable of assuming substantially contiguous reactive positions on a target polynucleotide placing the photoreactive groups in juxtaposition. Activation of the photoreactive functional groups with radiant energy form a probe reaction product in which the probes are bound to each other.

US Patent:

7517645, Apr 14, 2009

Filed:

Jun 2, 2004

Appl. No.:

10/857859

Inventors:

Irina A. Sokolova - Villa Park IL, US
Steven A. Seelig - Elmhurst IL, US
Larry E. Morrison - Glen Ellyn IL, US
Walter King - Wheaton IL, US

Assignee:

VYSIS, Inc. - Downers Grove IL

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/02
C07H 21/04

US Classification:

435 6, 435 912, 536 231, 536 243

Abstract:

Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.

US Patent:

7998678, Aug 16, 2011

Filed:

Aug 6, 2009

Appl. No.:

12/536647

Inventors:

Larry E. Morrison - Glen Ellyn IL, US
Irina A. Sokolova - Villa Park IL, US
Steven A. Seelig - Elmhurst IL, US
Kevin C. Halling - Rochester MN, US

Assignee:

VYSIS, Inc. - Downers Grove IL
Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

C12Q 1/68
C07H 21/02
C07H 21/04

US Classification:

435 6, 536 231, 536 2431

Abstract:

Probe sets and methods of using probes and probe sets for the detection of cancer are described. Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if cancer cells are present the sample. Also included are methods of selecting a combination of probes for the detection of cancer.

US Patent:

8034577, Oct 11, 2011

Filed:

Feb 17, 2006

Appl. No.:

11/356786

Inventors:

Kevin Halling - Rochester MN, US
Larry E. Morrison - Glen Ellyn IL, US
Shannon Brankley - Rochester MN, US

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN
Abbott Laboratories, Inc. - Des Plaines IL

International Classification:

G01N 33/53

US Classification:

435 723, 536 243

Abstract:

Probe sets and methods of using probes and probe sets for selectively detecting high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia from biologic samples are described. Methods of the invention include contacting a biological sample obtained from a subject with a set of chromosomal probes to selectively detect an esophageal carcinoma or precursor lesion in the sample, if any, under conditions for specifically hybridizing the probes to their nucleic targets present in the sample. The presence or absence of high grade dysplasia and esophageal adenocarcinoma or low grade dysplasia is thereafter specifically determined from the hybridization pattern detected for the set of chromosomal probes to the biological sample.

US Patent:

8105768, Jan 31, 2012

Filed:

Mar 8, 2006

Appl. No.:

11/371294

Inventors:

Larry E. Morrison - Glen Ellyn IL, US
Susan Jewell - Gurnee IL, US
John S. Coon - Oak Park IL, US

Assignee:

Abbott Laboratories - Abbott Park IL
Rush University Medical Center - Chicago IL

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention provides methods for identifying cancer patients susceptible to effective treatment with trastuzumab and other medications that function similarly to trastuzumab. The invention is based on the discovery that certain chromosomal abnormalities can be used to selectively identify cancer patients that are likely to be successfully treated with medication that inhibits the signaling capability of the HER-2 receptor protein or otherwise function similarly to trastuzumab. The invention is based on the use of nucleic acid technology where nucleic acid probes are allowed to hybridize to cell samples and the number of copies of particular genetic regions quantified. The present invention also provides kits and sets of probes for use in identifying cancer patients susceptible to effective treatment with trastuzumab and other medications that function similarly to trastuzumab.

US Patent:

8309302, Nov 13, 2012

Filed:

Jul 13, 2006

Appl. No.:

11/485901

Inventors:

Robert W. Jaekel - Deer Park IL, US
Anna O'hare - Downers Grove IL, US
Larry E. Morrison - Glen Ellyn IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12Q 1/68
G01N 1/30
C07H 21/04
C07K 5/00

US Classification:

435 61, 435 72, 435 405, 435325, 536 231, 530300

Abstract:

Methods and processing reagents for improving washing and aging a biological sample in an assay are disclosed. The processing reagents comprise an aqueous base reagent and a low vapor pressure composition in sufficient amount to raise the boiling point of the base reagent. The methods comprise applying the base reagent and low vapor pressure composition to the biological sample for use at an elevated temperature.

US Patent:

8043805, Oct 25, 2011

Filed:

Apr 13, 2009

Appl. No.:

12/422859

Inventors:

Irina A. Sokolova - Villa Park IL, US
Steven A. Seelig - Elmhurst IL, US
Larry E. Morrison - Glen Ellyn IL, US
Walter King - Wheaton IL, US

Assignee:

Vysis, Inc. - Downers Grove IL

International Classification:

C12Q 1/68
C12P 19/34
C12M 1/34
C07H 21/02
C07H 21/04

US Classification:

435 6, 435 912, 4352871, 536 231, 536 243

Abstract:

Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated with a risk for cancer, and preferably involves screening for HPV infected cells by in situ hybridization using an HPV probe mixture.

US Patent:

20020025523, Feb 28, 2002

Filed:

Jun 21, 2001

Appl. No.:

09/795953

Inventors:

Michael Bittner - Naperville IL, US
Larry Morrison - Glen Ellyn IL, US
Mona Legator - Chicago IL, US

International Classification:

C12Q001/68
C07H021/04

US Classification:

435/006000, 536/024300

Abstract:

Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.