Lei D Chen

US Patent:

7329495, Feb 12, 2008

Filed:

Jun 9, 2005

Appl. No.:

11/148770

Inventors:

Lei L. Chen - Pearland TX, US
Marsha L. Frazier - Houston TX, US

Assignee:

Board of Regents, the University of Texas System - Austin TX

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention relates to methods and compositions concerning resistance to a drug for cancer comprising aberrant KIT signal, such as aberrant KIT sequence or expression. In a specific embodiment, the cancer is also initially responsive to imatinib therapy, such as in gastrointestinal stromal tumors (GISTs). In particular embodiments, a mutation in a KIT polynucleotide confers resistance to imatinib treatment, and in specific embodiments the exemplary mutation is at 1982T→C. Thus, the invention provides a means to adjust for or circumvent the resistance to imatinib drug treatment.

US Patent:

20080213774, Sep 4, 2008

Filed:

Dec 17, 2007

Appl. No.:

11/957639

Inventors:

Lei L. Chen - Pearland TX, US
Marsha L. Frazier - Houston TX, US

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C12Q 1/68
C07H 21/00

US Classification:

435 6, 536 235

Abstract:

The present invention relates to methods and compositions concerning resistance to a drug for cancer comprising aberrant KIT signal, such as aberrant KIT sequence or expression. In a specific embodiment, the cancer is also initially responsive to imatinib therapy, such as in gastrointestinal stromal tumors (GISTs). In particular embodiments, a mutation in a KIT polynucleotide confers resistance to imatinib treatment, and in specific embodiments the exemplary mutation is at 1982T→C. Thus, the invention provides a means to adjust for or circumvent the resistance to imatinib drug treatment.

US Patent:

20120034254, Feb 9, 2012

Filed:

Feb 6, 2009

Appl. No.:

12/866723

Inventors:

Peter D. Kwong - Washington DC, US
Gary J. Nabel - Washington DC, US
George Shaw - Birmingham AL, US
William Schief - Seattle WA, US
Zhi-yong Yang - Potomac MD, US
Tongqing Zhou - Boyds MD, US
Lei Chen - Rockville MD, US
Young Do Kwon - Rockville MD, US

International Classification:

A61K 39/21
C07K 14/195
C07K 14/37
C07K 14/005
A61P 31/18
A61K 39/00
C07H 21/00
G01N 33/566
A61P 37/04
C07K 14/16
C07H 21/04

US Classification:

4241881, 530395, 530350, 536 2372, 4241841, 536 231, 4242081, 435 792

Abstract:

Disclosed are antigens that include a target epitope that is defined by atomic coordinates of those amino acids of the antigen that contact an antibody of interest that specifically binds the antigen. The disclosed antigens have between about 10% and about 90% of surface exposed amino acid residues located exterior of the target epitope substituted as compared to a wild-type antigen and less than about 10% of the non-surface exposed amino acid residues substituted as compared to a wild-type antigen. Also disclosed are nucleic acids encoding these antigens and methods of producing these antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject.

US Patent:

20210308650, Oct 7, 2021

Filed:

Oct 23, 2019

Appl. No.:

17/288179

Inventors:

- Bergen op Zoom, NL
Byeongjin Baek - Katy TX, US
Lei Chen - Sugar Land TX, US
Vladimir Shtern - Houston TX, US
Istvan Lengyel - Sugar Land TX, US
David West - Bellaire TX, US
Krishnan Sankaranarayanan - Missouri City TX, US

International Classification:

B01J 19/24
C07C 5/48
C10G 9/36

Abstract:

A reactor () and method for the conversion of hydrocarbon gases utilizes a reactor () having a unique feed assembly () with an original vortex disk-like inlet flow spaces (), a converging-diverging vortex mixing chamber (), and a cylindrical reactor chamber (). This design creates a small combustion zone and an inwardly swirling fluid flow pattern of the feed gases that passes through a converging conduit () with a constricted neck portion (). This provides conditions suitable for efficient cracking of hydrocarbons, such as ethane, to form olefins.

