Leslie H Anderson

US Patent:

52625249, Nov 16, 1993

Filed:

Nov 15, 1991

Appl. No.:

7/793051

Inventors:

Leslie D. Anderson - Encinitas CA
Clarence N. Ahlem - San Diego CA
Ann E. Huang - Carlsbad CA

Assignee:

Hybritech Incorporated - San Diego CA

International Classification:

A61K 3514
A61K 3900
C07K 300
C12Q 100

US Classification:

5303911

Abstract:

The present invention is directed to a method for extending the length of one of the three linker arms of the compound of Formula I in the production of novel trifunctional antibody-like compounds. Formula I is defined as follows: ##STR1## wherein X is ##STR2## wherein k=1 or 0; wherein Z is ##STR3## wherein s=1 or 0; wherein n=1 or 0; wherein q=1 or 0; wherein Y is ##STR4## wherein Y' is ##STR5## wherein p or m may be the same or different and are integers ranging from 0 to 20 with the provisos that when n=0, the sum of m and p is an integer ranging from 1 to 20, whereas when n=1, p and m are each an integer that is at least 1 and the sum of p and m is an integer ranging from 2 to 20; wherein R. sup. 1 is straight or branched chain lower alkyl having from 1 to 6 carbon atoms or lower alkoxy having from 1-6 carbon atoms; and wherein R. sup. 2 is hydrogen, phenyl, --COOH, or straight or branched chain lower alkyl having from 1-6 carbon atoms, with the proviso that the lower alkyl moiety may be mono substituted by --NH. sub.

US Patent:

53851471, Jan 31, 1995

Filed:

Sep 22, 1993

Appl. No.:

8/125621

Inventors:

Leslie D. Anderson - Encinitas CA
Janeth M. Bartlett - San Diego CA
Diane M. Szaflarski - San Diego CA
Kenneth J. Widder - Rancho Santa Fe CA

Assignee:

Molecular Biosystems, Inc. - San Diego CA

International Classification:

A61B 800

US Classification:

12866202

Abstract:

A method for enhanced ultrasonic imaging of the tissues defining the gastrointestinal tract and the upper abdominal organs wherein the gastrointestinal tract is filled with a chemically defined essentially sonolucent ultrasound contrast agent that is stable under gastric conditions and has a gastric emptying time of at least about twenty minutes, thus causing the lumen of the upper gastrointestinal tract to appear dark relative to the positive image of the gastrointestinal tract walls and upper abdominal organs.

US Patent:

54398290, Aug 8, 1995

Filed:

Jan 24, 1992

Appl. No.:

7/826928

Inventors:

Leslie D. Anderson - Encinitas CA
James A. Cook - Indianapolis IN
Gary S. David - La Jolla CA
Susan M. Hochschwender - Del Mar CA
Mary S. Kasher - Indianapolis IN
Michele C. Smith - Indianapolis IN
Willem P. C. Stemmer - Carlsbad CA

Assignee:

Eli Lilly and Company - Indianapolis IN
Hybritech Incorporated - San Diego CA

International Classification:

G01N 33543
G01N 33549
C12N 1100
C07K 1700

US Classification:

436518

Abstract:

A chelating agent is covalently bonded to a biologically active molecule such as an enzyme or antibody, the biologically active molecule is contacted with a support containing a bound transition metal ion whereby the metal ion is chelated by the chelating agent and the oxidation state of the metal ion is changed by treatment with an oxidizing or a reducing agent to provide a kinetically inert: oxidation state to immobilize the biologically active molecule on the support. The transition metal ion is preferably Co(II), Cr(II) or Ru(III) and the oxidation state of the metal ion is changed to Co(III), Cr(III) or Ru(II), respectively. The chelating agent can be iminodiacetic acid, nitrilotriacetic acid, terpyridine, bipyridine, triethylenetetraamine, biethylenetriamine, 1,4,7-triazacyclonane or a chelating peptide. Certain chelating agents can immobilize more than one biologically active molecule at a metal ion site on the support. The immobilized biologically active molecules can be used in affinity chromatography or in assay systems.

US Patent:

60454288, Apr 4, 2000

Filed:

Feb 25, 1999

Appl. No.:

9/258245

Inventors:

Leslie L. Anderson - San Diego CA
Vitale M. Sgambelluri - San Diego CA
Andree J. Pyfer - Encinitas CA

Assignee:

Sony Corporation of Japan - Tokyo
Sony Electronics, Inc. - Park Ridge NJ

International Classification:

H01J 902

US Classification:

445 60

Abstract:

A method and apparatus for cleaning an electron gun of a CRT wherein said method and apparatus prevents damage to the CRT's during the cleaning process. A protective cap is placed over the pins of an assembled CRT for protecting the pins against damage. The CRT is then lowered into a container that is filled with dielectric-fluid. A socket that includes a central opening is disposed in the container. The pins of the CRT are electrically coupled to the socket. The dielectric-fluid is circulated through the central opening of the socket so as to remove any air trapped between the stem base surface of the CRT and the protective cap. A high voltage electrical current is then selectively applied to the pins for cleaning the electron gun of the CRT.