Laura T Bald

US Patent:

6927061, Aug 9, 2005

Filed:

May 23, 2003

Appl. No.:

10/445179

Inventors:

Laura Bald - Los Altos CA, US
Jennie Powell Mather - Millbrae CA, US

Assignee:

Raven Biotechnologies, Inc. - South San Francisco CA

International Classification:

C12N005/00

US Classification:

435366, 435325, 435378

Abstract:

The invention discloses a substantially pure population of human ovarian mesothelial cells and methods of isolating and culturing the ovarian mesothelial cells. By carefully manipulating the microenvironment of the ovarian mesothelial cells, multiple passages are attainable wherein the ovarian mesothelial cells are capable of becoming ovary surface epithelial cells or granulosa cells. In addition, several methods of use of human ovarian mesothelial cells are disclosed herein.

US Patent:

6987024, Jan 17, 2006

Filed:

Apr 10, 2000

Appl. No.:

09/545659

Inventors:

Laura Bald - Los Altos CA, US
Jennie Powell Mather - Millbrae CA, US

Assignee:

Raven Biotechnologies, Inc. - South San Francisco CA

International Classification:

C12N 5/00

US Classification:

435366, 435325

Abstract:

The invention discloses a substantially pure population of human ovarian mesothelial cells and methods of isolating and culturing the ovarian mesothelial cells. By carefully manipulating the microenvironment of the ovarian mesothelial cells, multiple passages are attainable wherein the ovarian mesothelial cells are capable of becoming ovary surface epithelial cells or granulosa cells. In addition, several methods of use of human ovarian mesothelial cells are disclosed herein.

US Patent:

20040137614, Jul 15, 2004

Filed:

Dec 22, 2003

Appl. No.:

10/744508

Inventors:

Laura Bald - Los Altos CA, US
Jennie Mather - Millbrae CA, US

International Classification:

G01N033/574
C12N005/08

US Classification:

435/366000, 435/007230

Abstract:

The invention discloses a substantially pure population of human ovarian mesothelial cells and methods of isolating and culturing the ovarian mesothelial cells. By carefully manipulating the microenvironment of the ovarian mesothelial cells, multiple passages are attainable wherein the ovarian mesothelial cells are capable of becoming ovary surface epithelial cells or granulosa cells. In addition, several methods of use of human ovarian mesothelial cells are disclosed herein.

US Patent:

20040146990, Jul 29, 2004

Filed:

Sep 26, 2003

Appl. No.:

10/672878

Inventors:

Jennie Mather - Millbrae CA, US
Laura Bald - Los Altos CA, US
Penelope Roberts - Millbrae CA, US
Jean-Philippe Stephan - Millbrae CA, US

International Classification:

A61K039/395
C12P021/04
C07K016/22

US Classification:

435/070210, 530/388250

Abstract:

The present invention provides a method for generating a population of monoclonal antibodies capable of binding to antigens representative of a particular cell type. The method is unique in that it minimizes the generation of non-representative antibodies cross-reacting with proteins not present in a particular cell type; it also maximizes the preservation of intact antigens, especially surface antigens, for production of a plurality of monoclonal antibodies that bind to the native antigens. The present invention also includes a method of determining the combination of cell surface antigens present on a specific cell type. Further provided by the invention are hybridomas, populations of monoclonal antibodies produced by the hybridomas of the present invention.