Lei Raymond Cao

US Patent:

20110274718, Nov 10, 2011

Filed:

Oct 29, 2009

Appl. No.:

13/126026

Inventors:

Matthew J. During - Columbus OH, US
Lei Cao - Columbus OH, US

Assignee:

THE OHIO STATE UNIVERSITY - Columbus OH

International Classification:

A61K 39/00
A61K 31/7088
C12N 15/63
A61K 38/18
A61P 3/00
A61P 35/00
A61P 3/04
A61P 3/10
A61P 37/04
A61P 25/00
A61K 48/00
C07H 21/02

US Classification:

4241981, 514 44 R, 514 44 A, 4353201, 514 83, 536 245

Abstract:

Methods for treating tumor associated diseases by administering a nucleic acid sequence encoding brain derived neurotrophic factor (BDNF) where the expression reduces the symptoms of the disease and compositions for mediation of enrichment-induced tumor resistance having brain derived neurotrophic factor (BDNF) are disclosed.

US Patent:

20110288160, Nov 24, 2011

Filed:

Mar 27, 2009

Appl. No.:

12/934735

Inventors:

Matthew J. During - Columbus OH, US
Lei Cao - Columbus OH, US

Assignee:

THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION - Columbus OH

International Classification:

A61K 48/00
C12N 15/85
C12N 15/86
A61P 3/08
A61P 3/00
A61P 3/10
A61P 3/04
C12N 15/63
C12N 15/861

US Classification:

514 44 R, 4353201, 435455

Abstract:

Described herein is a system which uses a gene therapy particle that includes at least one gene, cDNA, fragment or analogue of at least one neurotropin that binds to the trkB receptor or the trkB receptor itself. The gene therapy particle is capable of being delivered to a subject in need thereof for therapy of a metabolic disorder. In a particular aspect, this invention is directed to an inventive method that demonstrates a remarkable efficacy on lowering body weight.

US Patent:

20140057837, Feb 27, 2014

Filed:

Aug 21, 2013

Appl. No.:

13/971968

Inventors:

Matthew During - Columbus OH, US
Lei Cao - Columbus OH, US

International Classification:

A61K 38/18
A61K 31/353
A61K 31/24
A61K 31/135
A61K 31/138
A61K 31/7088
A61K 31/4045

US Classification:

514 48, 514 44 R, 514456, 514419, 514654, 514653, 514510

Abstract:

Methods for increasing the amount of brown adipose tissue in a subject, of increasing the ratio of brown fat to white fat in a subject, or for effecting a change in white adipose tissue to become brown adipose tissue in a subject include the administration of one or more agents. The agent can increase or induce hypothalamic expression of BDNF, can be a TrkB receptor agonist or a beta-3 adrenergic receptor agonist, or encode an agonist that modulates a hypothalamic-adipocyte axis.

US Patent:

20180372891, Dec 27, 2018

Filed:

Jun 19, 2018

Appl. No.:

16/012186

Inventors:

- Columbus OH, US
Lei Cao - Upper Arlington OH, US

International Classification:

G01T 3/08
G01T 1/24
G21H 1/02
H01L 31/115

Abstract:

Provided herein are charge generating devices and methods of making and use thereof. The charge generating devices comprise a substrate having a top surface; a plurality of spaced-apart three-dimensional elements disposed on the top surface of the substrate; and a plurality of cavities formed by the plurality of spaced-apart three-dimensional elements, the plurality of cavities being the area between the plurality of spaced-apart three-dimensional elements. The charge generating devices can further comprise a radioactive layer disposed on at least a portion of the plurality of spaced-apart three-dimensional elements and the top surface such that the plurality of cavities and the top surface are substantially coated by the radioactive layer. In some examples, the charge generating devices can comprise a radiation material and/or a scintillating material disposed within at least a portion of the plurality of cavities.

US Patent:

20150053863, Feb 26, 2015

Filed:

Feb 28, 2013

Appl. No.:

14/381764

Inventors:

Lei Cao - Columbus OH, US

International Classification:

G01T 1/24
H01L 31/0304
G01T 3/06
G01T 3/08
G01T 1/20
H01L 31/115
H01L 27/144

US Classification:

25037005, 257 76, 25037011

Abstract:

A device for detecting neutrons with gamma discrimination and/or gamma radiation includes a first semiconductor layer, a second semiconductor layer, an electron separator layer between the first semiconductor device and the second semiconductor device, and a gadolinium-containing layer between the first semiconductor layer and the second semiconductor layer.