Lekhanh Ong Tran from 14248 Greater Pines Blvd, Clermont, FL 34711, age 59, Phone: 3524325742

Us Patents

Hiv Integrase Inhibitors
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US Patent:

6380249, Apr 30, 2002
Filed:

Jun 1, 1999
Appl. No.:

09/323417
Inventors:

Steven D. Young - Lansdale PA
Melissa Egbertson - Ambler PA
Linda S. Payne - Lansdale PA
John S. Wai - Harleysville PA
Thorsten E. Fisher - Hatfield PA
Mark W. Embrey - North Wales PA
Lekhanh Tran - Norristown PA
Linghang Zhuang - Conshohocken PA
Joseph P. Vacca - Telford PA
H. Marie Langford - Lansdale PA
Jeffrey Melamed - Warminster PA
Juan C. Jaen - Burlingame CA
David L. Clark - Albany CA
Julio C. Medina - Belmont CA
Assignee:

Merck Co., Inc. - Rahway NJ
Tularik Inc. - S. San Francisco CA
International Classification:

A61K 31215
US Classification:

514530, 514531, 514538, 514539, 514541, 560 19, 560 48, 560 51, 560 53, 562426, 562433, 562441, 562451, 562452, 562457, 562459, 562462, 562463
Abstract:

Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Thrombin Inhibitors
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US Patent:

6515011, Feb 4, 2003
Filed:

Dec 18, 2001
Appl. No.:

10/023776
Inventors:

Harold G. Selnick - Ambler PA
James C. Barrow - Harleysville PA
Philippe G. Nantermet - Lansdale PA
Peter D. Williams - Harleysville PA
Kenneth J. Stauffer - Souderton PA
Philip E. Sanderson - Philadelphia PA
Kenneth E. Rittle - Green Lane PA
Matthew M. Morrissette - Pottstown PA
Catherine M. Wiscount - Allentown PA
Lekhanh O. Tran - Norristown PA
Terry A. Lyle - Lederach PA
Donnette D. Staas - Harleysville PA
Assignee:

Merck Co., Inc. - Rahway NJ
International Classification:

A61K 3140
US Classification:

514423, 548538, 548528, 548518, 546111, 5462791, 514422, 514343, 514290
Abstract:

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e. g. where R is âCH NH , âCH CH NH , or âCH NHC(O)OC(CH ).

Thrombin Inhibitors
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US Patent:

6528503, Mar 4, 2003
Filed:

Jun 14, 2002
Appl. No.:

10/171708
Inventors:

Peter D. Williams - Harleysville PA
Terry A. Lyle - Lederach PA
Matthew M. Morrissette - Pottstown PA
Lekhanh O. Tran - Norristown PA
Donnette D. Staas - Harleysville PA
Assignee:

Merck Co., Inc. - Rahway NJ
International Classification:

A61K 31397
US Classification:

514210, 548953, 5462681, 514340
Abstract:

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, e. g. 1-(3(S)-Cyclopropyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide, and 1-(3-Cyclopropyl-3-methyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide.

Hydroxy Pyridopyrrolopyrazine Dione Compounds Useful As Hiv Integrase Inhibitors
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US Patent:

7435735, Oct 14, 2008
Filed:

Oct 18, 2004
Appl. No.:

10/576328
Inventors:

John S. Wai - Harleysville PA, US
Thorsten E. Fisher - Hatfield PA, US
Linghang Zhuang - Chalfont PA, US
Donnette D. Staas - Harleysville PA, US
Terry A. Lyle - Lederach PA, US
Boyoung Kim - Lansdale PA, US
Mark W. Embrey - North Wales PA, US
Catherine M. Wiscount - Allentown PA, US
Lekhanh O. Tran - Norristown PA, US
Melissa Egbertson - Ambler PA, US
Kelly L. Savage - Schwenksville PA, US
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A01N 43/58
A01N 43/60
A61K 31/50
A61K 31/495
C07D 471/00
C07D 487/00
C07D 241/36
US Classification:

514250, 544345
Abstract:

Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R, R, R, R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Aza- And Polyaza-Naphthalenyl Carboxamides Useful As Hiv Integrase Inhibitors
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US Patent:

20030055071, Mar 20, 2003
Filed:

Oct 10, 2001
Appl. No.:

