Leonard N Lothstein

US Patent:

20060199775, Sep 7, 2006

Filed:

Mar 6, 2006

Appl. No.:

11/369225

Inventors:

Leonard Lothstein - Eads TN, US
Mervyn Israel - Germantown TN, US
Trevor Sweatman - Memphis TN, US
Polly Hofmann - Memphis TN, US

International Classification:

A61K 31/704

US Classification:

514034000

Abstract:

Compounds for the inducing apoptosis in cancer cells are described. The described compounds induce the translocation of protein kinase C-δ to the mitochondria and the phosphorylation of mitochondrial phospholipid scramblase 3. The compounds also provide cardioprotection through the translocation and activation of protein kinase C-ε in cardiomyocytes, thereby inhibiting apoptosis in carciomyocytes.

US Patent:

20150071989, Mar 12, 2015

Filed:

Sep 5, 2014

Appl. No.:

14/478643

Inventors:

- Knoxville TN, US
George C. Wood - Bartlett TN, US
Leonard Lothstein - Eads TN, US
Pavan Balabathula - Memphis TN, US
Bivash Mandal - Memphis TN, US

International Classification:

A61K 39/44
A61K 31/704
A61K 9/127

US Classification:

424450, 4241331, 4241431

Abstract:

Targeted liposomes containing chemotherapeutic compounds of Formula (I) are provided for treating hematological cancers. The targeted liposomes can be targeted to cancer cells (e.g., malignant B cells) by attachment to an antibody or antibody fragment of a suitable cell surface antigen, e.g., CD22. The targeted liposomes have higher ICs for cells not having the cell surface antigen as compared to similar non-targeted liposomes. Also provided are methods of preparing the targeted liposomes.