Du Pont Merck Pharmaceutical Company - Wilmington DE
International Classification:
A61K 3144
US Classification:
514279
Abstract:
The invention relates to a method of treating psychosis in a mammal which comprises administering to the mammal an effective amount of a dopamine receptor antagonist antipsychotic and a sigma receptor antagonist having greater affinity for sigma receptors than for dopamine receptors, in an amount effective to selectively enhance the antipsychotic effects of the dopamine receptor antagonist relative to the adverse side effects of the dopamine receptor antagonist.
4-Aryl-4-Piperidine (Or Pyrrolidine Or Hexahydroazepine) Carbinols And Heterocyclic Analogs Thereof
Engelbert Ciganek - Kennett Square PA Leonard Cook - Newark DE
Assignee:
Du Pont Merck Pharmaceutical Company - Wilmington DE
International Classification:
A61K 31445 A61K 3144 A61K 3147
US Classification:
514326
Abstract:
Known and novel 4-aryl-4-piperidinecarbinols and heterocyclic analogs are useful as analgesics. Also provided are novel pyrrolidinecarbinols and hexahydroazepine carbinols which are useful as analgesics, antidepressants and, in some cases, as anorectic agents.
Use Of Sigma Receptor Antagonists For Treatment Of Cocaine Abuse
Du Pont Merck Pharmaceutical Company - Wilmington DE
International Classification:
A61K 31445 A61K 31505 A61K 3144 A61K 3121
US Classification:
514317
Abstract:
The invention relates to a method of treating cocaine abuse or addiction in a mammal which comprises administering to the mammal an effective amount of a sigma receptor antagonist lacking or having relatively weak dopamine receptor-blocking activity, to reduce the pharmacological effects of the cocaine.
Use Of Sigma Receptor Antagonists For Treatment Of Amphetamine Abuse
Du Pont Merck Pharmaceutical Company - Wilmington DE
International Classification:
A61K 31445 A61K 31505 A61K 3144 A61K 3140
US Classification:
514317
Abstract:
The invention relates to a method of treating drug abuse or addiction involving amphetamine or amphetamine-related drugs with pharmacological effects similar to amphetamine in a mammal which comprises administering to the mammal an effective amount, to reduce the pharmacological effects of the amphetamine or amphetamine-related drug, of certain piperidine sigma receptor antagonists.
4-Aryl-4-Piperidine (Or Pyrrolidine Or Hexahydroazepine) Carbinols And Heterocyclic Analogs Thereof
Engelbert Ciganek - Kennett Square PA Leonard Cook - Newark DE
Assignee:
E. I. Du Pont de Nemours and Company - Wilmington DE
International Classification:
C07D22307
US Classification:
540609
Abstract:
Known and novel 4-aryl-4-piperidinecarbinols and heterocyclic analogs are useful as analgesics. Also provided are novel pyrrolidinecarbinols and hexhydroazepine carbinols which are useful as analgesics, antidepressants and, in some cases, as anorectic agents.
Combination Of An Opioid Antagonist And A Selective Serotonin Reuptake Inhibitor For Treatment Of Alcoholism And Alcohol Dependence
The invention relates to a method of treating alcoholism and alcohol dependence in a mammal comprising administering to the mammal a therapeutically effective amount of a synergistic combination of: (i) at least one opioid antagonist, and (ii) at least one selective serotonin reuptake inhibitor. The invention also relates to compositions and kits containing the same.
Combination Of An Opioid Antagonist And A Selective Serotonin Reuptake Inhibitor For Treatment Of Alcoholism And Alcohol Dependence
The invention relates to a method of treating alcoholism and alcohol dependence in a mammal comprising administering to the mammal a therapeutically effective amount of a synergistic combination of: (i) at least one opioid antagonist, and (ii) at least one selective serotonin reuptake inhibitor. The invention also relates to compositions and kits containing the same.
May 15, 2009 ... Arthur Leonard Cook (born April 20, 1912, date of death unknown) was an Australian boxer who competed in the 1936 Summer Olympics. ...
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