Leonid E Lerner

US Patent:

7200432, Apr 3, 2007

Filed:

Mar 21, 2003

Appl. No.:

10/393254

Inventors:

Eduard N. Lerner - Amsterdam, NL
Leonid Lerner - Los Angeles CA, US

Assignee:

Intrabrain International NV - Curacao

International Classification:

A61N 1/30
A61M 31/00

US Classification:

604 20, 604 21, 604501

Abstract:

A device and methods are described for a non-invasive transnasal and transocular drug delivery to the central nervous system using iontophoresis technology. By delivered through the olfactory nerve and the optical nerve, a biologically active substance of interest can be enhanced to be delivered into the CNS and CSF and bypassing the blood-brain barrier. Such drug delivery system can also be enhanced by using phonophoresis and other enhancement techniques.

US Patent:

20020123678, Sep 5, 2002

Filed:

May 20, 1998

Appl. No.:

09/077123

Inventors:

EDUARD N. LERNER - AMSTERDAM, NL
LEONID LERNER - LOS ANGELES CA, US

International Classification:

A61B005/04
A61B017/20

US Classification:

600/378000, 604/022000, 600/554000

Abstract:

A device to enhance the delivery of a drug or other substance of interest into a selected organ or tissue, comprising special electrodes, one of the electrodes carrying a container with the selected drug or other substance of interest, said electrodes being capable of being positioned at preselected locations of said organ or tissue, wherein the electrodes are all connected with a selected energy source which generates and maintains an energy field before and during the enhanced delivery of said substance, under the influence of which delivery is accomplished in a direction from the active to the passive electrode and into said organ or tissue. The energy source may be selected from suitable sources providing an electric field, a magnetic field, ultrasonic waves, high energy waves like laser beams, or a combination thereof. Further a method for the enhanced delivery of said drug or other substance of interest to an internal organ or target tissue of an organism, for example the brain, bypassing the blood-brain barrier, is disclosed.

US Patent:

20120078224, Mar 29, 2012

Filed:

Mar 31, 2011

Appl. No.:

13/077929

Inventors:

Leonid E. Lerner - Corona Del Mar CA, US
Igor Shubayev - San Diego CA, US

Assignee:

OcuJect, LLC - Corona Del Mar CA

International Classification:

A61F 9/00
A61M 5/315

US Classification:

604506, 604187, 604208, 604218

Abstract:

Devices for delivering pharmaceutical formulations into the eye are described. The devices may be integrated to include features that allow safe and atraumatic manipulation of the devices with one hand. For example, accurate placement, including proper angulation, of the device on the eye and injection of a pharmaceutical formulation into the eye can be performed using one hand. The devices may also include improved safety features. For example, the devices may include an actuation mechanism that controls the rate and depth of injection into the eye. Some devices include a dynamic resistance component capable of adjusting the amount of pressure applied to the eye surface. Related methods and systems comprising the devices are also described.

US Patent:

20130296825, Nov 7, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/841144

Inventors:

Leonid E. LERNER - Corona Del Mar CA, US

International Classification:

A61M 5/46

US Classification:

604506, 604117

Abstract:

Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on a removable injector attachment or on a portion of the injection device housing. Other devices may include a filter for the removal of air, infectious agents, and/or other particulate matter from the composition before the composition is injected into the eye. Related methods and systems comprising the devices are also described.

US Patent:

20140039456, Feb 6, 2014

Filed:

Oct 7, 2013

Appl. No.:

14/047476

Inventors:

Leonid E. LERNER - Corona Del Mar CA, US

International Classification:

A61M 5/42

US Classification:

604506, 604116

Abstract:

Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on the injector device, or on a portion of the injection device housing, or on a drug reservoir. Some devices may be removably attached to a drug reservoir, for example, through a luer connector. Other devices may comprise internal luer seal for securely connecting a drug conduit of the device to the luer cavity of a drug reservoir. Yet other devices may comprise a priming-enabling element to facilitate the drug priming of a shielded needle. Related methods and systems comprising the devices are also described.

US Patent:

20230078528, Mar 16, 2023

Filed:

Nov 23, 2022

Appl. No.:

17/993309

Inventors:

- Newport Beach CA, US
Leonid E. Lerner - Corona Del Mar CA, US

International Classification:

A61F 9/00
A61M 5/42
A61M 5/32
A61M 5/31
A61M 5/38
A61M 5/46
A61F 9/007

Abstract:

Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on the injector device, or on a portion of the injection device housing, or on a drug reservoir. Some devices may be removably attached to a drug reservoir, for example, through a luer connector. Other devices may comprise internal luer seal for securely connecting a drug conduit of the device to the luer cavity of a drug reservoir. Yet other devices may comprise a priming-enabling element to facilitate the drug priming of a shielded needle. Related methods and systems comprising the devices are also described.

US Patent:

20200214889, Jul 9, 2020

Filed:

Jan 6, 2020

Appl. No.:

16/735361

Inventors:

- Newport Beach CA, US
Leonid E. Lerner - Corona Del Mar CA, US

International Classification:

A61F 9/007
A61F 9/00
A61M 5/46
A61M 5/38
A61M 5/31
A61M 5/32

Abstract:

Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on a removable injector attachment or on a portion of the injection device housing. Other devices may include a filter for the removal of air, infectious agents, and/or other particulate matter from the composition before the composition of air, infectious agents, and/or other particulate matter from the composition before the composition is injected into the eye. Related methods and systems comprising the devices are also described.

US Patent:

20200000635, Jan 2, 2020

Filed:

Apr 8, 2019

Appl. No.:

16/378347

Inventors:

- Newport Beach CA, US
Leonid E. Lerner - Corona Del Mar CA, US

International Classification:

A61F 9/00
A61F 9/007
A61M 5/32
A61M 5/20
A61M 5/42
A61M 5/46

Abstract:

Injection devices for delivering pharmaceutical formulations into the eye are described. The devices may be integrated to include features that allow safe and atraumatic manipulation of the devices with one hand. For example, accurate placement, including proper angulation, of the device on the eye and injection of a pharmaceutical formulation into the eye can be performed using one hand. The devices may also include improved safety features. For example, the devices may include an actuation mechanism that controls the rate and depth of injection into the eye. Some devices include a dynamic resistance component capable of adjusting the amount of pressure applied to the eye surface. Related methods and systems comprising the devices are also described.