Laura J Hays

US Patent:

20090305266, Dec 10, 2009

Filed:

May 2, 2007

Appl. No.:

12/299233

Inventors:

Grover C. Bagby - Portland OR, US
Tanja Pejovic - Portland OR, US
Laura Hays - Portland OR, US
Susan Olson - Portland OR, US

International Classification:

C12Q 1/68
C12Q 1/02
C40B 30/04
G01N 33/574

US Classification:

435 6, 435 29, 506 9, 435 723

Abstract:

Methods are provided for determining diagnosing ovarian and breast cancer in a subject, including diagnosing the predisposition of a subject's risk of developing breast or ovarian cancer. The methods include selecting a subject, for example a subject with one or more risk factors for developing ovarian cancer or breast cancer, and detecting a decrease in the activity of the Fanconi anemia (FA) non-nuclear core (NNC) component in the subject. Such a decrease is indicative of a predisposition to ovarian cancer and/or breast cancer in the subject. These methods can be used to monitor the response of a subject to agents designed to prevent breast and ovarian cancer, for example an anti-neoplastic agent. Methods also are provided for identifying agents of use in preventing breast and ovarian cancer.