Li Ju Huang

Address:

2217 W Taylor St APT 1F, Chicago, IL 60612

Phone:

6309157906

VIN:

WBAXH5C50CDW02127

Make:

BMW

Model:

5-SERIES

Year:

2012

US Patent:

7026305, Apr 11, 2006

Filed:

Apr 14, 2003

Appl. No.:

10/413193

Inventors:

Chin Ho Chen - Chapel Hill NC, US
Li Huang - Chapel Hill NC, US

Assignee:

Meharry Medical College - Nashville TN

International Classification:

A61K 31/565
C07J 53/00

US Classification:

514169, 552510

Abstract:

The present invention provides compounds of the general structure: which are substituted at the 3 and 28 positions, along with pharmaceutical formulations containing the same and methods of treating viral infections employing the same.

US Patent:

7381717, Jun 3, 2008

Filed:

Feb 6, 2006

Appl. No.:

11/348052

Inventors:

Chin Ho Chen - Chapel Hill NC, US
Li Huang - Chapel Hill NC, US

Assignee:

Meharry Medical College - Nashville TN

International Classification:

A61K 31/56
C07J 53/00

US Classification:

514169, 552510

Abstract:

The present invention provides compounds of the general structure:.

US Patent:

20110152229, Jun 23, 2011

Filed:

Nov 21, 2007

Appl. No.:

11/943956

Inventors:

Chin Ho Chen - Chapel Hill NC, US
Li Huang - Chapel Hill NC, US
Kuo-Hsiung Lee - Chapel Hill NC, US

International Classification:

A61K 31/56
C07J 53/00
A61P 31/18

US Classification:

514182, 552510

Abstract:

The present invention provides compounds of the general structure:which are substituted at the 3 and 28 positions, along with pharmaceutical formulations containing the same and methods of treating viral infections employing the same.

US Patent:

20120101098, Apr 26, 2012

Filed:

May 10, 2010

Appl. No.:

13/320642

Inventors:

Kuo-Hsiung Lee - Chapel Hill NC, US
Keduo Qian - Carrboro NC, US
Donglei Yu - Bethesda MD, US
Chin-Ho Chen - Chapel Hill NC, US
Li Huang - Chapel Hill NC, US
Ibrahim Danlami Bori - Durham NC, US

International Classification:

A61K 31/5377
C07D 211/34
C07D 413/06
C07D 413/12
A61P 31/18
A61K 31/194
A61K 31/445
A61K 31/215
A61K 31/25
A61P 31/14
C07C 235/82
C07C 69/753

US Classification:

5142355, 562403, 546195, 544130, 560 6, 514563, 514319, 5142372, 514510

Abstract:

Compounds according to Formula (I) are described along with compositions containing the same and methods of use thereof for the treatment of viral infections.

US Patent:

57262047, Mar 10, 1998

Filed:

Jun 5, 1995

Appl. No.:

8/462280

Inventors:

Kuo-Hsiung Lee - Chapel Hill NC
Yoshiki Kashiwada - Chapel Hill NC
Li Huang - Chapel Hill NC
Thomas Tung-Ying Lee - Chapel Hill NC
Mark Cosentino - Springfield VA
Jim Snider - Hagerstown MD
Mark Manak - Laurel MD
Lan Xie - Chapel Hill NC

Assignee:

Biotech Research Laboratories - Rockville MD
University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

A61K 31365
C07D31194
C07D49306

US Classification:

514455

Abstract:

The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula I: ##STR1## wherein R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 4, R. sup. 5 and R. sup. 6 are defined herein. The invention is also directed to methods of making these compounds, pharmaceutical compositions including these compounds and methods of using the compounds to inhibit retroviral infections in cells and tissues of animals. A method for stereoselectively preparing compounds within the scope of the invention by catalytic asymmetric dihydroxylation is also disclosed.

US Patent:

63199297, Nov 20, 2001

Filed:

Dec 8, 1998

Appl. No.:

9/207500

Inventors:

Kuo-Hsiung Lee - Chapel Hill NC
Yoshiki Kashiwada - Kurosaki-machi, JP
Li Huang - Franklin TN
Thomas Tung-Ying Lee - Chapel Hill NC
Mark Cosentino - Springfield VA
Jim Snider - Pleasanton CA
Mark Manak - Laurel MD
Lan Xie - Chapel Hill NC

Assignee:

The University of North Carolina at Chapel Hill - Chapel Hill
Panacos Pharmaceuticals, Inc. - Gaithersburg MD

International Classification:

A61K 31436
A61K 31352
A61K 31366
C07D49102
C07D31178

US Classification:

514291

Abstract:

The present invention is directed to compounds that are analogs of the natural product suksdorfin. Compounds of the present invention include those having Formula IV: ##STR1## wherein R. sup. 20 through R. sup. 26, M and Z are defined herein. The invention is also directed to pharmaceutical compositions and methods of using these compositions for treating retroviral infections.

US Patent:

56375891, Jun 10, 1997

Filed:

Feb 21, 1995

Appl. No.:

8/392558

Inventors:

Kuo-Hsiung Lee - Chapel Hill NC
Yoshiki Kashiwada - Chapel Hill NC
Li Huang - Chapel Hill NC
Thomas T. Lee - Chapel Hill NC
Mark Cosentino - Springfield VA
Jim Snider - Hagerstown MD
Mark Manax - Laurel MD
Lan Xie - Chapel Hill NC

Assignee:

University of North Carolina at Chapel Hill - Chapel Hill NC
Biotech Research Laboratories - Rockville MD

International Classification:

A61K 31435
C07D491052

US Classification:

514291

Abstract:

Compounds, including compositions and methods of making and using these compounds for treating retroviral infections, are provided according to formula (G-1): ##STR1## wherein M is O or NH; Z is O, NH or S; R. sup. 240, and R. sup. 250 are each H, C. sub. 1-10 alkyl, C. sub. 1-10 aryl, alkyl, amide, or CH. sub. 2 COOR. sup. 260, where R. sup. 260 is C. sub. 1-10 alkyl or acyl; R. sup. 200, R. sup. 210, R. sup. 220 and R. sup. 230 are each H, halogen, hydroxyl, NH. sub. 2, NH-alkyl, N-(alkyl). sub. 2, O-alkyl, O-acyl, COCF. sub. 3, OCF. sub. 3 or CH. sub. 2 COO NH-alkyl; or R. sup. 200 and R. sup. 210 form C. sub. 5 -C. sub. 10 cyclo or heterocyclo optionally substituted with one or more of halogen, hydroxyl, NH. sub. 2, NH-alkyl, N-(alkyl). sup. 2, O-acyl, O-alkyl, CO, CF. sub. 3, OCF. sub. 3 or CH. sub.