US Patent:

20210245128, Aug 12, 2021

Filed:

Apr 28, 2021

Appl. No.:

17/242610

Inventors:

- Bergen op Zoom, NL
Vladimir Shtern - Houston TX, US
Lei Chen - Sugar Land TX, US
David West - Bellaire TX, US

International Classification:

B01J 6/00
B01J 4/00
B01J 12/00
B01J 19/00
B01J 19/02
B01J 19/24
C07C 2/78

Abstract:

A pyrolysis reactor () and method for the pyrolysis of hydrocarbon gases (e.g., methane) utilizes a pyrolysis reactor () having a unique burner assembly () and pyrolysis feed assembly () that creates an inwardly spiraling fluid flow pattern of the feed gases to form a swirling gas mixture that passes through a burner conduit () with a constricted neck portion or nozzle (). At least a portion of the swirling gas mixture forms a thin, annular mixed gas flow layer immediately adjacent to the burner conduit (). A portion of the swirling gas mixture is combusted as the swirling gas mixture passes through the burner conduit () and a portion of combustion products circulates in the burner assembly (). This provides conditions suitable for pyrolysis of hydrocarbons or light alkane gas, such as methane or natural gas.

US Patent:

20210046440, Feb 18, 2021

Filed:

Mar 7, 2019

Appl. No.:

16/977644

Inventors:

- Bergen op Zoom, NL
Vladimir Shtern - Houston TX, US
Lei Chen - Sugar Land TX, US
David West - Bellaire TX, US

International Classification:

B01J 6/00
C07C 2/78
B01J 12/00
B01J 19/02
B01J 19/00
B01J 19/24
B01J 4/00

Abstract:

A pyrolysis reactor () and method for the pyrolysis of hydrocarbon gases (e.g., methane) utilizes a pyrolysis reactor () having a unique burner assembly () and pyrolysis feed assembly () that creates an inwardly spiraling fluid flow pattern of the feed gases to form a swirling gas mixture that passes through a burner conduit () with a constricted neck portion or nozzle (). At least a portion of the swirling gas mixture forms a thin, annular mixed gas flow layer immediately adjacent to the burner conduit (). A portion of the swirling gas mixture is combusted as the swirling gas mixture passes through the burner conduit () and a portion of combustion products circulates in the burner assembly (). This provides conditions suitable for pyrolysis of hydrocarbons or light alkane gas, such as methane or natural gas.

US Patent:

20180319846, Nov 8, 2018

Filed:

Jul 2, 2018

Appl. No.:

16/025858

Inventors:

- Bethesda MD, US
Barney S. Graham - Rockville MD, US
Jason S. McLellan - Austin TX, US
Jeffrey Boyington - Clarksburg MD, US
Lei Chen - Rockville MD, US
Man Chen - Bethesda MD, US
Ivelin Stefanov Georgiev - Nashville TN, US
Jason Gorman - Washington DC, US
Michael Gordon Joyce - Washington DC, US
Masaru Kanekiyo - Chevy Chase MD, US
Gilad Ofek - Gaithersburg MD, US
Marie Pancera - Seattle WA, US
Mallika Sastry - Rockville MD, US
Cinque Soto - Rockville MD, US
Sanjay Srivatsan - Lilburn GA, US
Guillaume Stewart-Jones - Bethesda MD, US
Yongping Yang - Potomac MD, US
Baoshan Zhang - Bethesda MD, US
Tongqing Zhou - Boyds MD, US

Assignee:

The United States of America,as represented by the Secretary,Department of Helath and Human Services - Bethesda MD

International Classification:

C07K 14/005
A61K 39/155
C12N 7/00
A61K 39/12
G01N 33/564
A61K 39/00

Abstract:

Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

US Patent:

20160046675, Feb 18, 2016

Filed:

Mar 13, 2014

Appl. No.:

14/776651

Inventors:

- Bethesda MD, US
Barney S. Graham - Rockville MD, US
Jason S. McLellan - Norwich VT, US
Jeffrey Boyington - Clarksburg MD, US
Lei Chen - Rockville MD, US
Man Chen - Bethesda MD, US
Ivelin Stefanov Georgiev - Gaithersburg MD, US
Jason Gorman - Washington DC, US
Michael Gordon Joyce - Washington DC, US
Masaru Kanekiyo - Chevy Chase MD, US
Gilad Ofek - Gaithersburg MD, US
Marie Pancera - McLean VA, US
Mallika Sastry - Rockville MD, US
Cinque Soto - Rockville MD, US
Sanjay Srivatsan - Lilburn GA, US
Guillaume Stewart-Jones - Bethesda MD, US
Yongping Yang - Potomac MD, US
Baoshan Zhang - Bethesda MD, US
Tongqing Zhou - Boyds MD, US

Assignee:

The USA, as represented by the Secretary, Departm- ent of Health and Human Service - Bethesda MD

International Classification:

C07K 14/005
A61K 39/155
G01N 33/564
C12N 7/00

Abstract:

Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.