Lewis A Marshall

US Patent:

20190078077, Mar 14, 2019

Filed:

Nov 15, 2018

Appl. No.:

16/192034

Inventors:

- Stanford CA, US
Lewis A. Marshall - Pleasanton CA, US
Anita Rogacs - Los Altos CA, US

International Classification:

C12N 15/10
B01L 3/00
B01D 57/02
C12Q 1/6806
G01N 27/447

Abstract:

Various aspects of the present disclosure are directed toward methods and apparatuses for interacting a first liquid and a second liquid in one or more fluidic channels of a capillary structure. The methods and apparatuses can include providing at least one capillary barrier that positions a meniscus of the first liquid at a fluid-interface region using capillary forces within the capillary structure. Additionally, a path is provided along one of the channels for the second liquid to flow toward the fluid-interface region. Additionally, gas pressure is released, via a gas-outflow port, from the fluid-interface region while flow of the first liquid is arrested. Further, the first liquid and the second liquid contact in the fluid-interface region with the capillary barrier holding the first liquid at the fluid-interface region.

US Patent:

20180237767, Aug 23, 2018

Filed:

Dec 22, 2017

Appl. No.:

15/853370

Inventors:

- Stanford CA, US
Lewis A. Marshall - Pleasanton CA, US
Anita Rogacs - Los Altos CA, US

International Classification:

C12N 15/10
C12Q 1/6806
B01L 3/00
B01D 57/02
G01N 27/447

Abstract:

Various aspects of the present disclosure are directed toward methods and apparatuses for interacting a first liquid and a second liquid in one or more fluidic channels of a capillary structure. The methods and apparatuses can include providing at least one capillary barrier that positions a meniscus of the first liquid at a fluid-interface region using capillary forces within the capillary structure. Additionally, a path is provided along one of the channels for the second liquid to flow toward the fluid-interface region. Additionally, gas pressure is released, via a gas-outflow port, from the fluid-interface region while flow of the first liquid is arrested. Further, the first liquid and the second liquid contact in the fluid-interface region with the capillary barrier holding the first liquid at the fluid-interface region.

US Patent:

20160169801, Jun 16, 2016

Filed:

May 9, 2014

Appl. No.:

14/891310

Inventors:

- Palo Alto CA, US
Lewis A. Marshall - Pleasanton CA, US
Juan G. Santiago - Stanford CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

G01N 21/64
G01N 33/58
G01N 33/53
G06T 7/20
C12Q 1/68

Abstract:

Techniques for characterizing targets include obtaining multiple time series of images. Each image represents light measured in an interrogation area under conditions that cause only one optical marker type of at least two optical marker types to emit or scatter light. Each different time series indicates light measured from a different single optical marker type. The at least two optical marker types are configured to collocate with a single target type. The techniques include determining a path of a speck of light from an individual optical marker of a first optical marker type. The techniques also include determining whether the path corresponds to the target type based on persistence of collocation of a speck of light from each of the other optical marker types. The collocation can be based on maximum correlation in a portion of contemporaneous images. The persistence can be long compared to random separation times.

US Patent:

20160160208, Jun 9, 2016

Filed:

Mar 14, 2014

Appl. No.:

14/213832

Inventors:

- Palo Alto CA, US
Lewis A. Marshall - Pleasanton CA, US
Anita Rogacs - Los Altos CA, US

International Classification:

C12N 15/10
C12Q 1/68
B01D 57/02
B01L 3/00

Abstract:

Various aspects of the present disclosure are directed toward methods and apparatuses for interacting a first liquid and a second liquid in one or more fluidic channels of a capillary structure. The methods and apparatuses can include providing at least one capillary barrier that positions a meniscus of the first liquid at a fluid-interface region using capillary forces within the capillary structure. Additionally, a path is provided along one of the channels for the second liquid to flow toward the fluid-interface region. Additionally, gas pressure is released, via a gas-outflow port, from the fluid-interface region while flow of the first liquid is arrested. Further, the first liquid and the second liquid contact in the fluid-interface region with the capillary barrier holding the first liquid at the fluid-interface region.