Leon M Wilkins

US Patent:

6730510, May 4, 2004

Filed:

Jul 2, 2002

Appl. No.:

10/189300

Inventors:

Eric Roos - Grafton MA
Christopher OReilly - Middleboro MA
Ruben Chevere - North Attleboro MA
Leon M. Wilkins - North Andover MA

Assignee:

Organogenesis, Inc. - Canton MA

International Classification:

C12M 134

US Classification:

4352883, 4352975, 4353054

Abstract:

A bioreactor has a base for defining a well, a dish with a membrane suspended in the base, and a lid with gas permeable membranes and self-sealing ports.

US Patent:

20050282198, Dec 22, 2005

Filed:

May 3, 2005

Appl. No.:

11/121634

Inventors:

Gordon Duff - Sheffield, GB
Angela Cox - Sheffield, GB
Nicola Camp - Salt Lake City UT, US
Franceso diGiovine - Sheffield, GB
Kenneth Kornman - Newton MA, US
Leon Wilkins - North Andover MA, US
Hongmin Chen - Devens MA, US
John Rogus - North Andover MA, US

International Classification:

C12Q001/68

US Classification:

435006000

Abstract:

Methods and kits for determining whether a subject has or is predisposed to developing a disease which is associated with IL-1 polymorphisms and assays for identifying therapeutics for treating and/or preventing the development of these diseases are provided.

US Patent:

20070243158, Oct 18, 2007

Filed:

Jun 12, 2007

Appl. No.:

11/761893

Inventors:

Vincent Ronfard - West Newton MA, US
Alan Tuck - Sherborne MA, US
Leon Wilkins - North Andover MA, US

Assignee:

ORGANOGENESIS, INC. - Canton MA

International Classification:

A61Q 19/08
A61K 45/00
C12N 5/06
C12P 1/00

US Classification:

424085100, 435404000, 435041000

Abstract:

The invention is directed to compositions containing growth agents synthesized from cultured cells from skin. Skin cells such as keratinocytes and dermal fibroblasts are cultured in vitro in cell medium and in the course of culture the cultured cells synthesize and secrete agents into the cell medium. The medium containing agents are collected and incorporated into pharmaceutical or cosmetic preparations to treat an individual. The preparation is applied and has a rejuvenating effect on the cells and tissue.

US Patent:

20070275104, Nov 29, 2007

Filed:

May 14, 2007

Appl. No.:

11/748129

Inventors:

Kenneth Kornman - Newton MA, US
Leon Wilkins - North Andover MA, US

International Classification:

A61K 36/82
A61K 36/73
A61K 36/53

US Classification:

424729000, 424745000, 424765000, 424769000

Abstract:

The invention provides a method of alleviating a sign or symptom of periodontal disease in a subject, by administering to the subject a composition containing a natural compound which inhibits matrix metalloproteinase activity and interleukin-1 activity.

US Patent:

20080118920, May 22, 2008

Filed:

May 3, 2005

Appl. No.:

11/579296

Inventors:

Gordon W. Duff - South Yorkshire, GB
Kenneth S. Kornman - Newton MA, US
Leon Wilkins - North Andover MA, US
Hongmin Chen - Devens MA, US
John Rogus - North Andover MA, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Methods and kits for determining whether a subject has or is predisposed to developing a disease which is associated with IL-1 polymorphisms and assays for identifying therapeutics for treating and/or preventing the development of these diseases are provided.

US Patent:

20080199545, Aug 21, 2008

Filed:

Oct 24, 2007

Appl. No.:

11/977696

Inventors:

David W. Krempin - Temecula CA, US
Mary A. Murray - Irvine CA, US
Yumei Lin - Long Beach CA, US
Kevin W. Gellenbeck - Poway CA, US
Silvia R. da Costa - Redondo Beach CA, US
Leon M. Wilkins - North Andover MA, US
Jatinder Rana - Grand Rapids MI, US
John F. Rebhun - Greenville MI, US
David J. Fast - Grand Rapids MI, US
Laurie Krempin - Temecula CA, US

International Classification:

A61K 36/254
A61K 36/48
A61K 36/87
A61P 19/00

US Classification:

424728, 424757, 424766

Abstract:

Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, sp., sp. root, Siberian ginseng, , licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, , green tea, sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

US Patent:

20080199546, Aug 21, 2008

Filed:

Oct 24, 2007

Appl. No.:

11/977395

Inventors:

David W. Krempin - Temecula CA, US
Mary A. Murray - Irvine CA, US
Yumei Lin - Long Beach CA, US
Kevin W. Gellenbeck - Poway CA, US
Silvia R. da Costa - Redondo Beach CA, US
Leon M. Wilkins - North Andover MA, US
Jatinder Rana - Grand Rapids MI, US
John F. Rebhun - Greenville MI, US
David J. Fast - Grand Rapids MI, US
Laurie Krempin - Temecula CA, US

International Classification:

A61K 36/82
C12N 5/02
A61K 36/87
A61K 36/00
A61K 31/352

US Classification:

424729, 435375, 514456, 424766, 424725

Abstract:

Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth and, decreasing or preventing bone resorption comprising a first composition comprising a combination of at least two of: quercetin, sp., sp. root, Siberian ginseng, , licorice, and ipriflavone, wherein the combination of the first composition increases BMP-2 gene expression, promoter activity, or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, , green tea, sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

US Patent:

20090170105, Jul 2, 2009

Filed:

Nov 10, 2008

Appl. No.:

12/268233

Inventors:

Kenneth S. Kornman - Newton MA, US
Leon Wilkins - North Andover MA, US

Assignee:

INTERLEUKIN GENETICS, INC. - Waltham MA

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention provides methods for the early prediction of aging-related dermatologic conditions of including skin changes associated with intrinsic aging or skin damages caused by extrinsic aging such as photoaging. The present invention also provides kits for the early determination of the propensity to develop such disorder and conditions. The method consists of detecting the presence of one or more alleles of an IL-1 haplotype or pattern, specifically the IL-1RN (+2018) and the IL-1B (−511) loci. The presence of allele 2 at the IL-1RN (+2018) and the IL-1B (−511) loci indicates decreased risk for a early onset of aging related dermatologic conditions.