09/973853
Inventors:

Neville Anthony - Hatfield PA, US
Robert Gomez - Perkasie PA, US
Steven Young - Lansdale PA, US
Melissa Egbertson - Ambler PA, US
John Wai - Harleysville PA, US
Linghang Zhuang - Chalfont PA, US
Mark Embrey - North Wales PA, US
LeKhanh Tran - Norristown PA, US
Jeffrey Melamed - Doylestown PA, US
H. Langford - Lansdale NJ, US
James Guare - Quakertown PA, US
Thorsten Fisher - Hatfield PA, US
Samson Jolly - Quakertown PA, US
Michelle Kuo - Gwynedd Valley PA, US
Debra Perlow - East Greenville PA, US
Jennifer Bennett - East Norriton PA, US
Timothy Funk - Ephrata PA, US
International Classification:

C07D471/02
A61K031/519
A61K031/4745
A61K031/47
US Classification:

514/264100, 514/307000, 514/312000, 544/279000, 546/156000, 546/141000, 546/123000, 514/300000
Abstract:

Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

1-(Aromatic- Or Heteroaromatic-Substituted)-3-(Heteroaromatic Substituted)-1,3-Propanediones And Uses Thereof
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US Patent:

20030229079, Dec 11, 2003
Filed:

Jun 6, 2003
Appl. No.:

10/260029
Inventors:

Linda Payne - Lansdale PA, US
Lekhanh Tran - Norristown PA, US
Linghang Zhuang - Chalfont PA, US
Steven Young - Lansdale PA, US
Melissa Egbertson - Ambler PA, US
John Wai - Harleysville PA, US
Mark Embrey - North Wales PA, US
Thorsten Fisher - Hatfield PA, US
James Guare - Quakertown PA, US
H. Marie Langford - Lansdale PA, US
Jeffrey Melamed - Warminster PA, US
David Clark - Albany CA, US
International Classification:

A61K031/542
A61K031/538
A61K031/522
A61K031/498
A61K031/506
A61K031/497
A61K031/4439
US Classification:

514/222200, 514/230500, 514/256000, 514/255050, 514/263220, 514/341000, 544/047000, 544/105000, 544/277000, 544/331000, 544/405000, 544/350000, 546/268100, 514/249000
Abstract:

Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

Aza- And Polyaza-Naphthalenyl Carboxamides Useful As Hiv Integrase Inhibitors
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US Patent:

20050176718, Aug 11, 2005
Filed:

Feb 11, 2005
Appl. No.:

11/056412
Inventors:

Neville Anthony - Hatfield PA, US
Robert Gomez - Perkasie PA, US
Steven Young - Lansdale PA, US
Melissa Egbertson - Ambler PA, US
John Wai - Harleysville PA, US
Linghang Zhuang - Chalfont PA, US
Mark Embrey - North Wales PA, US
Lekhanh Tran - Norristown PA, US
Jeffrey Melamed - Doylestown PA, US
H. Langford - Lansdale NJ, US
James Guare - Quakertown PA, US
Thorsten Fisher - Hatfield PA, US
Samson Jolly - Quakertown PA, US
Michelle Kuo - Gwynedd Valley PA, US
Debra Perlow - East Greenville PA, US
Jennifer Bennett - East Norriton PA, US
Timothy Funk - Ephrata PA, US
International Classification:

A61K031/498
A61K031/4745
C07D471/02
C07D487/02
US Classification:

514249000, 514300000, 544350000, 546123000
Abstract:

Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

Inhibitors Of Farnesyl-Protein Transferase
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US Patent:

59394390, Aug 17, 1999
Filed:

Dec 22, 1997
Appl. No.:

8/995744
Inventors:

Neville J. Anthony - Hatfield PA
Samuel L. Graham - Schwenksville PA
Lekhanh O. Tran - Norristown PA
Ian M. Bell - Harleysville PA
S. Jane deSolms - Norristown PA
Robert P. Gomez - Perkasie PA
Michelle Sparks Kuo - Gwynedd Valley PA
William C. Lumma - Pennsburg PA
Debra S. Perlow - East Greenville PA
Anthony W. Shaw - Lansdale PA
John S. Wai - Harleysville PA
Steven D. Young - Lansdale PA
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07D40104
A61K 3144
US Classification:

514333
Abstract:

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.