Jill Ann Panetta - Zionsville IN John Kevin Shadle - Fishers IN Lawrence Joseph Heinz - Pittsboro IN Michael LeRoy Phillips - Indianapolis IN John Robert Rizzo - Indianapolis IN Benjamin Alan Anderson - Zionsville IN David Lee Varie - Indianapolis IN
Jill Ann Panetta - Zionsville IN John Kevin Shadle - Fishers IN Lawrence Joseph Heinz - Pittsboro IN Michael LeRoy Phillips - Indianapolis IN John Robert Rizzo - Indianapolis IN Benjamin Alan Anderson - Zionsville IN David Lee Varie - Indianapolis IN
Benjamin Alan Anderson - Zionsville IN Lawrence Joseph Heinz - Pittsboro IN Jill Ann Panetta - Zionsville IN Michael LeRoy Phillips - Indianapolis IN John Robert Rizzo - Indianapolis IN John Kevin Shadle - Fishers IN David Lee Varie - Indianapolis IN
The present invention provides a process of preparing a compound of the formula IV wherein: R and R are each individually -(C -C )alkyl, -(C -C )alkoxy or phenyl, R is H or -(C -C )alkyl, R is âNR R , morpholin-1-yl, imidazol-1-yl, 4,5-dihydro-1H-imidazol-2-yl, thiomorpholin-1-yl, piperazin-1-yl or piperazin-1-yl substituted with -(C -C )alkyl or âand R and R are each individually hydrogen, -(C -C )alkyl, â(CH ) OH, ââ(CH ) -piperidyl, â(CH ) S(C -C )alkyl, â(CH ) O(C -C )alkyl âwhere R is (C -C )alkyl; P is an integer from 1-3 both inclusive; q is 0 or 1; and t is 1 to 6 both inclusive; or a pharmaceutically acceptable salt, hydrate or optical isomer thereof, which is useful as a neuroprotective agent.
Methods Of Using Compounds As Neuro-Protective Agents
Jill Ann Panetta - Zionsville IN John Kevin Shadle - Fishers IN Lawrence Joseph Heinz - Pittsboro IN Michael LeRoy Phillips - Indianapolis IN John Robert Rizzo - Indianapolis IN Benjamin Alan Anderson - Zionsville IN David Lee Varie - Indianapolis IN
Jill Ann Panetta - Zionsville IN John Kevin Shadle - Fishers IN Lawrence Joseph Heinz - Pittsboro IN Michael LeRoy Phillips - Indianapolis IN John Robert Rizzo - Indianapolis IN Benjamin Alan Anderson - Zionsville IN David Lee Varie - Indianapolis IN
James Ronald Gillig - Indianapolis IN, US Lawrence Joseph Heinz - Pittsboro IN, US Michael Dean Kinnick - Indianapolis IN, US John Michael Morin - Brownsburg IN, US Nancy June Snyder - Lizton IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 31/165 C07C 55/06 C07C 323/42
US Classification:
514618, 562597, 564162
Abstract:
The present invention relates to a melanin concentrating hormone antagonist compound of Formula I: (I) wherein Ar, Ar, Ar, L, Land Q areas defined, or a pharmaceutically acceptable salt, solvate, enantiomer or mixture of diastereomers thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and Related Diseases.
Multicyclic Compounds For Use As Melanin Concentrating Hormone Antagonists In The Treatment Of Obesity And Diabetes
Jochen Ammenn - Hamburg, DE James Ronald Gillig - Indianapolis IN, US Lawrence Joseph Heinz - Pittsboro IN, US Philip Arthur Hipskind - New Palestine IN, US Michael Dean Kinnick - Indianapolis IN, US James Arthur Nixon - Indianapolis IN, US Carsten Ott - Bad Segeberg, DE Kenneth Allen Savin - Indianapolis IN, US Theo Schotten - Vierhoefen, DE Lawrence John Slieker - Carmel IN, US Nancy June Snyder - Lizton IN, US Michael Alan Robertson - Indianapolis IN, US
The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
Benzenesulfonic Acid Indol-5-Yl Esters As Antagonists Of The 5Ht Receptor
Sandra Ann Filla - Franklin IN, US Michael Edward Flaugh - Indianapolis IN, US James Ronald Gillig - Indianapolis IN, US Lawrence Joseph Heinz - Pittsboro IN, US Bin Liu - Fishers IN, US John Mehnert Schaus - Zionsville IN, US John Stanley Ward - Redwood City CA, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 31/454 A61K 31/4545 C07D 401/04 C07D 401/14
US Classification:
514323, 514318, 514339, 546194, 546201, 5462774
Abstract:
The present invention relates to compounds of formula I: which are antagonists of 5-HT6 receptor.
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