Arthur G. Taveras - Denville NJ, US Cynthia J. Aki - Livingston NJ, US Richard W. Bond - Union NJ, US Jianping Chao - Summit NJ, US Michael Dwyer - Scotch Plains NJ, US Johan A. Ferreira - Bensalem PA, US Jianhua Chao - Pompton Lakes NJ, US Younong Yu - Piscataway NJ, US John J. Baldwin - Gwynedd Valley PA, US Bernd Kaiser - Walingford CT, US Ge Li - Shanghai, CN J. Robert Merritt - Ewing NJ, US Purakkattle J. Biju - Scotch Plains NJ, US Laura L. Rokosz - Union NJ, US Gaifa Lai - Edison NJ, US
Arthur Taveras - Denville NJ, US Cynthia Aki - Livingston NJ, US Richard Bond - Union NJ, US Jianping Chao - Summit NJ, US Michael Dwyer - Scotch Plains NJ, US Johan Ferreira - Bensalem PA, US Jonathan Pachter - Maplewood NJ, US John Baldwin - Gwynedd Valley PA, US Bernd Kaiser - Plainsboro NJ, US Ge Li - ShangHai, CN J. Merritt - Ewing NJ, US Kingsley Nelson - Mebane NC, US Laura Rokosz - Union NJ, US
Assignee:
Schering Corporation
International Classification:
C07D417/02 C07D413/02
US Classification:
548/152000, 548/217000, 548/465000, 564/306000
Abstract:
There are disclosed compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or isomer of said compound or of said prodrug, which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
3, 4-Di-Substituted Cyclobutene-1,2-Diones As Cxc-Chemokine Receptor Antagonists
Arthur Taveras - Denville NJ, US Cynthia Aki - Livingston NJ, US Richard Bond - Union NJ, US Jianping Chao - Summit NJ, US Michael Dwyer - Scotch Plains NJ, US Johan Ferreira - Bethlehem PA, US Jonathan Pachter - Maplewood NJ, US John Baldwin - Gwynedd Valley PA, US Bernd Kaiser - Wallingford CT, US Ge Li - Shanghai, CN J. Merritt - Ewing NJ, US Kingsley Nelson - Mebane NC, US Laura Rokosz - Union NJ, US
Disclosed are compounds of the formula: or a pharmaceutically acceptable salt or solvate thereof. Also disclosed are the use of compounds of formula I for the treatment of chemokine-mediated diseases such as cancer, and acute and chronic inflammatory disorders.
3,4-Di-Substituted Cyclobutene-1,2-Diones As Cxc-Chemokine Receptor Ligands
Arthur Taveras - Denville NJ, US Cynthia Aki - Livingston NJ, US Richard Bond - Union NJ, US Jianping Chao - Summit NJ, US Michael Dwyer - Scotch Plains NJ, US Johan Ferreira - Bethlehem PA, US Jianhua Chao - Wayne NJ, US Younong Yu - Piscataway NJ, US John Baldwin - Gwynedd Valley PA, US Bernd Kaiser - Wallingford NJ, US Ge Li - Shanghai, CN J. Merritt - Ewing NJ, US Kingsley Nelson - Mebane NC, US Laura Rokosz - Union NJ, US
There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
3,4-Di-Substituted Cyclobutene-1,2-Diones As Cxc-Chemokine Receptor Ligands
Arthur Taveras - Denville NJ, US Cynthia Aki - Livingston NJ, US Richard Bond - Union NJ, US Jianping Chao - Summit NJ, US Michael Dwyer - Scotch Plains NJ, US Johan Ferreira - Bethlehem PA, US Jianhua Chao - Pompton Lakes NJ, US Younong Yu - Piscataway NJ, US John Baldwin - Gwynedd Valley PA, US Bernd Kaiser - Walling Ford CT, US Ge Li - Shanghai, CN J. Merritt - Ewing NJ, US Purakkattle Biju - Scotch Plains NJ, US Kingsley Nelson - Mebane NC, US Laura Rokosz - Union NJ, US
Assignee:
Schering Corporation
International Classification:
C07D333/36 C07D333/42 C07D265/30 C 07D 4 3/02 C07D413/02 C 07D 4 5/02 C 07D 4 9/02
There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
