Li L Tang

US Patent:

6448446, Sep 10, 2002

Filed:

Jan 12, 2001

Appl. No.:

09/760202

Inventors:

Li Tang - San Diego CA
Yuying Tan - San Diego CA

Assignee:

AntiCancer, Inc. - San Diego CA

International Classification:

C07C20900

US Classification:

564437, 564416, 564419, 564438, 564394

Abstract:

An improved synthesis of N,N,-disubstituted-p-phenylene-diamine (DSPDA) preferably di-n-butyl-p-phenylenediamine is disclosed. The improvement rests on the discovery that DSPDA and its salts are extremely sensitive to oxygen so that once the product DSPDA or its salt is formed, oxygen must be excluded from all manipulations.

US Patent:

6653092, Nov 25, 2003

Filed:

Oct 30, 2001

Appl. No.:

10/003597

Inventors:

Qinghong Han - San Diego CA
Li Tang - San Diego CA
Mingxu Xu - San Diego CA
Yuying Tan - San Diego CA
Shigeo Yagi - San Diego CA

Assignee:

AntiCancer, Inc. - San Diego CA

International Classification:

C12Q 148

US Classification:

435 15, 435 4, 564305

Abstract:

A method to detect and measure the concentration of hydrogen peroxide comprises adding reagents consisting essentially of peroxidase and a dialkyl phenylenediamine and detecting any color generated by the interaction of hydrogen peroxide with these reagents.

US Patent:

6927038, Aug 9, 2005

Filed:

Nov 20, 2002

Appl. No.:

10/301531

Inventors:

Qinghong Han - San Diego CA, US
Mingxu Xu - La Jolla CA, US
Li Tang - San Diego CA, US
Yuying Tan - San Diego CA, US

Assignee:

AntiCancer, Inc. - San Diego CA

International Classification:

C12Q001/34
C12Q003/00
G01N033/53

US Classification:

435 18, 435 4, 435975

Abstract:

A method to determine a total cysteine in biological fluids utilizes similarly treated portions of the fluid with a homocysteinase and a non-specific desulfurase.

US Patent:

63291622, Dec 11, 2001

Filed:

Apr 17, 2000

Appl. No.:

9/550723

Inventors:

Qinghong Han - San Diego CA
Li Tang - San Diego CA
Mingxu Xu - San Diego CA
Yuying Tan - San Diego CA
Shigeo Yagi - San Diego CA

Assignee:

AntiCancer, Inc. - San Diego CA

International Classification:

C12Q 148
C12Q 100

US Classification:

435 15

Abstract:

A method to assess the level of folate in a biological sample comprises: providing said sample with glycine N-methyltransferase (GMT) and with an excess of S-adenosyl methionine (SAM) and of glycine; providing a control which contains no folate with said GMT and excess SAM and glycine in comparable amounts to those provided to the sample; and comparing the concentration of at least one product formed in the sample with the concentrations of said product formed in the control, whereby the difference in levels of said product in the sample as compared to the control is directly proportional to the level of folate in the sample.

US Patent:

60664673, May 23, 2000

Filed:

Jun 28, 1999

Appl. No.:

9/340991

Inventors:

Mingxu Xu - San Diego CA
Yuying Tan - San Diego CA
Qinghong Han - San Diego CA
Li Tang - San Diego CA

Assignee:

AntiCancer, Inc. - San Diego CA

International Classification:

C12Q 137
C12Q 100

US Classification:

435 23

Abstract:

Novel enzymatic methods to determine the concentration of homocysteine in biological fluids are described. In a typical embodiment of the invention, the biological fluid sample is from a patient, and the methods of the invention are useful to assess risk for cardiovascular disease. The novel methods of the invention involve use of particular homocysteinase enzymes that permit the determination of homocysteine concentrations in biological samples without interference from the concentrations of cysteine and/or of methionine that are routinely present in such samples. There is also provided a diagnostic kit for use in determining the amount of homocysteine in a biological sample comprising (a) a homocysteinase having the aforementioned characteristics, and (b) at least one reagent capable of being used to determine the amount of product formed in the homocysteinase reaction. In a further aspect, the homocysteinase is provided as a chimeric molecule that comprises amino acid subsequences derived from, or patterned on, more than one homocysteinase, and which is typically produced from a chimeric polynucleotide that encodes therefor. Additional enhancements in homocysteine assay methodology include use of the enzyme. gamma.

US Patent:

20220185860, Jun 16, 2022

Filed:

Feb 28, 2022

Appl. No.:

17/682633

Inventors:

- Cambridge MA, US
Yiran ZHENG - Cambridge MA, US
Li TANG - Quincy MA, US

International Classification:

C07K 14/55
C07K 14/705
C07K 14/54
A61K 9/127
C07K 16/28
C07K 14/715
A61K 47/68
A61K 47/69
A61K 47/60
A61K 39/00
C07K 14/725
C07K 16/30
C07K 19/00

Abstract:

The present disclosure is directed, in some embodiments, to methods and compositions of comprising a cell having a non-internalizing receptor, and a nanoparticle surface-modified with a ligand that binds to the non-internalizing receptor.

US Patent:

20210269500, Sep 2, 2021

Filed:

May 12, 2021

Appl. No.:

17/318590

Inventors:

- Cambridge MA, US
Yiran ZHENG - Cambridge MA, US
Li TANG - Quincy MA, US

International Classification:

C07K 14/725
C07K 16/28
C07K 14/705
C07K 14/715
C07K 19/00
A61K 47/60
A61K 47/69
C07K 14/54
C07K 16/30
A61K 39/00
C07K 14/55
A61K 47/68
A61K 9/127
C12N 5/00
C12N 5/0783
A61P 35/00

Abstract:

The present disclosure is directed, in some embodiments, to methods and compositions of comprising a cell having a non-internalizing receptor, and a nanoparticle surface-modified with a ligand that binds to the non-internalizing receptor.

US Patent:

20170080104, Mar 23, 2017

Filed:

Aug 12, 2016

Appl. No.:

15/236186

Inventors:

- Cambridge MA, US
Yiran ZHENG - Cambridge MA, US
Li Tang - Quincy MA, US

International Classification:

A61K 9/127
A61K 39/00
C07K 14/55
C07K 16/30
C07K 14/705
C07K 14/725
C12N 5/0783
C07K 19/00

Abstract:

The present disclosure is directed, in some embodiments, to methods and compositions of comprising a cell having a non-internalizing receptor, and a nanoparticle surface-modified with a ligand that binds to the non-internalizing receptor.