Laura Segatori

US Patent:

20070243583, Oct 18, 2007

Filed:

Apr 5, 2007

Appl. No.:

11/697114

Inventors:

George Georgiou - Austin TX, US
Laura Segatori - Houston TX, US

International Classification:

C12N 9/90
C12P 21/06
C07H 21/04
C12N 1/21
C12N 15/74

US Classification:

435069100, 435488000, 435252330, 435233000, 536023200

Abstract:

The present invention provides artificial enzymes comprising, e.g., an N-terminal domain derived from FkpA that allows for dimerization and provides a substrate binding region, and a C-terminal thioredoxin domain derived from DsbA. Similar to DsbC, such de novo designed chimeric (hybrid) FkpA-DsbA enzymes function, as disulfide reductases, oxidases, or isomerases, and chaperones in vivo and in vitro, despite lacking similarity toDsbC-related polypeptide sequence.

US Patent:

20090203605, Aug 13, 2009

Filed:

Feb 2, 2009

Appl. No.:

12/364441

Inventors:

Laura Segatori - Houston TX, US
Ting-Wei Mu - San Diego CA, US
Jeffrey W. Kelly - La Jolla CA, US

Assignee:

THE SCRIPPS RESEARCH INSTITUTE - LA JOLLA CA

International Classification:

A61K 38/16
A61K 31/7088
A61P 3/00

US Classification:

514 12

Abstract:

Methods are provided for treating conditions characterized by dysfunction in protein homeostasis in a patient in need thereof. A method for treating a condition characterized by dysfunction in protein homeostasis in a patient in need thereof is provided which comprises administering to the patient a proteostasis regulator in an amount effective to improve or restore protein homeostasis, and to reduce or eliminate the condition in the patient or to prevent its occurrence or recurrence. The condition can be a loss of function disorder such as a lysosomal storage disease, or a gain of function disorder such as an aging associated disease.

US Patent:

20130040405, Feb 14, 2013

Filed:

Aug 13, 2012

Appl. No.:

13/584419

Inventors:

Laura Segatori - Houston TX, US
Sibani Lisa Biswal - Houston TX, US
Jinghui Wang - Houston TX, US
Patricia D. Palena - Plainsboro NJ, US
Michael J. DiMario - Skillman NJ, US

Assignee:

Lockheed Martin Corporation - Moorestown NJ
William Marsh Rice University - Houston TX

International Classification:

G01N 33/557
G01N 29/036
G01N 21/21
G01N 21/55

US Classification:

436501

Abstract:

In some embodiments, the present invention provides methods of detecting a molecule in a sample, such as an explosive. In some embodiments, the method comprises: associating the sample with an antigen/binding agent complex; measuring a rate of displacement of the binding agent from the antigen by the molecule in the sample; and correlating the measured rate of displacement to the presence of the molecule in the sample. In some embodiments, the measuring step comprises a determination of a change in frequency of the sample and a change in energy dissipation of the sample over a time interval. In some embodiments, the correlating step comprises a calculation of a ratio of a change in energy dissipation of the sample over a change in frequency of the sample over the time interval. In some embodiments, the method is used to determine the molecule concentration in the sample.