3,4-Di-Substituted Cyclobutene-1,2-Diones As Cxc-Chemokine Receptor Ligands
Arthur Taveras - Denville NJ, US Cynthia Aki - Livingston NJ, US Richard Bond - Union NJ, US Jianping Chao - Summit NJ, US Michael Dwyer - Scotch Plains NJ, US Johan Ferreira - Bethlehem PA, US Jianhua Chao - Pompton Lakes NJ, US Younong Yu - Scotch Plains NJ, US John Baldwin - Gwynedd Valley PA, US Bernd Kaiser - Wallingford CT, US Ge Li - Shanghai, CN J. Merritt - Ewing NJ, US Purakkattle Biju - Scotch Plains NJ, US Kingsley Nelson - Mebane NC, US Laura Rokosz - Union NJ, US James Jakway - Bridgewater NJ, US Gaifa Lai - Edison NJ, US Minglang Wu - Monmouth Junction NJ, US Evan Hecker - Austin TX, US Daniel Lundell - Flemington NJ, US Jay Fine - Bloomfield NJ, US
There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
3,4-Di-Substituted Cyclobutene-1,2-Diones As Cxc-Chemokine Receptor Antagonists
Arthur Taveras - Denville NJ, US Cynthia Aki - Livingston NJ, US Richard Bond - Union NJ, US Jianping Chao - Summit NJ, US Michael Dwyer - Scotch Plains NJ, US Johan Ferreira - Bethlehem PA, US Jonathan Pachter - Maplewood NJ, US John Baldwin - Gwynedd Valley PA, US Bernd Kaiser - Wallingford CT, US Ge Li - Shanghai, CN J. Merritt - Ewing NJ, US Kingsley Nelson - Mebane NC, US Laura Rokosz - Union NJ, US
Disclosed are compounds of the formula: or a pharmaceutically acceptable salt or solvate thereof. Also disclosed are the use of compounds of formula I for the treatment of chemokine-mediated diseases such as cancer, and acute and chronic inflammatory disorders.
3,4-Di-Substituted Cyclobutene-1,2-Diones As Cxc-Chemokine Receptor Ligands
Arthur G. Taveras - Denville NJ, US Cynthia J. Aki - Livingston NJ, US Richard W. Bond - Union NJ, US Jianping Chao - Summit NJ, US Michael Dwyer - Scotch Plains NJ, US Johan A. Ferreira - Bensalem PA, US Jianhua Chao - Pompton Lakes NJ, US Younong Yu - Piscataway NJ, US John J. Baldwin - Gwynedd Valley PA, US Bernd Kaiser - Wallingford CT, US Ge Li - Shanghai, CN J. Robert Merritt - Ewing NJ, US Purakkattle J. Biju - Scotch Plains NJ, US Laura L. Rokosz - Union NJ, US Gaifa Lai - Edison NJ, US James P. Jakway - Bridgewater NJ, US Minglang Wu - Monmouth Junction NJ, US Evan A. Hecker - Austin TX, US Daniel Lundell - Flemington NJ, US Jay S. Fine - Bloomfield NJ, US
There are disclosed compounds of the formulaor a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
Belmar Womens Care 3222 S Vance St STE 200, Denver, CO 80227 3035314660 (phone), 3035314659 (fax)
Goodland Regional Medical Center Outpatient Clinic 220 W 2 St, Goodland, KS 67735 7858903625 (phone), 7858906046 (fax)
Education:
Medical School Wayne State University School of Medicine Graduated: 1990
Procedures:
Hysterectomy Tubal Surgery Urinary Flow Tests Vaccine Administration Vaginal Repair
Conditions:
Candidiasis of Vulva and Vagina Endometriosis Genital HPV Menopausal and Postmenopausal Disorders Polycystic Ovarian Syndrome (PCOS)
Languages:
English
Description:
Dr. Rokosz graduated from the Wayne State University School of Medicine in 1990. She works in Goodland, KS and 1 other location and specializes in Gynecology. Dr. Rokosz is affiliated with Goodland Regional Medical Center, Porter Adventist Hospital and Swedish Medical Center.
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