Lawrence J Martin

US Patent:

51531933, Oct 6, 1992

Filed:

Oct 1, 1991

Appl. No.:

7/769268

Inventors:

Denise M. Flanagan - Bridgewater NJ
Lawrence L. Martin - Lebanon NJ

Assignee:

Hoechst-Roussel Pharmaceuticals Incorporated - Somerville NJ

International Classification:

A61K 3140
A61K 31535
C07D48704

US Classification:

5142288

Abstract:

There are disclosed various compounds of the formula below, ##STR1## where the parameters R. sub. 1 and R. sub. 2 are as defined in the specification, which compounds are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.

US Patent:

53289200, Jul 12, 1994

Filed:

Oct 21, 1992

Appl. No.:

7/964546

Inventors:

Richard C. Effland - Bridgewater NJ
Joseph T. Klein - Bridgewater NJ
Lawrence L. Martin - Lebanon NJ
Gregory M. Shutske - Flemington NJ
Kevin J. Kapples - Little York NJ
John D. Tomer - Perkasie PA

Assignee:

Hoechst-Roussel Pharmaceuticals Incorporated - Somerville NJ

International Classification:

C07D40112
A61K 3144

US Classification:

514339

Abstract:

There are disclosed various compounds of the formula below, ##STR1## where R, R. sub. 1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorder.

US Patent:

53289188, Jul 12, 1994

Filed:

Mar 25, 1993

Appl. No.:

8/038317

Inventors:

Richard C. Effland - Bridgewater NJ
Joseph T. Klein - Bridgewater NJ
Lawrence L. Martin - Lebanon NJ

Assignee:

Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ

International Classification:

C07D40112
A61K 3144

US Classification:

514338

Abstract:

This invention relates to substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo[b]thiophenes and 1,2-benzisothiazoles of the formula ##STR1## wherein Q is S, N or NR. sub. 2 ; Y is CH, N or NR. sub. 2 ; R. sub. 1 is hydrogen, loweralkyl, loweralkynyl, loweralkenyl, arylloweralkyl, loweralkoxycarbonylaminoloweralkylcarbonyl, arylloweralkoxycarbonylaminoloweralkylcarbonyl, aminoloweralkylcarbonyl, loweralkoxycarbonyl or acyl; R. sub. 2 is hydrogen or loweralkyl; R. sub. 3 is hydrogen or loweralkyl; X is hydrogen, loweralkyl, halogen; and n is 0 or 1; or a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful in the treatment of memory dysfunctions characterized by a cholinergic deficit such as the type associated with Alzheimer's disease and other memory disorders. Compounds of this invention also have utility as modulators of neurotransmitter function such as noradrenergic and serotonergic and as such are useful for treatment of depression and personality disorders such as obsessive compulsive disorders. Additionally, compounds of this invention are useful as topical antiinflammatory agents for the treatment of various dermatoses.

US Patent:

51853507, Feb 9, 1993

Filed:

Sep 23, 1991

Appl. No.:

7/764031

Inventors:

Richard C. Effland - Bridgewater NJ
Joseph T. Klein - Bridgewater NJ
Lawrence L. Martin - Lebanon NJ

Assignee:

Hoechst-Roussel Pharmaceuticals Incorporated - Somerville NJ

International Classification:

C07D40102
A61K 3144

US Classification:

514339

Abstract:

This invention relates to substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo[b]thiophenes and 1,2-benzisothiazoles of the formula ##STR1## wherein Q is S, N or NR. sub. 2 ; Y is CH, N or NR. sub. 2 ; R. sub. 1 is hydrogen, loweralkyl, loweralkynyl, loweralkenyl, arylloweralkyl, loweralkoxycarbonylaminoloweralkylcarbonyl, arylloweralkoxycarbonylaminoloweralkylcarbonyl, aminoloweralkylcarbonyl, loweralkoxycarbonyl or acyl; R. sub. 2 is hydrogen or loweralkyl; R. sub. 3 is hydrogen or loweralkyl; X is hydrogen, loweralkyl, halogen; and n is 0 or 1; or a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful in the treatment of memory dysfunctions characterized by a cholinergic deficit such as the type associated with Alzheimer's disease and other memory disorders. Compounds of this invention also have utility as modulators of neurotransmitter function such as noradrenergic and serotonergic and as such are useful for treatment of depression and personality disorders such as obsessive compulsive disorders. Additionally, compounds of this invention are useful as topical antiinflammatory agents for the treatment of various dermatoses.

