Laura Lin

age ~33

from Salem, MA

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Laura Lin Phones & Addresses

320 Lafayette St APT 408, Salem, MA 01970

Us Patents

Methods For Identifying An Agent That Interacts With An Active Site Of Acyl Carrier Protein Synthase Or Acyl Carrier Protein Synthase Complex
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US Patent:

6957150, Oct 18, 2005
Filed:

Jan 25, 2001
Appl. No.:

09/771383
Inventors:

Kevin Delos Parris - Auburndale MA, US
William Stuart Somers - Cambridge MA, US
Amy Szepui Tam - Medford MA, US
Laura Long Lin - Weston MA, US
Mark Lloyd Stahl - Lexington MA, US
Assignee:

Wyeth - Madison NJ
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:

G06F019/00
G01N033/48
G01N031/00
US Classification:

702 27, 702 19, 702 22
Abstract:

This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.

Crystals Of An Acyl Carrier Protein Synthase/Acyl Carrier Protein Complex
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US Patent:

7135319, Nov 14, 2006
Filed:

Nov 19, 2003
Appl. No.:

10/717138
Inventors:

Kevin Delos Parris - Auburndale MA, US
William Stuart Somers - Cambridge MA, US
Amy Szepui Tam - Medford MA, US
Laura Long Lin - Weston MA, US
Mark Lloyd Stahl - Lexington MA, US
Assignee:

Wyeth - Madison NJ
International Classification:

C12N 9/10
US Classification:

435193, 530300, 530344
Abstract:

This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

Structure Of Protein Kinase C Theta
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US Patent:

7584087, Sep 1, 2009
Filed:

Apr 6, 2005
Appl. No.:

11/099958
Inventors:

Zhang Bao Xu - Tewksbury MA, US
Stephane Olland - Arlington MA, US
Scott Wolfrom - Somerville MA, US
Karl Malakian - Boxborough MA, US
Laura Lin - Weston MA, US
Mark Stahl - Lexington MA, US
Julie Lee - Somerville MA, US
Lori Fitz - Somerville MA, US
Rita Greco - Charlestown MA, US
Divya Chaudhary - Andover MA, US
William Stuart Somers - Lexington MA, US
Lidia Mosyak - Newton MA, US
Assignee:

Wyeth - Madison NJ
International Classification:

G06G 7/58
G01N 31/00
G01N 33/573
G01N 33/53
C12Q 1/00
C12Q 1/48
C12N 9/99
C12N 9/12
US Classification:

703 11, 702 27, 435 4, 435 74, 435 771, 435 15, 435184, 435194
Abstract:

A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.

Antibodies Against Human Interleukin-13 And Pharmaceutical Compositions Thereof
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US Patent:

7615213, Nov 10, 2009
Filed:

Jun 9, 2005
Appl. No.:

11/149309
Inventors:

Marion T. Kasaian - Charlestown MA, US
Lioudmila Tchistiakova - Andover MA, US
Geertruida M. Veldman - Sudbury MA, US
Kimberly Ann Marquette - Somerville MA, US
Xiang-Yang Tan - Reading MA, US
Debra D. Donaldson - Medford MA, US
Laura Long Lin - Weston MA, US
Tania Shane - Newton MA, US
Amy Sze Pui Tam - Medford MA, US
Eric Feyfant - Lexington MA, US
Nancy L. Wood - Somerville MA, US
Lori J. Fitz - Somerville MA, US
Angela M. Widom - Acton MA, US
Kevin D. Parris - Auburndale MA, US
Samuel J. Goldman - Acton MA, US
Jose W. Saldanha - Middlesex, GB
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 39/395
US Classification:

4241331, 4241451, 5303873, 53038823
Abstract:

This application relates to antibodies, e. g. , humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e. g. , a human patient, one or more IL-13-associated disorders, e. g. , respiratory disorders (e. g. , asthma); atopic disorders (e. g. , allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e. g. , atopic dermatitis), and gastrointestinal organs (e. g. , inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.

Antibodies Against Human Interleukin-13 And Uses Therefor
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US Patent:

8221752, Jul 17, 2012
Filed:

Oct 8, 2009
Appl. No.:

12/575896
Inventors:

Marion T. Kasaian - Cambridge MA, US
Lioudmila Gennadievna Tchistiakova - Andover MA, US
Geertruida Machteld Veldman - Sudbury MA, US
Kimberly Ann Marquette - Somerville MA, US
Xiang-Yang Tan - Reading MA, US
Debra D. Donaldson - Medford MA, US
Laura Long Lin - Weston MA, US
Tania Shane - Newton MA, US
Amy Sze Pui Tam - Medford MA, US
Eric Feyfant - Lexington MA, US
Nancy L. Wood - Somerville MA, US
Lori J. Fitz - Somerville MA, US
Angela M. Widom - Acton MA, US
Kevin D. Parris - Auburndale MA, US
Samuel J. Goldman - Acton MA, US
Jose W. Saldanha - Enfield, GB
Assignee:

Wyeth LLC - Madison NJ
International Classification:

A61K 39/395
US Classification:

4241331, 4241581
Abstract:

This application relates to antibodies, e. g. , humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e. g. , a human patient, one or more IL-13-associated disorders, e. g. , respiratory disorders (e. g. , asthma); atopic disorders (e. g. , allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e. g. , atopic dermatitis), and gastrointestinal organs (e. g. , inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.

Methods For Identifying Agents That Interact With An Active Site
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US Patent:

20030211588, Nov 13, 2003
Filed:

Jan 25, 2001
Appl. No.:

09/770834
Inventors:

Kevin Parris - Auburndale MA, US
William Somers - Cambridge MA, US
Amy Tam - Medford MA, US
Laura Lin - Weston MA, US
Mark Stahl - Lexington MA, US
Robert Powers - Westford MA, US
International Classification:

C12N009/10
G06F019/00
G01N033/48
G01N033/50
G01N031/00
US Classification:

435/193000, 702/019000
Abstract:

This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.

Anti-Il-13 Antibodies And Complexes
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US Patent:

20070048785, Mar 1, 2007
Filed:

Jun 9, 2005
Appl. No.:

11/149025
Inventors:

Laura Lin - Weston MA, US
Kevin Parris - Auburndale MA, US
Amy Sze Tam - Medford MA, US
Xiang-Yang Tan - Reading MA, US
Tania Shane - Newton MA, US
John Dumas - Arlington MA, US
James Wilhelm - Boston MA, US
Mark Stahl - Lexington MA, US
Lidia Mosyak - Newton MA, US
Zhixiang Hu - Spring TX, US
International Classification:

C07K 16/28
G01N 33/53
G06F 19/00
US Classification:

435007100, 530388220, 702019000
Abstract:

Anti-IL-13 antibodies, crystals of anti-IL-13 antibodies, IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13 polypeptide/anti-IL-13 antibody complexes, IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, and related methods and software systems are disclosed.

Muteins Of Clotting Factor Vlll
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US Patent:

20200392205, Dec 17, 2020
Filed:

Feb 24, 2020
Appl. No.:

16/799750
Inventors:

- New York NY, US
Debra Pittman - Windham NH, US
Mark Stahl - Lexington MA, US
Laura Lin - Weston MA, US
Justin Cohen - Quincy MA, US
International Classification:

C07K 14/755
A61K 38/00
A61K 47/61
A61K 38/37
Abstract:

The present disclosure provides muteins of FVIII to which a biocompatible polymer may be attached to increase the circulatory half-life of the muteins, as well as conjugates of such muteins and biocompatible polymers.