Leroy J Young

US Patent:

20120238937, Sep 20, 2012

Filed:

Feb 2, 2012

Appl. No.:

13/364547

Inventors:

Nicholas M. Dean - Encinitas CA, US
Lincoln Krochmal - Los Gatos CA, US
Gregory Hardee - Del Mar CA, US
J. Gordon Foulkes - Encinitas CA, US
Niall O'Donnell - Encinitas CA, US
Leroy Young - Wildwood MO, US
Mark Jewell - Eugene OR, US

International Classification:

A61K 31/7088
A61K 31/713
A61K 31/7105
A61K 31/711
A61M 5/00
A61K 31/712
A61K 31/7115
A61M 37/00
A61N 1/30
A61P 17/02
A61K 31/7125

US Classification:

604 20, 514 44 A, 604 22, 604506

Abstract:

This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.

US Patent:

20200190521, Jun 18, 2020

Filed:

Sep 20, 2019

Appl. No.:

16/136750

Inventors:

Nicholas M. Dean - Encinitas CA, US
Lincoln Krochmal - Los Gatos CA, US
Gregory Hardee - Del Mar CA, US
J. Gordon Foulkes - Encinitas CA, US
Niall O'Donnell - St. Louis MO, US
Leroy Young - Wildwood MO, US
Mark Jewell - Eugene OR, US

Assignee:

Excaliard Pharmaceuticals, Inc. - New York NY

International Classification:

C12N 15/113
A61K 45/06
A61K 31/712
A61K 31/7088

Abstract:

This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.