Laura E Lin

US Patent:

6957150, Oct 18, 2005

Filed:

Jan 25, 2001

Appl. No.:

09/771383

Inventors:

Kevin Delos Parris - Auburndale MA, US
William Stuart Somers - Cambridge MA, US
Amy Szepui Tam - Medford MA, US
Laura Long Lin - Weston MA, US
Mark Lloyd Stahl - Lexington MA, US

Assignee:

Wyeth - Madison NJ
Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G06F019/00
G01N033/48
G01N031/00

US Classification:

702 27, 702 19, 702 22

Abstract:

This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.

US Patent:

7135319, Nov 14, 2006

Filed:

Nov 19, 2003

Appl. No.:

10/717138

Inventors:

Kevin Delos Parris - Auburndale MA, US
William Stuart Somers - Cambridge MA, US
Amy Szepui Tam - Medford MA, US
Laura Long Lin - Weston MA, US
Mark Lloyd Stahl - Lexington MA, US

Assignee:

Wyeth - Madison NJ

International Classification:

C12N 9/10

US Classification:

435193, 530300, 530344

Abstract:

This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

US Patent:

7584087, Sep 1, 2009

Filed:

Apr 6, 2005

Appl. No.:

11/099958

Inventors:

Zhang Bao Xu - Tewksbury MA, US
Stephane Olland - Arlington MA, US
Scott Wolfrom - Somerville MA, US
Karl Malakian - Boxborough MA, US
Laura Lin - Weston MA, US
Mark Stahl - Lexington MA, US
Julie Lee - Somerville MA, US
Lori Fitz - Somerville MA, US
Rita Greco - Charlestown MA, US
Divya Chaudhary - Andover MA, US
William Stuart Somers - Lexington MA, US
Lidia Mosyak - Newton MA, US

Assignee:

Wyeth - Madison NJ

International Classification:

G06G 7/58
G01N 31/00
G01N 33/573
G01N 33/53
C12Q 1/00
C12Q 1/48
C12N 9/99
C12N 9/12

US Classification:

703 11, 702 27, 435 4, 435 74, 435 771, 435 15, 435184, 435194

Abstract:

A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.

US Patent:

7615213, Nov 10, 2009

Filed:

Jun 9, 2005

Appl. No.:

11/149309

Inventors:

Marion T. Kasaian - Charlestown MA, US
Lioudmila Tchistiakova - Andover MA, US
Geertruida M. Veldman - Sudbury MA, US
Kimberly Ann Marquette - Somerville MA, US
Xiang-Yang Tan - Reading MA, US
Debra D. Donaldson - Medford MA, US
Laura Long Lin - Weston MA, US
Tania Shane - Newton MA, US
Amy Sze Pui Tam - Medford MA, US
Eric Feyfant - Lexington MA, US
Nancy L. Wood - Somerville MA, US
Lori J. Fitz - Somerville MA, US
Angela M. Widom - Acton MA, US
Kevin D. Parris - Auburndale MA, US
Samuel J. Goldman - Acton MA, US
Jose W. Saldanha - Middlesex, GB

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 39/395

US Classification:

4241331, 4241451, 5303873, 53038823

Abstract:

This application relates to antibodies, e. g. , humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e. g. , a human patient, one or more IL-13-associated disorders, e. g. , respiratory disorders (e. g. , asthma); atopic disorders (e. g. , allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e. g. , atopic dermatitis), and gastrointestinal organs (e. g. , inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.

US Patent:

8221752, Jul 17, 2012

Filed:

Oct 8, 2009

Appl. No.:

12/575896

Inventors:

Marion T. Kasaian - Cambridge MA, US
Lioudmila Gennadievna Tchistiakova - Andover MA, US
Geertruida Machteld Veldman - Sudbury MA, US
Kimberly Ann Marquette - Somerville MA, US
Xiang-Yang Tan - Reading MA, US
Debra D. Donaldson - Medford MA, US
Laura Long Lin - Weston MA, US
Tania Shane - Newton MA, US
Amy Sze Pui Tam - Medford MA, US
Eric Feyfant - Lexington MA, US
Nancy L. Wood - Somerville MA, US
Lori J. Fitz - Somerville MA, US
Angela M. Widom - Acton MA, US
Kevin D. Parris - Auburndale MA, US
Samuel J. Goldman - Acton MA, US
Jose W. Saldanha - Enfield, GB

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 39/395

US Classification:

4241331, 4241581

Abstract:

This application relates to antibodies, e. g. , humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e. g. , a human patient, one or more IL-13-associated disorders, e. g. , respiratory disorders (e. g. , asthma); atopic disorders (e. g. , allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e. g. , atopic dermatitis), and gastrointestinal organs (e. g. , inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.

US Patent:

20030211588, Nov 13, 2003

Filed:

Jan 25, 2001

Appl. No.:

09/770834

Inventors:

Kevin Parris - Auburndale MA, US
William Somers - Cambridge MA, US
Amy Tam - Medford MA, US
Laura Lin - Weston MA, US
Mark Stahl - Lexington MA, US
Robert Powers - Westford MA, US

International Classification:

C12N009/10
G06F019/00
G01N033/48
G01N033/50
G01N031/00

US Classification:

435/193000, 702/019000

Abstract:

This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

US Patent:

20040091908, May 13, 2004

Filed:

Jul 1, 2003

Appl. No.:

10/611718

Inventors:

Weixin Xu - Acton MA, US
Laura Lin - Weston MA, US
Stephane Olland - Arlington MA, US
Lidia Mosyak - Newton MA, US
William Somers - Lexington MA, US

International Classification:

C12Q001/68
G01N033/53
G06F019/00
G01N033/48
G01N033/50
C07K014/705

US Classification:

435/006000, 435/007100, 530/350000, 702/019000

Abstract:

This invention is directed to the crystal structures of Kv channel proteins, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of Kv channel proteins. Such agents may be useful as therapeutic agents.

US Patent:

20070048785, Mar 1, 2007

Filed:

Jun 9, 2005

Appl. No.:

11/149025

Inventors:

Laura Lin - Weston MA, US
Kevin Parris - Auburndale MA, US
Amy Sze Tam - Medford MA, US
Xiang-Yang Tan - Reading MA, US
Tania Shane - Newton MA, US
John Dumas - Arlington MA, US
James Wilhelm - Boston MA, US
Mark Stahl - Lexington MA, US
Lidia Mosyak - Newton MA, US
Zhixiang Hu - Spring TX, US

International Classification:

C07K 16/28
G01N 33/53
G06F 19/00

US Classification:

435007100, 530388220, 702019000

Abstract:

Anti-IL-13 antibodies, crystals of anti-IL-13 antibodies, IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13 polypeptide/anti-IL-13 antibody complexes, IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, and related methods and software systems are disclosed.