Laura Elizabeth Vitale

US Patent:

7456264, Nov 25, 2008

Filed:

May 21, 2004

Appl. No.:

10/850635

Inventors:

Tibor Keler - Ottsville PA, US
Israel Lowy - Dobbs Ferry NY, US
Laura A. Vitale - Doylestown PA, US
Diann Blanset - Hillsborough NJ, US
Mohan Srinivasan - Cupertino CA, US

Assignee:

Medarex, Inc. - Princeton NJ

International Classification:

C07K 16/12
A61K 39/40
G01N 33/569

US Classification:

5303884, 4241421, 4241501, 436512, 436513

Abstract:

Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e. g. , a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e. g. , bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

US Patent:

8236318, Aug 7, 2012

Filed:

Nov 7, 2008

Appl. No.:

12/266745

Inventors:

Tibor Keler - Ottsville PA, US
Lizhen He - Allentown PA, US
Venky Ramakrishna - Riegelsville PA, US
Laura A. Vitale - Doylestown PA, US

Assignee:

Celldex Therapeutics Inc. - Needham MA

International Classification:

A61K 39/00
A61K 39/395

US Classification:

4241781, 4241531

Abstract:

Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

US Patent:

8318165, Nov 27, 2012

Filed:

Sep 10, 2007

Appl. No.:

12/439912

Inventors:

Tibor Keler - Ottsville PA, US
Laura A. Vitale - Doylestown PA, US
Lizhen He - Allentown PA, US

Assignee:

Celldex Therapeutics Inc. - Needham MA

International Classification:

A61K 39/395

US Classification:

4241381, 4241391, 4241411, 5303871, 5303877

Abstract:

The present invention provides isolated antibodies (e. g. , humanized or human antibodies) that bind to the membrane-proximal domain (MP) of human Melanoma-Associated Chondroitin Sulphate Proteoglycan (MCSP), and are capable of mediating cytolysis of a cell expressing MCSP in the presence of human effector cells or complement. Methods of using such antibodies to induce cytolysis (e. g. , ADCC or CDCC) of cells expressing MP-MCSP are also provided.

US Patent:

8362214, Jan 29, 2013

Filed:

May 5, 2009

Appl. No.:

12/387654

Inventors:

Tibor Keler - Ottsville PA, US
Lizhen He - Allentown PA, US
Venky Ramakrishna - Riegelsville PA, US
Laura A. Vitale - Doylestown PA, US

Assignee:

Celldex Therapeutics Inc. - Needham MA

International Classification:

C07K 16/00
C07K 17/00
C07K 17/14
C12P 21/08

US Classification:

5303887, 53038815, 5303911

Abstract:

Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.

US Patent:

8404820, Mar 26, 2013

Filed:

Oct 7, 2008

Appl. No.:

12/247032

Inventors:

Tibor Keler - Ottsville PA, US
Israel Lowy - Dobbs Ferry NY, US
Laura A. Vitale - Doylestown PA, US
Diann Blanset - Hillsborough NJ, US
Mohan Srinivasan - Cupertino CA, US

Assignee:

Medarex, Inc. - Princeton NJ

International Classification:

C07K 16/12
A61K 39/40
G01N 33/569

US Classification:

5303884, 4241421, 4241501, 436512, 436513

Abstract:

Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e. g. , a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e. g. , bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

US Patent:

20110274685, Nov 10, 2011

Filed:

Apr 13, 2011

Appl. No.:

13/086286

Inventors:

Tibor KELER - Ottsville PA, US
Henry C. MARSH - Reading MA, US
Lizhen HE - Allentown PA, US
Laura A. VITALE - Doylestown PA, US
Lawrence J. THOMAS - Easton MA, US

Assignee:

CELLDEX THERAPEUTICS INC. - Needham MA

International Classification:

A61K 39/395
C12N 5/10
C12N 15/63
C07K 16/28
A61P 37/04

US Classification:

4241331, 53038815, 5303873, 5303889, 5303898, 4241411, 4353201, 435325

Abstract:

Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

US Patent:

20120213771, Aug 23, 2012

Filed:

Oct 19, 2011

Appl. No.:

13/276735

Inventors:

Tibor KELER - Ottsville PA, US
Henry C. MARSH - Reading MA, US
Lizhen HE - Allentown PA, US
Laura A. VITALE - Doylestown PA, US
Lawrence J. THOMAS - Easton MA, US

Assignee:

CELLDEX THERAPEUTICS INC. - Needham MA

International Classification:

A61K 39/395
C07K 16/28
C12N 15/63
C12N 5/18
G01N 33/53
C12N 1/21
A61P 37/04
A61P 35/00
C07K 16/46
C12N 5/02

US Classification:

4241331, 5303873, 53038815, 53038822, 5303891, 4353201, 4241431, 435375, 4241721, 435 721, 43525233, 435334

Abstract:

Isolated monoclonal antibodies which bind to human CD27 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

US Patent:

20120309031, Dec 6, 2012

Filed:

Jul 6, 2012

Appl. No.:

13/542909

Inventors:

Tibor KELER - Ottsville PA, US
Lizhen HE - Allentown PA, US
Venky RAMAKRISHNA - Riegelsville PA, US
Laura A. VITALE - Doylestown PA, US

Assignee:

CELLDEX THERAPEUTICS INC. - Needham MA

International Classification:

C12N 15/13
G01N 33/566
C12N 1/19
G01N 21/64
C12N 1/15
C12N 15/63
C12N 5/10

US Classification:

435 724, 536 2353, 4353201, 435334, 435419, 43525411, 4352542

Abstract:

Isolated monoclonal antibodies which bind to human DEC-205 and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antib