US Patent:

55918662, Jan 7, 1997

Filed:

Jun 1, 1995

Appl. No.:

8/457723

Inventors:

Raymond W. Kosley - Bridgewater NJ
Denise M. Flanagan - Bridgewater NJ
Lawrence L. Martin - Lebanon NJ
Peter A. Nemoto - Piscataway NJ

Assignee:

Hoechst Marion Roussel Inc. - Bridgewater NJ

International Classification:

C07D40304

US Classification:

548455

Abstract:

There are disclosed compounds having the formula ##STR1## wherein the variables are defined in the specification, and pharmaceutically acceptable addition salts thereof, or where applicable, the optical or geometrical isomers or racemic mixtures thereof, intermediates in the process for making the compounds, a process for making the compounds and pharmaceutical compositions and method of use as neuroprotective agents.

US Patent:

52349411, Aug 10, 1993

Filed:

Aug 5, 1992

Appl. No.:

7/924998

Inventors:

Denise M. Flanagan - Bridgewater NJ
Lawrence L. Martin - Lebanon NJ

Assignee:

Hoechst-Roussel Pharmaceuticals Incorporated - Somerville NJ

International Classification:

C07D48704
A61K 3140

US Classification:

514411

Abstract:

There are disclosed various compounds of the formula below, ##STR1## where the parameters R. sub. 1 and R. sub. 2 are as defined in the specification, which compounds are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.

US Patent:

56312709, May 20, 1997

Filed:

Jun 5, 1995

Appl. No.:

8/464994

Inventors:

Richard C. Effland - Bridgewater NJ
Joseph T. Klein - Bridgewater NJ
Lawrence L. Martin - Lebanon NJ

Assignee:

Hoechst Marion Roussel, Inc. - Cincinnati OH

International Classification:

A61K 3144
A61K 3138
A61K 31405
A61K 31415

US Classification:

514337

Abstract:

This invention relates to substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzo[b]thiophenes and 1,2-benzisothiazoles of the formula ##STR1## wherein Q is S, N or NR. sub. 2 ; Y is CH, N or NR. sub. 2 ; R. sub. 1 is hydrogen, loweralkyl, loweralkynyl, loweralkenyl, arylloweralkyl, loweralkoxycarbonylaminoloweralkylcarbonyl, arylloweralkoxycarbonylaminoloweralkylcarbonyl, aminoloweralkylcarbonyl, loweralkoxycarbonyl or acyl; R. sub. 2 is hydrogen or loweralkyl; R. sub. 3 is hydrogen or loweralkyl; X is hydrogen, loweralkyl, halogen; and n is 0 or 1; or a pharmaceutically acceptable acid addition salt thereof that are useful in the treatment of memory dysfunctions.

US Patent:

55190324, May 21, 1996

Filed:

Oct 6, 1993

Appl. No.:

8/132731

Inventors:

Richard C. Effland - Bridgewater NJ
Joseph T. Klein - Bridgewater NJ
Lawrence L. Martin - Lebanon NJ

Assignee:

Hoechst Marion Roussel Inc. - Somerville NJ

International Classification:

A61K 3144
C07D49504

US Classification:

514301

Abstract:

This application relates to compounds of the formula ##STR1## wherein R. sup. 1, R. sup. 2, R. sup. 3, m and n are as defined in the specification which are useful as modulators of neurotransmitter function such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorders. Certain of the compounds are also useful as glycine partial agonists.